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Position paper of the Italian Society of Internal Medicine (SIMI) on prophylaxis and treatment of venous thromboembolism in patients with cancer

Cancer patients are at high risk of developing thrombotic events, including venous thromboembolism (VTE) [deep venous thrombosis (DVT) and pulmonary embolism (PE)], and arterial thrombosis. DVT and PE represent the second leading cause of death in cancer patients; moreover, the development of thromboembolic events in cancer patients is linked to a greater need of hospitalization...

Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals

draft: Francesco Andreozzi, Gaia Chiara Mannino. Writing ± review & editing: Francesco Perticone, Giorgio Sesti. 8 / 9 1. Lee JH and Welch DR . Identification of highly expressed genes in metastasis

Association between hemoglobin glycation index with insulin resistance and carotid atherosclerosis in non-diabetic individuals

Hemoglobin glycation index (HGI), defined as the difference between the observed HbA1c value and the value of HbA1c predicted from plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with micro- and macro-vascular complications in subjects with type 2 diabetes. To investigate the...

Association between Noninvasive Fibrosis Markers and Cardio-Vascular Organ Damage among Adults with Hepatic Steatosis

Succurro 0 Francesco Perticone 0 Anna Alisi, Bambino Gesu' Children Hospital, Italy 0 Department of Medical and Surgical Sciences, University ''Magna Graecia'' of Catanzaro , Catanzaro , Italy Evidence

Association between Noninvasive Fibrosis Markers and Chronic Kidney Disease among Adults with Nonalcoholic Fatty Liver Disease

Evidence suggests that nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with an increased risk of chronic kidney disease (CKD). In this study we aimed to evaluate whether the severity of liver fibrosis estimated by NAFLD fibrosis score is associated with higher prevalence of CKD in individuals with NAFLD. To this end NAFLD fibrosis...

Growth Hormone Deficiency Is Associated with Worse Cardiac Function, Physical Performance, and Outcome in Chronic Heart Failure: Insights from the T.O.S.CA. GHD Study

Background Although mounting evidence supports the concept that growth hormone (GH) deficiency (GHD) affects cardiovascular function, no study has systematically investigated its prevalence and role in a large cohort of chronic heart failure (CHF) patients. Aim of this study is to assess the prevalence of GHD in mild-to-moderate CHF and to explore clinical and functional...

Low dose of acetylsalicylic acid and oxidative stress-mediated endothelial dysfunction in diabetes: a short-term evaluation

, Vincenzo Mollace, Giorgio Sesti and Francesco Perticone declare that they have no conflict of interest. Human and animal rights All procedures followed were in accordance with the ethical standards of the

Association of Insulin Resistance Indexes to Carotid Intima–Media Thickness

Objectives Accumulating evidence suggests an association between insulin resistance (IR) and cardiovascular diseases The aim of this study was to examine the relationship between indexes of IR and common carotid intima–media thickness (IMT), an indicator of vascular damage. Methods In 847 non-diabetic Caucasians a 75 g oral glucose tolerance test was performed and surrogate...

A Fasting Insulin–Raising Allele at IGF1 Locus Is Associated with Circulating Levels of IGF-1 and Insulin Sensitivity

BackgroundA meta-analysis of genome-wide data reported the discovery of the rs35767 polymorphism near IGF1 with genome-wide significant association with fasting insulin levels. However, it is unclear whether the effects of this polymorphism on fasting insulin are mediated by a reduced insulin sensitivity or impaired insulin clearance. We investigated the effects of the rs35767...

Vitamin D and 1-hour post-load plasma glucose in hypertensive patients

Background A plasma glucose value ≥155 mg/dl for 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify subjects with normal glucose tolerance (NGT) at high-risk for type-2 diabetes and with subclinical organ damage. We designed this study to address if 25-hydroxyvitamin D [25(OH)D] circulating levels are associated with glucose tolerance...

Decreased Insulin Clearance in Individuals with Elevated 1-h Post-Load Plasma Glucose Levels

Reduced insulin clearance has been shown to predict the development of type 2 diabetes. Recently, it has been suggested that plasma glucose concentrations ≥8.6 mmol/l (155 mg/dl) at 1 h during an oral glucose tolerance test (OGTT) can identify individuals at high risk for type 2 diabetes among those who have normal glucose tolerance (NGT 1 h-high). The aim of this study was to...

Serum Uric Acid and 1-h Postload Glucose in Essential Hypertension

FRANCESCO PERTICONE ANGELA SCIACQUA MARIA PERTICONE FRANCO ARTURI PAOLA ELISA SCARPINO MICHELE QUERO GIORGIO SESTI C a r d i o v a s c u l a r a n d OBJECTIVEdSubjects who are normal glucose

Association between One-Hour Post-Load Plasma Glucose Levels and Vascular Stiffness in Essential Hypertension

Franco Arturi 0 Giorgio Sesti 0 Francesco Perticone 0 Melania Manco, Scientific Directorate, Bambino Hospital, Italy 0 Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro

One-Hour Postload Plasma Glucose Levels and Left Ventricular Mass in Hypertensive Patients

ANGELA SCIACQUA SOFIA MICELI GIUSEPPE CARULLO LAURA GRECO ELENA SUCCURRO FRANCO ARTURI GIORGIO SESTI FRANCESCO PERTICONE C a r d i o v a s c u l a r OBJECTIVE-Left ventricular hypertrophy (LVH), an

Cardiometabolic Risk Profiles and Carotid Atherosclerosis in Individuals With Prediabetes Identified by Fasting Glucose, Postchallenge Glucose, and Hemoglobin A1c Criteria

MARIA A. MARINI ELENA SUCCURRO ERSILIA CASTALDO SABRINA CUFONE FRANCO ARTURI PHD ANGELA SCIACQUA RENATO LAURO MARTA L. HRIBAL PHD FRANCESCO PERTICONE GIORGIO SESTI C a r d i o v a s c u l a r a n d

Insulin Sensitivity, β-Cell Function, and Incretin Effect in Individuals With Elevated 1-Hour Postload Plasma Glucose Levels

MARIA A. MARINI ELENA SUCCURRO SIMONA FRONTONI SIMONA MASTROIANNI FRANCO ARTURI PHD ANGELA SCIACQUA RENATO LAURO MARTA L. HRIBAL PHD FRANCESCO PERTICONE GIORGIO SESTI C a r d i o v a s c u l a r