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Evaluating gut microbiota profiles from archived fecal samples

Associations between colorectal cancer and microbiota have been identified. Archived fecal samples might be valuable sample sources for investigating causality in carcinogenesis and biomarkers discovery due to the potential of performing longitudinal studies. However, the quality, quantity and stability of the gut microbiota in these fecal samples must be assessed prior to such...

Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening

Background:To reduce colorectal cancer (CRC) mortality through population-based screening programmes using faecal tests, it is important that individuals continue to participate in the repeated rounds of screening. We aimed to identify lifestyle predictors for discontinuation of faecal immunochemical test (FIT) screening after the first round, as well as lifestyle predictors for...

Methods to Estimate the Comparative Effectiveness of Clinical Strategies that Administer the Same Intervention at Different Times

she has no conflict of interest. James M. Robins declares that he has no conflict of interest. Geir Hoff declares that he has no conflict of interest. Miguel A. Hernán declares that he has no

Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis

,1 Eline Aas,2,3 Marte Lie Høivik,4 Ebbe Langholz,5 Selwyn Odes,6 Milada Småstuen,7 Reinhold Stockbrugger,8 Geir Hoff,9 Bjørn Moum,4 and Tomm Bernklev9 1Department of Gastroenterology, Telemark

Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis

,1 Eline Aas,2,3 Marte Lie Høivik,4 Ebbe Langholz,5 Selwyn Odes,6 Milada Småstuen,7 Reinhold Stockbrugger,8 Geir Hoff,9 Bjørn Moum,4 and Tomm Bernklev9 1Department of Gastroenterology, Telemark

Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis

,1 Eline Aas,2,3 Marte Lie Høivik,4 Ebbe Langholz,5 Selwyn Odes,6 Milada Småstuen,7 Reinhold Stockbrugger,8 Geir Hoff,9 Bjørn Moum,4 and Tomm Bernklev9 1Department of Gastroenterology, Telemark

Bounding the per-protocol effect in randomized trials: an application to colorectal cancer screening

Background The per-protocol effect is the effect that would have been observed in a randomized trial had everybody followed the protocol. Though obtaining a valid point estimate for the per-protocol effect requires assumptions that are unverifiable and often implausible, lower and upper bounds for the per-protocol effect may be estimated under more plausible assumptions...

Do no harm: no psychological harm from colorectal cancer screening

Background:Participation in cancer screening programmes might cause worries in the population outweighting the benefits of reduced mortality. The present study aimed to investigate possible psychological harm of participation in a colorectal cancer (CRC) screening pilot in Norway.Methods:In a prospective, randomised trial participants (aged 50–74 years) were invited to either...

"Drop in" gastroscopy outpatient clinic - experience after 9 months

Background Logistics handling referrals for gastroscopy may be more time consuming than the examination itself. For the patient, "drop in" gastroscopy may reduce uncertainty, inadequate therapy and time off work. Methods After an 8-9 month run-in period we asked patients, hospital staff and GPs to fill in a questionnaire to evaluate their experience with "drop in" gastroscopy and...

"Drop in

Logistics handling referrals for gastroscopy may be more time consuming than the examination itself. For the patient, "drop in

The Science and Politics of Colorectal Cancer Screening

Cancer Research , Oslo , Norway. Geir Hoff is also at the Telemark Hospital , Skien , Norway. Michael Bretthauer is also at the Department of Medicine, Rikshospitalet University Hospital , Oslo , Norway

A Tissue-Based Comparative Effectiveness Analysis of Biomarkers for Early Detection of Colorectal Tumors

OBJECTIVES:We recently identified a six-gene methylation-based biomarker panel suitable for early detection of colorectal cancer (CRC). In this study, we compared the performance of this novel epi-panel with that of previously identified DNA methylation markers in the same clinical tissue sample sets.METHODS:Quantitative methylation-specific PCR was used to analyze the promoter...

Improved breast cancer survival following introduction of an organized mammography screening program among both screened and unscreened women: a population-based cohort study

Introduction Mammography screening reduces breast cancer mortality through earlier diagnosis but may convey further benefit if screening is associated with optimized treatment through multidisciplinary medical care. In Norway, a national mammography screening program was introduced among women aged 50 to 69 years during 1995/6 to 2004. Also during this time, multidisciplinary...

Lifestyle as a predictor for colonic neoplasia in asymptomatic individuals

-drafted the manuscript. Kari Almendingen co-designed the study, supervised the nutritional parts of the study, and gave critical comments to the manuscript. Geir Hoff had the idea and designed the study. He

Lifestyle as a predictor for colonic neoplasia in asymptomatic individuals

Almendingen co-designed the study, supervised the nutritional parts of the study, and gave critical comments to the manuscript. Geir Hoff had the idea and designed the study. He supervised and co-drafted the

Gastronet survey on the use of one- or two-person technique for colonoscopy insertion

Background Usually, colonoscopy insertion is performed by the colonoscopist (one-person technique). Quite common in the early days of endoscopy, the assisting nurse is now only rarely doing the insertion (two-person technique). Using the Norwegian national endoscopy quality assurance (QA) programme, Gastronet, we wanted to explore the extent of two-person technique practice and...

Gastronet survey on the use of one- or two-person technique for colonoscopy insertion

Usually, colonoscopy insertion is performed by the colonoscopist (one-person technique). Quite common in the early days of endoscopy, the assisting nurse is now only rarely doing the insertion (two-person technique). Using the Norwegian national endoscopy quality assurance (QA) programme, Gastronet, we wanted to explore the extent of two-person technique practice and look into...

Quality control in colorectal cancer screening: Systematic microbiological investigation of endoscopes used in the NORCCAP (Norwegian Colorectal Cancer Prevention) trial

to the manuscript. Geir Hoff had the idea and designed the study. He supervised the sampling of data at the screening centres, and codrafted the manuscript. Rex D , Johnson DA , Lieberman DA , Burt