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Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy

As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote...

Overexpression of FRAT1 Is Associated with Malignant Phenotype and Poor Prognosis in Human Gliomas

Academic Editor: Vincent Sapin Copyright © 2015 Geng Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and ... role in the Wnt/β-catenin pathway remain to be further investigated. Conflict of Interests The authors declare that they have no conflict of interests. Authors’ Contribution Geng Guo and Yuan-li Zhao

Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax

assay, AnnexinV/PI analysis, Colony formation assay, and drafted the manuscript. Wei Zhang, Geng Guo, and Xinggang Mao participated in the design of the study and performed the statistical analysis. Xiang

Preparation of a Counter Electrode with P-Type NiO and Its Applications in Dye-Sensitized Solar Cell

This study investigates the applicability of a counter electrode with a P-type semiconductor oxide (such as NiO) on a dye-sensitized solar cell (DSSC). The counter electrode is fabricated by depositing an NiO film on top of a Pt film, which has been deposited on a Fluorine-doped tin oxide (FTO) glass using an ion-sputtering coater (or E-beam evaporator), using a simple spin...

Knockdown of FRAT1 Expression by RNA Interference Inhibits Human Glioblastoma Cell Growth, Migration and Invasion

Background FRAT1 positively regulates the Wnt/β-catenin signaling pathway by inhibiting GSK-3-mediated phosphorylation of β-catenin. It was originally characterized as a protein frequently rearranged in advanced T cell lymphoma, but has recently also been identified as a proto-oncogene involved in tumorigenesis. Our previous studies showed that FRAT1 was dramatically...

Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors

, Geng Guo, Peng Wang, Wei Zhang & Jun-li HuoDepartment of Orthopaedic Surgery, Xijing Hospital, Institute of Orthopaedics and Traumatology of PLA of China, The Fourth Military Medical University, Xi’an ... Xiang Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Hong-gang Ren in:Nature Research journals • PubMed • Google ScholarSearch for Geng Guo in:Nature Research journals • PubMed