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Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway

Chen declares that he has no conflict of interest. The author Chen Liu declares that he has no conflict of interest. The author Feng Jin declares that he has no conflict of interest. Ethical approval

Effect of AQP-5 silencing by siRNA interference on chemosensitivity of breast cancer cells

anesthesia , Jiangsu People's h ospital, n anjing, People's republic of china 1 clinical laboratory, suqian First hospital , suqian, People's republic of china 2 Feng Jin cancer center, Daping hospital and

N-Butanol Extract from Melilotus suaveolens Ledeb Affects Pro- and Anti-Inflammatory Cytokines and Mediators

Melilotus suaveolens Ledeb is a traditional medicinal plant for treating inflammation-related disease. This explores the inner anti-inflammatory mechanism of n-butanol extract from M. suaveolens Ledeb. Inflammatory cellular model was established by lipopolysaccharide intervention on RAW264.7 cell line. Levels of secreted cytokines TNF-α, IL-1β, IL-6, NO and IL-10 in supernatant...

Involvement of AMP-activated Protein Kinase (AMPK) in Regulation of Cell Membrane Potential in a Gastric Cancer Cell Line

Membrane potential (Vmem) is a key bioelectric property of non-excitable cells that plays important roles in regulating cell proliferation. However, the regulation of Vmem itself remains largely unexplored. We found that, under nutrient starvation, during which cell division is inhibited, MKN45 gastric cancer cells were in a hyperpolarized state associated with a high...

Numerical study of a sphere descending along an inclined slope in a liquid

The descending process of a sphere rolling and/or sliding along an inclined slope in a liquid involves interactions between the hydrodynamic forces on the sphere and the contact forces between the sphere and the plane. In this study, the descending process of sphere in a liquid was examined using coupled LBM–DEM technique. The effects of slope angle, viscosity and friction...

Effect of pre-annealing treatment on the microstructure and mechanical properties of extruded Al–Zn–Mg–Cu alloy bars

Taking extruded Al–Zn–Mg–Cu alloy (7A04 alloy) bars as the research object, the effect and mechanism of pre-annealing treatments on the microstructure and mechanical properties of the aged alloy bars were investigated. The results show that a pre-annealing treatment at 350°C for 15 h before a T6 treatment substantially reduced the sensitivity of the microstructure and mechanical...

Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

, Jia-rui Yu†2, Zhao Yang†2, Guan-xia Zhu†3, 4, Peng Gao2, Huan Wang2, Si-yuan Chen2, Jie Zhang5, Mei-yue Liu2, Yi Niu2, Xiao-mei Wei2, Wei Wang2, Feng-jin Ye2, Li-xin Zhang2, Yue Zhao3Email author and

8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90α downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells

8u, an acridine derivative, has been proved effective anti-hepatocarcinoma effect, while the underlying mechanism remains unclear. Here, metabolomics and proteomics approaches were applied to study its anti-cancer mechanism and explore its effect on HepG2 cells’ invasion and metastasis abilities. The results showed that 8u significantly suppressed HepG2 cells migration and...

Structural Characterization of Lignin and Its Degradation Products with Spectroscopic Methods

Lignin is highly branched phenolic polymer and accounts 15–30% by weight of lignocellulosic biomass (LCBM). The acceptable molecular structure of lignin is composed with three main constituents linked by different linkages. However, the structure of lignin varies significantly according to the type of LCBM, and the composition of lignin strongly depends on the degradation process...

Structural Characterization of Lignin and Its Degradation Products with Spectroscopic Methods

Lignin is highly branched phenolic polymer and accounts 15–30% by weight of lignocellulosic biomass (LCBM). The acceptable molecular structure of lignin is composed with three main constituents linked by different linkages. However, the structure of lignin varies significantly according to the type of LCBM, and the composition of lignin strongly depends on the degradation process...

Structural Characterization of Lignin and Its Degradation Products with Spectroscopic Methods

Lignin is highly branched phenolic polymer and accounts 15–30% by weight of lignocellulosic biomass (LCBM). The acceptable molecular structure of lignin is composed with three main constituents linked by different linkages. However, the structure of lignin varies significantly according to the type of LCBM, and the composition of lignin strongly depends on the degradation process...

Gene expression meta-analysis in diffuse low-grade glioma and the corresponding histological subtypes

Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaSiqi Wang, Feng Jin, Wenliang Fan, Fang Liu, Yan Zou, Xuehan Hu & Ping HanDepartment of Radiology, Zhongnan Hospital, Wuhan ... journals • PubMed • Google Scholar Search for Feng Jin in:Nature Research journals • PubMed • Google Scholar Search for Wenliang Fan in:Nature Research journals • PubMed • Google Scholar Search for Fang

Alzheimer’s disease and gut microbiota

Alzheimer’s disease (AD) is a most common neurodegenerative disorder, which associates with impaired cognition. Gut microbiota can modulate host brain function and behavior via microbiota-gut-brain axis, including cognitive behavior. Germ-free animals, antibiotics, probiotics intervention and diet can induce alterations of gut microbiota and gut physiology and also host cognitive...

Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway

-dong Yao, Rui Wang, and Feng-jin Guo Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Correspondence should ... be addressed to Feng-jin Guo; nc.ude.umjt.hjt@ougjf Received 12 June 2017; Revised 28 August 2017; Accepted 12 September 2017; Published 27 December 2017 Academic Editor: Indumathi Somasundaram

Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway

Fat infiltration within the bone marrow is easily observed in some postmenopausal women. Those fats are mainly derived from bone marrow mesenchymal stem cells (BMMSCs). The increment of adipocytes derived from BMMSCs leads to decreased osteoblasts derived from BMMSCs, so the bidirectional differentiation of BMMSCs significantly contributes to osteoporosis. Icariin is the main...

Correction: Characterization of long noncoding RNA and messenger RNA signatures in melanoma tumorigenesis and metastasis

, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 , China. There is an error in affiliation 3 for author Feng Jin. Affiliation 3 should be: Department of

Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells

CRISPR/Cas9 technology enables efficient loss-of-function analysis of human genes using somatic cells. Studies of essential genes, however, require conditional knockout (KO) cells. Here, we describe the generation of inducible CRISPR KO human cell lines for the subunits of the telosome/shelterin complex, TRF1, TRF2, RAP1, TIN2, TPP1 and POT1, which directly interact with...

Genistein promotes ionizing radiation-induced cell death by reducing cytoplasmic Bcl-xL levels in non-small cell lung cancer

Genistein (GEN) has been previously reported to enhance the radiosensitivity of cancer cells; however, the detailed mechanisms remain unclear. Here, we report that GEN treatment inhibits the cytoplasmic distribution of Bcl-xL and increases nuclear Bcl-xL in non-small cell lung cancer (NSCLC). Interestingly, our in vitro data show that ionizing radiation IR treatment significantly...

Characterization of long noncoding RNA and messenger RNA signatures in melanoma tumorigenesis and metastasis

The incidence of melanoma, the most aggressive and life-threatening form of skin cancer, has significantly risen over recent decades. Therefore, it is essential to identify the mechanisms that underlie melanoma tumorigenesis and metastasis and to explore novel and effective melanoma treatment strategies. Accumulating evidence s uggests that aberrantly expressed long noncoding...

L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo

Background L-Arg is involved in many biological activities, including the activation of T cells. In breast cancer patients, L-Arg is depleted by nitric oxide synthase 2 (NOS2) and arginase 1 (ARG-1) produced by myeloid-derived suppressor cells (MDSCs). Our aim was to test whether L-Arg supplementation could enhance antitumor immune response and improve survivorship in a rodent...