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56 papers found.
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Functioning and quality of life in patients with neuropathy associated with anti-MAG antibodies

Although anti-myelin-associated glycoprotein (MAG) antibody neuropathy is reported as a slowly progressive disease, it can lead to significant disability and impairment of health-related quality of life (HR-QoL) and social participation. The aim of this cross-sectional study was to evaluate the functioning and HR-QoL determinants in 67 patients with anti-MAG neuropathy in terms...

Benefit–Risk Profile of Sphingosine-1-Phosphate Receptor Modulators in Relapsing and Secondary Progressive Multiple Sclerosis

Novartis Pharma AG. Conflict of interest Giancarlo Comi has received consultancy fees and/or research support from Almirall, Bayer Schering Pharma, Biogen Dompe´, Celgene, Excemed, Forward Pharma, Genzyme

Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis

Microglia activation is a commonly pathological hallmark of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), a devastating disorder characterized by a selective motor neurons degeneration. Whether such activation might represent a causal event rather than a secondary epiphenomenon remains elusive. Here, we show that CNS-delivery of IL-4—via a lentiviral...

Correction to: Management of pregnancy-related issues in multiple sclerosis patients: the need for an interdisciplinary approach

The original version contained a mistake. The authors have specified only in a few paragraphs that all the contents of the paper are meant for Copaxone but not for unbranded glatiramer acetate, Authors ask to add the specification of Copaxone or branded glatiramer acetate everytime.

Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis

Mechelli Vittorio Martinelli Paul Hertzog Marco Salvetti Roberto Furlan Gianvito Martino Giancarlo Comi Eliana M. Coccia Cinthia Farina Recent evidence indicates that single multiple sclerosis (MS ... , Novartis and Roche, and research support from EMD Serono. Gianvito Martino received speaker honoraria from Biogen Idec, Merck Serono; travel and research support from Merck Serono, Teva. Giancarlo Comi

Free Light Chains and Intrathecal B Cells Activity in Multiple Sclerosis: A Prospective Study and Meta-Analysis

Colombo,2 Massimo Locatelli,1 Giancarlo Comi,2 Roberto Furlan,3 and Vittorio Martinelli2 1Department of Laboratory Medicine, San Raffaele Hospital, Milan, Italy 2Department of Neurology, San Raffaele

Cortical Motor Circuits after Piano Training in Adulthood: Neurophysiologic Evidence

The neuronal mechanisms involved in brain plasticity after skilled motor learning are not completely understood. We aimed to study the short-term effects of keyboard training in music-naive subjects on the motor/premotor cortex activity and interhemispheric interactions, using electroencephalography and transcranial magnetic stimulation (TMS). Twelve subjects (experimental group...

Efficacy of fingolimod and interferon beta-1b on cognitive, MRI, and clinical outcomes in relapsing–remitting multiple sclerosis: an 18-month, open-label, rater-blinded, randomised, multicentre study (the GOLDEN study)

Medical, Surgery Science and Advanced Technology, MS Center, University Hospital , Catania , Italy 3 Giancarlo Comi 4 Department of Neurology and Psychiatry, Multiple Sclerosis Centre, S. Andrea Hospital ... , Multiple Sclerosis Centre, Gallarate Hospital, Gallarate, Italy, (7) Giancarlo Comi and Francesca Sangalli for Maria Emma Rodegher (co-PI at the time of the study), Department of Neurology and Institute of

Treatment Challenges of a Primary Vertebral Artery Aneurysm Causing Recurrent Ischemic Strokes

 Roberto Chiesa,4 Enrico Rinaldi,4 Vittorio Martinelli,1 Giancarlo Comi,1 Marco Bacigaluppi,1,2 and Maria Sessa1 1Stroke Unit, Department of Neurology and Neurophysiology, San Raffaele Scientific Institute

Treatment Challenges of a Primary Vertebral Artery Aneurysm Causing Recurrent Ischemic Strokes

 Roberto Chiesa,4 Enrico Rinaldi,4 Vittorio Martinelli,1 Giancarlo Comi,1 Marco Bacigaluppi,1,2 and Maria Sessa1 1Stroke Unit, Department of Neurology and Neurophysiology, San Raffaele Scientific Institute

The Communication of Multiple Sclerosis Diagnosis: The Patients’ Perspective

received personal compensation for activities with Biogen Dompe, Merck Serono, Bayer Schering, Teva, and Sanofi Aventis as a speaker. Giancarlo Comi has received compensation for consulting services and/or

The Communication of Multiple Sclerosis Diagnosis: The Patients’ Perspective

received personal compensation for activities with Biogen Dompe, Merck Serono, Bayer Schering, Teva, and Sanofi Aventis as a speaker. Giancarlo Comi has received compensation for consulting services and/or

Motor Cortical Plasticity to Training Started in Childhood: The Example of Piano Players

Converging evidence suggest that motor training is associated with early and late changes of the cortical motor system. Transcranial magnetic stimulation (TMS) offers the possibility to study plastic rearrangements of the motor system in physiological and pathological conditions. We used TMS to characterize long-term changes in upper limb motor cortical representation and...

Ceruloplasmin functional changes in Parkinson’s disease-cerebrospinal fluid

Background Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported in Parkinson’s disease (PD) contributing to the pathological iron accumulation. We previously showed that ceruloplasmin is modified by oxidation in vivo, and, in addition, in vitro by...

Incidence and course of depression in multiple sclerosis in the multinational BEYOND trial

Early experience in MS generated concerns that interferon beta treatment might provoke onset or worsening of depression. The objective of the study was to compare depression incidence in relapsing–remitting MS patients receiving interferon beta-1b (IFNB-1b) or glatiramer acetate (GA) in the BEYOND trial. 891/897 (99 %) of English, French, Spanish and Italian speakers among 2244...

Refractory migraine: the role of the physician in assessment and treatment of a problematic disease

Bruno Colombo Dacia Dalla Libera Gloria Dalla Costa Giancarlo Comi Patients affected by chronic forms of headache are often very difficult to treat. Refractory patients are so defined when adequate