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38 papers found.
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Strong Coupling between a Quasi-single Molecule and a Plasmonic Cavity in the Trapping System

We theoretically investigate the strong coupling phenomenon between a quasi-single molecule and a plasmonic cavity based on the blue-detuned trapping system. The trapping system is made up of a metallic nanohole array. A finite-difference time-domain method is employed to simulate the system, and the molecule is treated as a dipole in simulations. By calculating the...

Heterogeneous mutation pattern in tumor tissue and circulating tumor DNA warrants parallel NGS panel testing

Liquid biopsy by genotyping circulating tumor DNA (ctDNA) has provided a non-invasive approach in assessing tumor genomic alterations in clinical oncology. However, emerging evidence in clinical settings has shown significant discordance in the genomic alterations between matched tumor tissue and blood ctDNA samples, and even between the same set of blood samples analyzed on...

Amplification of overlapping DNA amplicons in a single-tube multiplex PCR for targeted next-generation sequencing of BRCA1 and BRCA2

Current PCR-based target enrichment methods for next generation sequencing (NGS) of overlapping amplicons often requires separate PCR reactions and subsequent pooling of amplicons from the different reactions. The study presents a novel method, deemed stem-loop inhibition mediated amplification (SLIMamp), for amplifying overlapping or tiled amplicons in a single multiplex PCR...

Phosphoinositide-specific phospholipase Cγ1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells

Yanyan Zhan Gang Song Tianhui Hu Chun Xia Bing Zhang OPEN Published: xx xx xxxx Phosphoinositide-specific phospholipase C (PLC) ?1 has been reported to be involved in cancer cell proliferation and

Evaluation of efficacy of transcatheter arterial chemoembolization for hepatocellular carcinoma using magnetic resonance diffusion-weighted imaging

Evaluation of efficacy of transcatheter arterial chemoembolization for hepatocellular carcinoma using magnetic resonance diffusion-weighted imaging Xiao-Ming Wu,1 Jun-Feng Wang,1 Jian-Song Ji,2 Ming-Gao Chen,1 Jian-Gang Song1 1Department of Radiology, Jinhua People’s Hospital, Jinhua, 2Department of Radiology, Lishui Municipal Center Hospital, Lishui, People’s Republic of China...

Kinetic study of a β-mannanase from the Bacillus licheniformis HDYM-04 and its decolorization ability of twenty-two structurally different dyes

Background The microbial β-mannanases have been increasingly exploited for bioconversion of biomass materials and various potential industrial applications, such as bleaching of softwood pulps, scouring and desizing, food and feed additive, and oil and textile industries. In this paper, a β-mannanase was characterization from the bacteria, Bacillus licheniformis HDYM-04, which...

Evolution of body morphology and beak shape revealed by a morphometric analysis of 14 Paridae species

Background Morphological characters of birds reflect their adaptive evolution and ecological requirements and are also relevant to phylogenetic relationships within a group of related species. The tits (Paridae) are known to be outwardly homogeneous in shape, with one aberrant member, the Ground Tit (Pseudopodoces humilis), which is quite different from its relatives in both body...

Evolution of body morphology and beak shape revealed by a morphometric analysis of 14 Paridae species

Morphological characters of birds reflect their adaptive evolution and ecological requirements and are also relevant to phylogenetic relationships within a group of related species. The tits (Paridae) are known to be outwardly homogeneous in shape, with one aberrant member, the Ground Tit (Pseudopodoces humilis), which is quite different from its relatives in both body morphology...

Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level

Background The poor prognosis and the limited efficacy of targeted therapy in patients with triple-negative breast cancer (TNBC) have raised the need for alternative therapies. Recent studies have demonstrated that folate receptor-alpha (FRα) may represent an ideal tumor-associated marker for immunotherapy for TNBC. Methods The aim of the present study was to apply a chimeric...

Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level

The poor prognosis and the limited efficacy of targeted therapy in patients with triple-negative breast cancer (TNBC) have raised the need for alternative therapies. Recent studies have demonstrated that folate receptor-alpha (FRα) may represent an ideal tumor-associated marker for immunotherapy for TNBC. The aim of the present study was to apply a chimeric antigen receptor (CAR...

BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1

Scholar Search for Jonathan C. Zhao in:Nature Research journals • PubMed • Google Scholar Search for Gang Song in:Nature Research journals • PubMed • Google Scholar Search for Wenyi Mi in:Nature Research

Research and Application of FTA and Petri Nets in Fault Diagnosis in the Pantograph-Type Current Collector on CRH EMU Trains

A fault tree is established based on structural analysis, working principle analysis, and failure mode and effects analysis (FMEA) of the pantograph-type current collector on the Chinese Rail High-Speed Electric Multiple Unit (CRH EMU) train. To avoid the deficiencies of fault tree analysis (FTA), Petri nets modelling is used to address the problem of data explosion and carry out...

Efficacy analysis of tyrosine kinase inhibitors on rare non-small cell lung cancer patients harboring complex EGFR mutations

of Pathology, Chinese PLA General Hospital, Beijing 100853, ChinaZhi-Gang Song AuthorsSearch for Liang Peng in:Nature Research journals • PubMed • Google ScholarSearch for Zhi-Gang Song in:Nature

Autologous platelet lysates local injections for treatment of tibia non-union with breakage of the nickelclad: a case report

BackgroundNonunions of the tibia represent challenging orthopedic problems, which require the surgeon to analyze numerous factors and choose an appropriate treatment. This article presents a case report of tibia and fibula fracture patient who failed the internal fixation surgery and successfully recovered after one course of percutaneous autologous platelet lysates injection...

Damage Identification of Bridge Based on Modal Flexibility and Neural Network Improved by Particle Swarm Optimization

An approach to identify damage of bridge utilizing modal flexibility and neural network optimized by particle swarm optimization (PSO) is presented. The method consists of two stages; modal flexibility indices are applied to damage localizing and neural network optimized by PSO is used to identify the damage severity. Numerical simulation of simply supported bridge is presented...

Damage Identification of Bridge Based on Modal Flexibility and Neural Network Improved by Particle Swarm Optimization

An approach to identify damage of bridge utilizing modal flexibility and neural network optimized by particle swarm optimization (PSO) is presented. The method consists of two stages; modal flexibility indices are applied to damage localizing and neural network optimized by PSO is used to identify the damage severity. Numerical simulation of simply supported bridge is presented...

Fuzzy Neural Network-Based Damage Assessment of Bridge under Temperature Effect

Vibration-based method has been widely applied for damage identification of bridge. Natural frequency, mode shape, and their derivatives are sensitive parameters to damage. However, these parameters can be affected not only by the health of structure, but also by the changing temperature. It is essential to eliminate the influence of temperature in practice. Therefore, a fuzzy...

Fuzzy Neural Network-Based Damage Assessment of Bridge under Temperature Effect

Vibration-based method has been widely applied for damage identification of bridge. Natural frequency, mode shape, and their derivatives are sensitive parameters to damage. However, these parameters can be affected not only by the health of structure, but also by the changing temperature. It is essential to eliminate the influence of temperature in practice. Therefore, a fuzzy...

Bid-overexpression regulates proliferation and phosphorylation of Akt and MAPKs in response to etoposide-induced DNA damage in hepatocellular carcinoma cells

Bid-overexpression regulates proliferation and phosphorylation of Akt and MAPKs in response to etoposide-induced DNA damage in hepatocellular carcinoma cells Yuanyue Li,1 Congjie Dai,2 Juan Li,3 Weiwei Wang,3 Gang Song31Fisheries College, Jimei University, Fujian, China; 2School of Chemical and Life Science, Quanzhou Normal University, Fujian, China; 3Cancer Research Center...

Ginsenoside Metabolite Compound K Promotes Recovery of Dextran Sulfate Sodium-Induced Colitis and Inhibits Inflammatory Responses by Suppressing NF-κB Activation

Phytogenic compounds with anti-oxidant and anti-inflammatory properties, such as ginsenoside metabolite compound K (CK) or berberine (BBR), are currently discussed as promising complementary agents in the prevention and treatment of cancer and inflammation. The latest study showed that ginsenoside Rb1 and its metabolites could inhibit TNBS-induced colitis injury. However, the...