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Salmon Dip

Salmon Dip Brian G. Meyer 0 1 0 This Article is brought to you for free and open access by the College of Agriculture and Life Sciences at Iowa State University Digital Repository. It has been

Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose

grateful to John C. W. Carroll for help creating figures, and Dr. Matthew Hirschey for helpful discussions. Data curation: Jesse G. Meyer. Formal analysis: Jesse G. Meyer. Funding acquisition: Eric Verdin ... , Christopher B. Newgard, C. Ronald Kahn. Investigation: Jesse G. Meyer, Olga Ilkayeva. Methodology: Jesse G. Meyer, Samir Softic, Nathan Basisty, Bradford W. Gibson. Project administration: Jesse G. Meyer

Side-to-side asymmetries in landing mechanics from a drop vertical jump test are not related to asymmetries in knee joint laxity following anterior cruciate ligament reconstruction

Purpose Asymmetries in knee joint biomechanics and increased knee joint laxity in patients following anterior cruciate ligament reconstruction (ACLR) are considered risk factors for re-tear or early onset of osteoarthritis. Nevertheless, the relationship between these factors has not been established. The aim of the study was to compare knee mechanics during landing from a...

Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease

Complement is an essential element in both innate and acquired immunity contributing to the immunopathogenesis of many disorders, including Chagas Disease (CD). Human complement receptor 1 (CR1) plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Distinct CR1 exon 29 variants have been found associated with...

HDV infection rates in northern Vietnam

Tropical Medicine, University of Tübingen, Tübingen, GermanyMai Thanh Binh, Nghiem Xuan Hoan, Hoang Van Tong, Christian G. Meyer, Peter G. Kremsner & Thirumalaisamy P. VelavanVietnamese-German Center for ... Excellence in Medical Research, Hanoi, VietnamMai Thanh Binh, Nghiem Xuan Hoan, Hoang Van Tong, Dao Phuong Giang, Bui Tien Sy, Nguyen Linh Toan, Le Huu Song, Christian G. Meyer & Thirumalaisamy P. Velavan108

Site-specific identification and quantitation of endogenous SUMO modifications under native conditions

. Lumpkin, Alla S. Ahmad, Jesse G. Meyer & Elizabeth A. KomivesProteomic Service Group Cell Signaling Technology, 3 Trask Lane, Danvers, MA, 01923, USAHongbo Gu & Yiying ZhuCell and Developmental Biology ... . Clauser in:Nature Research journals • PubMed • Google Scholar Search for Jesse G. Meyer in:Nature Research journals • PubMed • Google Scholar Search for Eric J. Bennett in:Nature Research journals

The Proposed Park in Maine's North Woods: Preferences of Out-of-State Visitors

The proposal to create a new national park and national recreation area in northern Maine has met with much support and also much opposition from within Maine. Over 90 percent of overnight visitors to Maine recreation sites come from out of state but currently there is no information about out-of-state visitors’ preferences for the proposed park. Our research contributes to...

Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin

We have carried out a comprehensive analysis of the determinants of human influenza A H3 hemagglutinin evolution. We consider three distinct predictors of evolutionary variation at individual sites: solvent accessibility (as a proxy for protein fold stability and/or conservation), Immune Epitope Database (IEDB) epitope sites (as a proxy for host immune bias), and proximity to the...

Unexpected Positive Buoyancy in Deep Sea Sharks, Hexanchus griseus, and a Echinorhinus cookei

We do not expect non air-breathing aquatic animals to exhibit positive buoyancy. Sharks, for example, rely on oil-filled livers instead of gas-filled swim bladders to increase their buoyancy, but are nonetheless ubiquitously regarded as either negatively or neutrally buoyant. Deep-sea sharks have particularly large, oil-filled livers, and are believed to be neutrally buoyant in...

Constrained Optimization for Addressing Forest-Wide Timber Production

Optimization models are important tools for integrating objectives in forest management planning. Timber management objectives are difficult to address without considering complex environmental conditions, other ownership objectives, and forest management policies. Typically, to learn about management opportunities, model applications involve multiple scenarios and tradeoff...

Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH)

Post-translational modification of lysine residues by NƐ-acylation is an important regulator of protein function. Many large-scale protein acylation studies have assessed relative changes of lysine acylation sites after antibody enrichment using mass spectrometry-based proteomics. Although relative acylation fold-changes are important, this does not reveal site occupancy, or...

TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis

Toll like receptors (TLR) are key elements of the innate immune response and involved in the recognition of pathogens. To test common and rare TLR variants involved in susceptibility or resistance to infection with Mycobacterium tuberculosis we screened the exons of the genes encoding TLR 1, 2, 4, and the adaptor molecule TIRAP in more than 4500 tuberculosis (TB) cases and...

A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients

The contribution of interleukin- (IL-) 4 receptor-alpha- (Rα-) dependent events in the pathogenesis of tuberculosis (TB) is controversial. We have recently shown IL-13 overexpression in mice to cause recrudescent Mtb replication and centrally necrotizing granulomas strongly resembling pathology of human TB. A deletion of IL-4Rα completely abrogates TB tissue pathology in these...

A Way Forward for Healthcare in Madagascar?

A healthcare utilization survey was conducted as a component of the Typhoid Fever Surveillance in Africa Program (TSAP). The findings of this survey in Madagascar contrasted with those in other sites of the program; namely, only 30% of the population sought healthcare at the government-provided healthcare facilities for fever. These findings promoted us to determine the drivers...

Evidence base in guideline generation in diabetes

G. Meyer Faculty of Health, University of Witten/Herdecke , Witten , Germany 2 ) Unit of Health Sciences and Education, University of Hamburg , Martin-Luther-King Platz 6, 20146 Hamburg , Germany ... of the IQWiG from January 2005 until January 2013 and G. Meyer is currently member. Contribution statement IM and GM are equally responsible for the conception, design and drafting of the manuscript

abiliti® Closed-Loop Gastric Electrical Stimulation System for Treatment of Obesity: Clinical Results with a 27-Month Follow-Up

Background The aim of the study was to evaluate the safety and effectiveness of a novel closed-loop gastric electric stimulation device (abiliti® system) featuring a transgastric sensor to detect food intake and an accelerometer to record physical activity to induce and maintain lifestyle changes to treat obesity. Methods In a prospective, multi-center study, 34 obese subjects...

Geographical distribution of complement receptor type 1 variants and their associated disease risk

Background Pathogens exert selective pressure which may lead to substantial changes in host immune responses. The human complement receptor type 1 (CR1) is an innate immune recognition glycoprotein that regulates the activation of the complement pathway and removes opsonized immune complexes. CR1 genetic variants in exon 29 have been associated with expression levels, C1q or C3b...

Integrating Sequence Variation and Protein Structure to Identify Sites under Selection

We present a novel method to identify sites under selection in protein-coding genes. Our method combines the traditional Goldman–Yang model of coding-sequence evolution with the information obtained from the 3D structure of the evolving protein, specifically the relative solvent accessibility (RSA) of individual residues. We develop a random-effects likelihood sites model in...

Predicting Growth Conditions from Internal Metabolic Fluxes in an In-Silico Model of E. coli

A widely studied problem in systems biology is to predict bacterial phenotype from growth conditions, using mechanistic models such as flux balance analysis (FBA). However, the inverse prediction of growth conditions from phenotype is rarely considered. Here we develop a computational framework to carry out this inverse prediction on a computational model of bacterial metabolism...