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Image Restoration Based on the Hybrid Total-Variation-Type Model

We propose a hybrid total-variation-type model for the image restoration problem based on combining advantages of the ROF model with the LLT model. Since two -norm terms in the proposed model make it difficultly solved by using some classically numerical methods directly, we first employ the alternating direction method of multipliers (ADMM) to solve a general form of the...

A new coumarin derivative, IMM-H004, attenuates okadaic acid-induced spatial memory impairment in rats

; Xiu-yun SONG and Yingying WANG performed the main experiments; Xiu-yun SONG and Peng-fei YANG analyzed the data and wrote the paper; Wei ZUO, Lian-Kun SONG and Shuai ZHANG assisted in the experiments

OpenMS-Simulator: an open-source software for theoretical tandem mass spectrum prediction

Background Tandem mass spectrometry (MS/MS) acts as a key technique for peptide identification. The MS/MS-based peptide identification approaches can be categorized into two families, namely, de novo and database search. Both of the two types of approaches can benefit from an accurate prediction of theoretical spectrum. A theoretical spectrum consists of m/z and intensity of...

Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate

Background The development of effective chemopreventive agents against cigarette smoke-induced lung cancer could be greatly facilitated by suitable laboratory animal models, such as animals treated with the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In the current study, we established a novel lung cancer model in Wistar rats treated...

EUS assisted transmural cholecystogastrostomy fistula creation as a bridge for endoscopic internal gallbladder therapy using a novel fully covered metal stent

Background Laparoscopic cholecystectomy (LC) has become the “gold standard” for treating symptomatic gallstones. Innovative methods, such as a scarless therapeutic procedure through a natural orifice are being introduced, and include transgastric or transcolonic endoscopic cholecystectomy. However, before clinical implementation, instruments still need modification, and a more...

Comprehensive annotation of microRNA expression profiles

Background MicroRNAs (miRNAs) regulate many biological processes by post-translational gene silencing. Analysis of miRNA expression profiles is a reliable method for investigating particular biological processes due to the stability of miRNA and the development of advanced sequencing methods. However, this approach is limited by the broad specificity of miRNAs, which may target...

Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE

Background Funded by the National Institutes of Health (NIH), the aim of the Model Organism ENCyclopedia of DNA Elements (modENCODE) project is to provide the biological research community with a comprehensive encyclopedia of functional genomic elements for both model organisms C. elegans (worm) and D. melanogaster (fly). With a total size of just under 10 terabytes of data...

Parent artery reconstruction for large or giant cerebral aneurysms using a Tubridge flow diverter (PARAT): study protocol for a multicenter, randomized, controlled clinical trial

Yu Zhou 0 Peng-Fei Yang 0 Yi-Bin Fang Yi Xu Bo Hong Wen-Yuan Zhao Qiang Li Rui Zhao Qing-Hai Huang Jian-Min Liu 0 Equal contributors Department of Neurosurgery, Changhai Hospital, Second Military

Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize

Background Modifications of DNA and histones in various combinations are correlated with many cellular processes. In this study, we investigated the possible relationship between histone H4 tetraacetylation, DNA methylation and histone H3 dimethylation at lysine 9 during mitosis in maize root meristems. Results Treatment with trichostatin A, which inhibits histone deacetylases...

Imprecise intron losses are less frequent than precise intron losses but are not rare in plants

In this study, we identified 19 intron losses, including 11 precise intron losses (PILs), six imprecise intron losses (IILs), one de-exonization, and one exon deletion in tomato and potato, and 17 IILs in Arabidopsis thaliana. Comparative analysis of related genomes confirmed that all of the IILs have been fixed during evolution. Consistent with previous studies, our results...

Imprecise intron losses are less frequent than precise intron losses but are not rare in plants

In this study, we identified 19 intron losses, including 11 precise intron losses (PILs), six imprecise intron losses (IILs), one de-exonization, and one exon deletion in tomato and potato, and 17 IILs in Arabidopsis thaliana. Comparative analysis of related genomes confirmed that all of the IILs have been fixed during evolution. Consistent with previous studies, our results...

Why eukaryotic cells use introns to enhance gene expression: Splicing reduces transcription-associated mutagenesis by inhibiting topoisomerase I cutting activity

-Fei Yang 0 0 Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, College of Life Sciences, Beijing Normal University , Beijing 100875 , China Background: The costs

L∞ estimates of solutions for the quasilinear parabolic equation with nonlinear gradient term and L1 data

In this article, we study the quasilinear parabolic problem u t - div ( ∇ u m ∇ u ) + u u β - 2 ∇ u q = u u α - 2 ∇ u p + g ( u ) , x ∈ Ω , t > 0 , u ( x , 0 ) = u 0 ( x ) , x ∈ Ω ; u ( x , t ) = 0 , x ∈ ∂ Ω , t ≥ 0 , where Ω is a bounded domain in ℝN, m > 0 and g(u) satisfies |g(u)| ≤ K1|u|1+ν with 0 ≤ ν < m. By the Moser's technique, we prove that if α, β > 1, 0 ≤ p < q, 1 ≤ q...

Positive solutions for nonlocal fourth-order boundary value problems with all order derivatives

In this article, by the fixed point theorem in a cone and the nonlocal fourth-order BVP's Green function, the existence of at least one positive solution for the nonlocal fourth-order boundary value problem with all order derivatives u ( 4 ) ( t ) + A u ″ ( t ) = λ f ( t , u ( t ) , u ′ ( t ) , u ″ ( t ) , u ‴ ( t ) ) , 0 < t < 1 , u ( 0 ) = u ( 1 ) = ∫ 0 1 p ( s ) u ( s ) d s...

Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice

PurposePyrrole–imidazole (Py-Im) polyamides are programmable, sequence-specific DNA minor groove–binding ligands. Previous work in cell culture has shown that various polyamides can be used to modulate the transcriptional programs of oncogenic transcription factors. In this study, two hairpin polyamides with demonstrated activity against androgen receptor signaling in cell...

A Finite and Instantaneous Screw Based Approach for Topology Design and Kinematic Analysis of 5-Axis Parallel Kinematic Machines

/static/dynamic modeling, analysis and optimal design of parallel mechanisms under framework of screw theory, orthopedics medical robot. Tel: +86‑22‑87402015; E‑mail: . Shuo‑Fei Yang, born in 1988, is

Cx3cr1 deficiency in mice attenuates hepatic granuloma formation during acute schistosomiasis by enhancing the M2-type polarization of macrophages

Acute schistosomiasis is characterized by pro-inflammatory responses against tissue- or organ-trapped parasite eggs along with granuloma formation. Here, we describe studies in Cx3cr1−/− mice and demonstrate the role of Cx3cr1 in the pathoetiology of granuloma formation during acute schistosomiasis. Mice deficient in Cx3cr1 were protected from granuloma formation and hepatic...

Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review

Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review Ruixue Huang,* Ping Ding,* Fei Yang*Department of Occupational and