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11 papers found.
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Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma

notes These authors contributed equally: Yang W. Shao, Geoffrey A. Wood, Jinchang Lu. AffiliationsPrincess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, M5G 1L7, CanadaYang W. Shao ... AuthorsSearch for Yang W. Shao in:Nature Research journals • PubMed • Google Scholar Search for Geoffrey A. Wood in:Nature Research journals • PubMed • Google Scholar Search for Jinchang Lu in:Nature Research

Enhancing Immune Responses to Cancer Vaccines Using Multi-Site Injections

, Leonardo Susta, Geoffrey A. Wood, Sarah K. Wootton, Khalil Karimi & Byram W. BridleDepartment of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, CanadaAnthony ... James J. Petrik in:Nature Research journals • PubMed • Google Scholar Search for Geoffrey A. Wood in:Nature Research journals • PubMed • Google Scholar Search for Sarah K. Wootton in:Nature Research

A Case of Bilateral Auricular Chondritis in a Heifer

Auricular chondritis is an extremely rare condition in cattle and other domestic animals. A 13-month-old Jersey heifer was presented with cutaneous papillomatosis and bilaterally droopy ears. Histopathology revealed bilateral auricular chondritis characterized by lymphoplasmacytic infiltrate and extensive destruction and fibrosis of the auricular cartilage.

Timp3 Deficient Mice Show Resistance to Developing Breast Cancer

Timp3 is commonly silenced in breast cancer, but mechanistic studies have identified both tumor promotion and suppression effects of this gene. We have taken a genetic approach to determine the impact of Timp3 loss on two mouse models of breast cancer. Interestingly, MMTV-PyMT Timp3−⁄− mice have delayed tumor onset and 36% of MMTV-Neu Timp3−⁄− mice remain tumor free. TIMP3 is a...

The POZ-ZF Transcription Factor Kaiso (ZBTB33) Induces Inflammation and Progenitor Cell Differentiation in the Murine Intestine

Since its discovery, several studies have implicated the POZ-ZF protein Kaiso in both developmental and tumorigenic processes. However, most of the information regarding Kaiso’s function to date has been gleaned from studies in Xenopus laevis embryos and mammalian cultured cells. To examine Kaiso’s role in a relevant, mammalian organ-specific context, we generated and...

Inflammation and breast cancer. Metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer

Two rapidly evolving fields are converging to impact breast cancer: one has identified novel substrates of metalloproteinases that alter immune cell function, and the other has revealed a role for inflammation in human cancers. Evidence now shows that the mechanisms underlying these two fields interact in the context of breast cancer, providing new opportunities to understand...

Resistance of Copenhagen rats to hepatocarcinogenesis does not involve T-cell immunity

Previously, we have shown that Copenhagen (Cop) rats are highly resistant, compared with susceptible F344 rats, to the growth of glutathione S-transferase 7-7 (GST 7-7) positive preneoplastic liver lesions following treatment with a modified resistant hepatocyte (RH) protocol. Donryu rats, a strain with a level of susceptibility similar to F344, have a reduced T-cell response...

Cyclin D 1 expression during rat mammary tumor development and its potential role in the resistance of the Copenhagen rat

Background Resistance to mammary tumorigenesis in Copenhagen rats is associated with loss of early preneoplastic lesions known as intraductal proliferations. The cause of this disappearance, however, is unknown. Results There were no differences in the numbers of lesions in mammary whole-mounts prepared from Copenhagen or Wistar-Furth rats at 20 or 30 days after N-methyl-N...

Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats

Previously, we have shown that Copenhagen (Cop) rats are highly resistant to the induction of putative preneoplastic, glutathione S-transferase 7-7 (GST 7-7)-positive liver lesions following treatment with a modified resistant hepatocyte protocol. The objective of the current study was to establish the time course for the development of resistance and examine potential resistance...

Experimental manipulation of radiographic density in mouse mammary gland

Introduction Extensive mammographic density in women is associated with increased risk for breast cancer. Mouse models provide a powerful approach to the study of human diseases, but there is currently no model that is suited to the study of mammographic density. Methods We performed individual manipulations of the stromal, epithelial and matrix components of the mouse mammary...

A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia

Voronina 8 Igor Vukobradovic 8 Geoffrey A. Wood 8 Yonghong Zhu 4 Ralph A. Zirngibl 6 Jane E. Aubin 6 8 Donglin Bai 11 Benoit G. Bruneau 4 5 6 Marc Grynpas 2 8 Janet E. Henderson 3 R. Mark Henkelman 9 14