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Search: authors:"Gaetano Serviddio"

6 papers found.
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Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer’s disease by exerting anti-inflammatory and neuroprotective effects

• Google Scholar Search for Luca Ferraro in:Nature Research journals • PubMed • Google Scholar Search for Kevin Donald Broad in:Nature Research journals • PubMed • Google Scholar Search for Gaetano ... Serviddio in:Nature Research journals • PubMed • Google Scholar Search for Francesco Bellanti in:Nature Research journals • PubMed • Google Scholar Search for Gianmauro Palombelli in:Nature Research

DAAs Rapidly Reduce Inflammation but Increase Serum VEGF Level: A Rationale for Tumor Risk during Anti-HCV Treatment

Background Novel direct-acting antivirals (DAAs) have completely changed the panorama of hepatitis C due to their high efficacy and optimal safety profile. Unfortunately, an unexpectedly high rate of early recurrence of hepatocellular carcinoma has been reported within weeks of starting treatment, but the mechanism is not known. Methods We monitored the serum level of vascular...

Obese Rats Exhibit High Levels of Fat Necrosis and Isoprostanes in Taurocholate-Induced Acute Pancreatitis

Background Obesity is a prognostic factor for severity in acute pancreatitis in humans. Our aim was to assess the role of oxidative stress and abdominal fat in the increased severity of acute pancreatitis in obese rats. Methodology Taurocholate-induced acute pancreatitis was performed in lean and obese Zucker rats. Levels of reduced glutathione, oxidized glutathione, L-cysteine...

Oxidation of Hepatic Carnitine Palmitoyl Transferase-I (CPT-I) Impairs Fatty Acid Beta-Oxidation in Rats Fed a Methionine-Choline Deficient Diet

There is growing evidence that mitochondrial dysfunction, and more specifically fatty acid β-oxidation impairment, is involved in the pathophysiology of non-alcoholic steatohepatitis (NASH). The goal of the present study was to achieve more understanding on the modification/s of carnitinepalmitoyltransferase-I (CPT-I), the rate-limiting enzyme of the mitochondrial fatty acid...

Postconditioning is an effective strategy to reduce renal ischaemia/reperfusion injury

Background. Several recent studies have shown that a brief ischaemia applied during the onset of reperfusion (postconditioning) is cardioprotective in different animal models. The potential application of postconditioning to organs different from the heart, i.e. kidney, is not available and is investigated in the present study. We also tested the hypothesis that mitochondria play...

RNAPol-ChIP: a novel application of chromatin immunoprecipitation to the analysis of real-time gene transcription

Present addresses: Gaetano Serviddio, Dipartimento di Scienze Mediche e del Lavoro, Universita` di Foggia , Foggia, Italy Abedelhalim Boukaba, Wellcome Trust Centre for Cell Biology , ICMB. 6.33 Swann