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32 papers found.
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Enrichment of genetic markers of recent human evolution in educational and cognitive traits

Higher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing complexity of material culture artefacts. However, the molecular genetic factors involved in the evolution are still relatively unexplored. Here, we investigated...

GWAS on family history of Alzheimer’s disease

. EvansCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UKRiccardo E. Marioni, Sarah E. Harris, Saskia P. Hagenaars, W. David Hill, Gail Davies, Catharine R ... . David Hill in:Nature Research journals • PubMed • Google Scholar Search for Gail Davies in:Nature Research journals • PubMed • Google Scholar Search for Craig W. Ritchie in:Nature Research journals

Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes

, Saskia P. Hagenaars, Simon R. Cox, William David Hill, Gail Davies, Sarah E. Harris, Ian J. Deary, David M. Evans, Nicholas G. Martin, Margaret J. Wright, and Timothy C. Bates declare that they have no

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression...

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank

Few replicable genetic associations for Major Depressive Disorder (MDD) have been identified. Recent studies of MDD have identified common risk variants by using a broader phenotype definition in very large samples, or by reducing phenotypic and ancestral heterogeneity. We sought to ascertain whether it is more informative to maximize the sample size using data from all available...

Ageing and brain white matter structure in 3,513 UK Biobank participants

Quantifying the microstructural properties of the human brain’s connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64–77.12 years from the UK Biobank. Using conventional water diffusion measures and newer, rarely studied indices from neurite...

The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability

Riccardo E. Marioni Lars Penke Gail Davies Jennifer E. Huffman Caroline Hayward Ian J. variants is not associated with childhood or late-life cognitive Articles on similar topics can be found in the

Alcohol consumption and lifetime change in cognitive ability: a gene × environment interaction study

Studies of the effect of alcohol consumption on cognitive ability are often confounded. One approach to avoid confounding is the Mendelian randomization design. Here, we used such a design to test the hypothesis that a genetic score for alcohol processing capacity moderates the association between alcohol consumption and lifetime change in cognitive ability. Members of the...

Complex Variation in Measures of General Intelligence and Cognitive Change

Combining information from multiple SNPs may capture a greater amount of genetic variation than from the sum of individual SNP effects and help identifying missing heritability. Regions may capture variation from multiple common variants of small effect, multiple rare variants or a combination of both. We describe regional heritability mapping of human cognition. Measures of...

Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions

Differences in general cognitive function have been shown to be partly heritable and to show genetic correlations with several psychiatric and physical disease states. However, to date, few single-nucleotide polymorphisms (SNPs) have demonstrated genome-wide significance, hampering efforts aimed at determining which genetic variants are most important for cognitive function and...

Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936

Alzheimer's disease patients have deficits in specific cognitive domains, and susceptibility genes for this disease may influence human cognition in nondemented individuals. To evaluate the role of Alzheimer's disease-linked genetic variation on cognition and normal cognitive ageing, we investigated two Scottish cohorts for which assessments in major cognitive domains are...

Functional Gene Group Analysis Indicates No Role for Heterotrimeric G Proteins in Cognitive Ability

Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies...

Assessing the genetic overlap between BMI and cognitive function

Debette, Maaike Schuur, Albert V Smith, Gail Davies, David A Bennett, Ian J Deary, M Arfan Ikram, Lenore J Launer, Annette L Fitzpatrick, Sudha Seshadri, Cornelia M van Duijn & Thomas H Mosely Jr CHARGE ... Cognitive Working Group The members of the CHARGE Cognitive Working Group Consortium are Carla A Ibrahim-Verbaas, Jan Bressler, Stephanie Debette, Maaike Schuur, Albert V Smith, Gail Davies, David A Bennett

Genetic Basis of a Cognitive Complexity Metric

Relational complexity (RC) is a metric reflecting capacity limitation in relational processing. It plays a crucial role in higher cognitive processes and is an endophenotype for several disorders. However, the genetic underpinnings of complex relational processing have not been investigated. Using the classical twin model, we estimated the heritability of RC and genetic overlap...

Genetic Copy Number Variation and General Cognitive Ability

Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low...

Genome-wide association studies identify genetic loci for low von Willebrand factor levels

Wendy L McArdle 13 Folkert W Asselbergs 14 15 Ming-Huei Chen 7 Lorna M Lopez 16 18 Jennifer E Huffman 0 Frank WG Leebeek 9 Saonli Basu 11 David J Stott 1 Ann Rumley 2 Ron T Gansevoort 3 Gail Davies 4 16

Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts

has previously published under her maiden name Lorna M Houlihan. AffiliationsDepartment of Psychology, The University of Edinburgh, Edinburgh, UKLorna M Lopez, Michelle Luciano, Gail Davies, Alan J Gow ... in:Nature Research journals • PubMed • Google ScholarSearch for Dave Liewald in:Nature Research journals • PubMed • Google ScholarSearch for Gail Davies in:Nature Research journals • PubMed • Google

Investigation of NOD1/CARD4 variation in inflammatory bowel disease using a haplotype-tagging strategy

Both NOD1/CARD4 and NOD2/CARD15 are intracellular pattern-recognition receptors involved in the innate immune response. Germline NOD2/CARD15 variation has a definite effect on susceptibility to Crohn's disease (CD) and phenotype, although this contribution is weak in Scotland and Scandinavia. The NOD1/CARD4 gene lies within the putative inflammatory bowel disease (IBD) locus at...