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Dexmedetomidine expands monocytic myeloid-derived suppressor cells and promotes tumour metastasis after lung cancer surgery

Dexmedetomidine (DEX) has been reported to promote tumour metastases. However the underlying mechanisms remain unclear. The purpose of this study was to investigate whether DEX promotes tumour metastasis by inducing myeloid-derived suppressor cells (MDSC) in the context of surgery. DEX was given to lung cancer patients and its effects on expansion of monocytic MDSC (M-MDSC) were...

Bone marrow mesenchymal stem cells tune the differentiation of myeloid-derived suppressor cells in bleomycin-induced lung injury

Bone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involved in this effect. However, the mechanisms by which BMSC modulate neutrophil remains unknown. Exposure of mice to bleomycin (BLM) resulted in significant accumulation of...

Bone marrow mesenchymal stem cells tune the differentiation of myeloid-derived suppressor cells in bleomycin-induced lung injury

BackgroundBone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involved in this effect. However, the mechanisms by which BMSC modulate neutrophil remains unknown.Methods and resultsExposure of mice to bleomycin (BLM) resulted in...

Design of FPGA-Based Accelerator for Convolutional Neural Network under Heterogeneous Computing Framework with OpenCL

CPU has insufficient resources to satisfy the efficient computation of the convolution neural network (CNN), especially for embedded applications. Therefore, heterogeneous computing platforms are widely used to accelerate CNN tasks, such as GPU, FPGA, and ASIC. Among these, FPGA can accelerate the computation by mapping the algorithm to the parallel hardware instead of CPU, which...

Design of FPGA-Based Accelerator for Convolutional Neural Network under Heterogeneous Computing Framework with OpenCL

CPU has insufficient resources to satisfy the efficient computation of the convolution neural network (CNN), especially for embedded applications. Therefore, heterogeneous computing platforms are widely used to accelerate CNN tasks, such as GPU, FPGA, and ASIC. Among these, FPGA can accelerate the computation by mapping the algorithm to the parallel hardware instead of CPU, which...

De novo leaf and root transcriptome analysis to identify putative genes involved in triterpenoid saponins biosynthesis in Hedera helix L.

. Expressed higher DEGs in leaf. (XLS) S8 Table. Expressed lower DEGs in leaf. (XLS) S9 Table. Annotation_CYP450s. (XLS) S10 Table. Annotation_GTs. (XLS) Author Contributions Conceptualization: Fei Qiao ... , Xiaohong Zhong. Data curation: Huapeng Sun, Fang Li, Xiaohong Zhong. Formal analysis: Huapeng Sun, Zijian Xu, Mengli Sun, Hanqing Cong, Fei Qiao, Xiaohong Zhong. Funding acquisition: Fei Qiao, Xiaohong

De Novo Characterization of a Cephalotaxus hainanensis Transcriptome and Genes Related to Paclitaxel Biosynthesis

Cephalotaxus hainanensis, an endangered plant, is known to contain several metabolites with anti-cancer activity. Despite its clinical impact, the alkaloid metabolism of this species has remained largely uncharacterized. The potential of Cephalotaxus for metabolic engineering of medically interesting compounds has, so far, not been exploited, due to the almost complete lack of...

The Phytoalexin Resveratrol Regulates the Initiation of Hypersensitive Cell Death in Vitis Cell

Resveratrol is a major phytoalexin produced by plants in response to various stresses and promotes disease resistance. The resistance of North American grapevine Vitis rupestris is correlated with a hypersensitive reaction (HR), while susceptible European Vitis vinifera cv. ‘Pinot Noir’ does not exhibit HR, but expresses basal defence. We have shown previously that in cell lines...

The cytoskeleton enhances gene expression in the response to the Harpin elicitor in grapevine

GdCl3 before 9 lg ml 1 Harpin were added. Acknowledgements This work was supported by fellowships of the Chinese Scholarship Council (CSC) to Fei Qiao and Xiaoli Chang. PD Dr Hanns-Heinz Kassemeyer

Light can rescue auxin-dependent synchrony of cell division in a tobacco cell line

Pattern formation in plants has to cope with ambient variability and therefore must integrate environmental cues such as light. Synchrony of cell divisions was previously observed in cell files of tobacco suspension cultures, which represents a simple case of pattern formation. To develop cellular approaches for light-dependent patterning, light-responsive tobacco cell lines were...

Angiotensin-converting enzyme insertion/deletion gene polymorphism and risk of intracranial aneurysm in a Chinese population

Objective The relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphisms and intracranial aneurysm (IA) has been studied in Caucasian and Japanese populations. The present study aimed to investigate this association in a Chinese population.

RNA-Seq Analysis of Cocos nucifera: Transcriptome Sequencing and De Novo Assembly for Subsequent Functional Genomics Approaches

Background Cocos nucifera (coconut), a member of the Arecaceae family, is an economically important woody palm grown in tropical regions. Despite its agronomic importance, previous germplasm assessment studies have relied solely on morphological and agronomical traits. Molecular biology techniques have been scarcely used in assessment of genetic resources and for improvement of...

A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor

Background Enterovirus 71 (EV71), one of the most important neurotropic EVs, has caused death and long-term neurological sequelae in hundreds of thousands of young children in the Asia-Pacific region in the past decade. The neurological diseases are attributed to infection by EV71 inducing an extensive peripheral and central nervous system (CNS) inflammatory response with...

A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor

Enterovirus 71 (EV71), one of the most important neurotropic EVs, has caused death and long-term neurological sequelae in hundreds of thousands of young children in the Asia-Pacific region in the past decade. The neurological diseases are attributed to infection by EV71 inducing an extensive peripheral and central nervous system (CNS) inflammatory response with abnormal cytokine...

Complement and the Alternative Pathway Play an Important Role in LPS/D-GalN-Induced Fulminant Hepatic Failure

) Complement Inhibition Alleviates Paraquat-Induced Acute Lung Injury . AJRCMB;doi:10.1165/rcmb.2010- 0444OC . 26. Yuxiang Huang , Fei Qiao , Carl Atkinson , VMichael Holers, Stephen Tomlinson ( 2008 ) A Novel

A new therapeutic strategy for lung tissue injury induced by influenza with CR2 targeting complement inhibitior

Background Influenza is a respiratory disease that seriously threatens human health. In fact, influenza virus itself does not make critical contribution to mortality induced by influenza, but "cytokine storm" produced by the excessive immune response triggered by the virus can result in inflammatory reaction of lung tissues and fatal lung tissue injury, and thus increase...

A novel trifunctional IgG-like bispecific antibody to inhibit HIV-1 infection and enhance lysis of HIV by targeting activation of complement

Background The complement system is not only a key component of innate immunity but also provides a first line of defense against invading pathogens, especially for viral pathogens. Human immunodeficiency virus (HIV), however, possesses several mechanisms to evade complement-mediated lysis (CoML) and exploit the complement system to enhance viral infectivity. Responsible for this...

Mapping wetland changes in China between 1978 and 2008

Four wetland maps for all China have been produced, based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978, 1990, 2000 and 2008). These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009. Based on these maps, we analyzed the 2008 wetland distribution in China and discussed wetland changes and their...