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Real-World Outcomes with Lomitapide Use in Paediatric Patients with Homozygous Familial Hypercholesterolaemia

hypercholesterolaemia Lipidology Lomitapide Low-density lipoprotein cholesterol Paediatric Real-world data Patient cases  Tawfeg Ben-Omran, Luis Masana, Genovefa Kolovou, Gema Ariceta, F. Javier Nóvoa, Allan M. Lund ... advisory fees from Amgen, Sanofi, MSD, Myland and Daichii Sankyo. Genovefa Kolovou has given talks, attended conferences sponsored by Amgen, Angelini, MSD, Lilly, Vianex and Sanofi. Martin P. Bogsrud

Cardiovascular magnetic resonance imaging: clinical implications in the evaluation of connective tissue diseases

Loukia Koutsogeorgopoulou 0 Genovefa Kolovou 1 0 Department of Pathophysiology, Laikon Hospital , Athens , Greece 1 Onassis Cardiac Surgery Center , Athens , Greece Cardiovascular magnetic resonance

The Sphinx’s riddle: cardiovascular involvement in autoimmune rheumatic disease

Factors leading to Cardiovascular Disease (CVD) in Autoimmune Rheumatic Diseases (ARD) include: a) atherosclerosis and macro-microvascular coronary artery disease b) pericardial, myocardial and vascular inflammation c) heart valve disease d) heart failure and e) pulmonary hypertension. Cardiology utilizes various non-invasive imaging modalities, such as rest/stress...

Assessment of the Validity and Reproducibility of a Novel Standardized Test Meal for the Study of Postprandial Triacylglycerol Concentrations

Lipotest® is a standardized fat-rich meal designed for use as a test meal during a fat tolerance test (FTT) for the study of postprandial triacylglycerol (TAG) concentrations. Herein we examined the precision and reproducibility of examination using Lipotest® on postprandial TAG levels. A total of 26 healthy consenting subjects were examined twice after 8–10 h fasting with an...

Evaluating the glucose raising effect of established loci via a genetic risk score

, Panagiotis Deloukas. Resources: Anastasia Thanopoulou, Eleftheria Zeggini. 9 / 11 Supervision: Fragiskos Gonidakis, Genovefa Kolovou, Vassilis Kontaxakis, Loukianos Rallidis, Nikolaos Tentolouris, Anastasia ... & editing: Eirini Marouli, Stavroula Kanoni, Vasiliki Mamakou, Sophie Hackinger, Lorraine Southam, Bram Prins, Angela Rentari, Maria Dimitriou, Eleni Zengini, Fragiskos Gonidakis, Genovefa Kolovou, Vassilis

No se requiere ayuno para la determinacion rutinaria del perfil lipidico: implicaciones clinicas y de laboratorio, incluyendo valores de corte deseables - Declaracion de consenso conjunta de la European Atherosclerosis Society y la European Federation of Clinical Chemistry and Laboratory Medicine

Aims: To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles. Methods and Results: Extensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions...

Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses

ObjectiveOne of the important proteins involved in lipid metabolism is the ATP-binding cassette transporter A1 (ABCA1) encoding by ABCA1 gene. In this study we evaluated the single nucleotide polymorphisms (SNPs) of ABCA1 gene. We analyzed SNPs in chromosome 9 such as rs2230806 (R219K) in the position 107620867, rs2230808 (R1587K) in the position 106602625 and rs4149313 (I883M...

Platelet activating factor levels and metabolism in tangier disease: a case study

Marianna N Xanthopoulou Genovefa Kolovou 1 Constantinos A Demopoulos 0 0 Biochemistry Laboratory, Faculty of Chemistry, National and Kapodistrian University of Athens , Athens , Greece 1 Cardiology

Changes in Lipids and Lipoproteins after Selective LDL Apheresis (7-Year Experience)

Editor: Peter J. Lansberg Copyright © 2012 Genovefa Kolovou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution

ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses

Objective The ATP-binding cassette transporter A1 (ABCA1) is essential protein involved in lipid metabolism. The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808 (R1587K)] and lipid profile in Greek young nurses. Methods The study population consisted of 308 unrelated nurses who were genotyped and...

The role of common variants of the cholesteryl ester transfer protein gene in left main coronary artery disease

Background The cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis. Methods The DNA of 471 subjects [133 subjects with angiographically documented left main coronary artery disease (LMCAD), 241 subjects with more peripheral coronary artery disease (MPCAD) and 97 subjects self reported...

Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study

Peppes Panagiota Fili 0 Genovefa Kolovou Vassileios Papamikos 0 Dimitrios Richter Nikolaos Zakopoulos Kaarel Krjutkov Andres Metspalu George V Dedoussis 0 0 Harokopio University of Athens, Department of

Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study

Although plasma fibrinogen levels are related to cardiovascular risk, data regarding the role of fibrinogen genetic variation in myocardial infarction (MI) or coronary artery disease (CAD) etiology remain inconsistent. The purpose of the present study was to investigate the effect of fibrinogen A (FGA), fibrinogen B (FGB) and fibrinogen G (FGG) gene SNPs and haplotypes on...

Myocardial inflammation in Duchenne Muscular Dystrophy as a precipitating factor for heart failure: a prospective study

Background In patients with Duchenne Muscular Dystrophy (DMD), the absent or diminished dystrophin leads to progressive skeletal muscle and heart failure. We evaluated the role of myocardial inflammation as a precipitating factor in the development of heart failure in DMD. Methods 20 DMD patients (aged 15-18 yrs) and 20 age-matched healthy volunteers were studied and followed-up...

Myocardial inflammation in Duchenne Muscular Dystrophy as a precipitating factor for heart failure: a prospective study

In patients with Duchenne Muscular Dystrophy (DMD), the absent or diminished dystrophin leads to progressive skeletal muscle and heart failure. We evaluated the role of myocardial inflammation as a precipitating factor in the development of heart failure in DMD. 20 DMD patients (aged 15-18 yrs) and 20 age-matched healthy volunteers were studied and followed-up for 2 years...

Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts

. Jacques, Ingegerd Johansson, Yongmei Liu, Mark I. McCarthy, Kari North, Jorma Viikari, M. Carola Zillikens, Josée Dupuis, Albert Hofman, Genovefa Kolovou, Kenneth Mukamal, Inga Prokopenko, Olov Rolandsson ... Center, Athens, Greece (Genovefa Kolovou); Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts (Kenneth Mukamal); Unit of Family Medicine, Department

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as...

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052...