Advanced search    

Search: authors:"Giorgio Sesti"

45 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation

, Jacques Mercier, Ramon Gomis, Serghey Litvinov, Elza Khusnutdinova, Catalina Poiana, Renato Pasquali, Davide Lauro, Giorgio Sesti, Sabrina Prudente, Vincenzo Trischitta, Agathocles Tsatsoulis, Agron Ylli ... , Renato Pasquali, Davide Lauro, Giorgio Sesti, Vincenzo Trischitta, Agathocles Tsatsoulis, Sonia Abdelhak, Abdelhamid Barakat, Akila Zenati, Agron Ylli, Ilhan Satman, Sasa Missoni. Software: Yannick Cogne

Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals

: Giorgio Sesti. Formal analysis: Francesco Andreozzi, Gaia Chiara Mannino. Funding acquisition: Gaia Chiara Mannino, Giorgio Sesti. Investigation: Elettra Mancuso, Rosangela Spiga. Writing ± original ... draft: Francesco Andreozzi, Gaia Chiara Mannino. Writing ± review & editing: Francesco Perticone, Giorgio Sesti. 8 / 9 1. Lee JH and Welch DR . Identification of highly expressed genes in metastasis

Association between hemoglobin glycation index with insulin resistance and carotid atherosclerosis in non-diabetic individuals

Hemoglobin glycation index (HGI), defined as the difference between the observed HbA1c value and the value of HbA1c predicted from plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with micro- and macro-vascular complications in subjects with type 2 diabetes. To investigate the...

Continued efforts to translate diabetes cardiovascular outcome trials into clinical practice

Diabetic patients suffer from a high rate of cardiovascular events and such risk increases with HbA1c. However, lowering HbA1c does not appear to yield the same benefit on macrovascular endpoints, as observed for microvascular endpoints. As the number of glucose-lowering medications increases, clinicians have to consider several open questions in the management of type 2 diabetes...

Efficacy and safety of dapagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in diabetes mellitus

Although antidiabetic agents have been developed to target one or more of the core defects of type 2 diabetes mellitus (T2DM), many patients do not achieve glycemic goals. Inhibition of the sodium-glucose cotransporter 2 (SGLT2) induces glycosuria, reduces glucose toxicity and improves insulin sensitivity and β-cell function. As the mechanism of action of SGLT2 inhibitors is...

The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism

Aims/hypothesis Potentiation of glucose-induced insulin secretion is the main mechanism of exenatide (EXE) antidiabetic action, however, increased glucose utilization by peripheral tissues has been also reported. We here studied the effect of EXE on glucose uptake by skeletal muscle cells. Methods 2-deoxy-glucose (2DG) uptake and intracellular signal pathways were measured in rat...

Glycemic Control Impact on Body Weight Potential to Reduce Cardiovascular Risk: Glucagon-like peptide 1 agonists

GIORGIO SESTI - T 2 diabetes are progressively increashe prevalence and incidence of type ing because of a concomitant rise in the prevalence of obesity. Intentional weight loss in patients with

Association between Noninvasive Fibrosis Markers and Cardio-Vascular Organ Damage among Adults with Hepatic Steatosis

. Competing Interests: Giorgio Sesti is a PLOS ONE Editorial Board member. This does not alter the authors adherence to PLOS ONE Editorial policies and criteria. Nonalcoholic fatty liver disease (NAFLD) is the

Association between Noninvasive Fibrosis Markers and Chronic Kidney Disease among Adults with Nonalcoholic Fatty Liver Disease

from other known factors. - Funding: This work was supported by Italian Ministry of University grant FIRB/MERIT RBNE08NKH7_002 to Giorgio Sesti. The funder had no role in study design, data collection ... and analysis, decision to publish, or preparation of the manuscript. Competing Interests: Giorgio Sesti is a member of the PLOS ONE Editorial Board, but this does not alter the authors adherence to all

Low dose of acetylsalicylic acid and oxidative stress-mediated endothelial dysfunction in diabetes: a short-term evaluation

, Vincenzo Mollace, Giorgio Sesti and Francesco Perticone declare that they have no conflict of interest. Human and animal rights All procedures followed were in accordance with the ethical standards of the

Association of Insulin Resistance Indexes to Carotid Intima–Media Thickness

Objectives Accumulating evidence suggests an association between insulin resistance (IR) and cardiovascular diseases The aim of this study was to examine the relationship between indexes of IR and common carotid intima–media thickness (IMT), an indicator of vascular damage. Methods In 847 non-diabetic Caucasians a 75 g oral glucose tolerance test was performed and surrogate...

A Fasting Insulin–Raising Allele at IGF1 Locus Is Associated with Circulating Levels of IGF-1 and Insulin Sensitivity

) to Giorgio Sesti. No additional external funding was received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the

Vitamin D and 1-hour post-load plasma glucose in hypertensive patients

Background A plasma glucose value ≥155 mg/dl for 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify subjects with normal glucose tolerance (NGT) at high-risk for type-2 diabetes and with subclinical organ damage. We designed this study to address if 25-hydroxyvitamin D [25(OH)D] circulating levels are associated with glucose tolerance...

Hypoglycemia Assessed by Continuous Glucose Monitoring Is Associated with Preclinical Atherosclerosis in Individuals with Impaired Glucose Tolerance

Hypoglycemia is associated with increased risk of cardiovascular adverse clinical outcomes. There is evidence that impaired glucose tolerance (IGT) is associated with cardiovascular morbidity and mortality. Whether IGT individuals have asymptomatic hypoglycemia under real-life conditions that are related to early atherosclerosis is unknown. To this aim, we measured episodes of...

Decreased Insulin Clearance in Individuals with Elevated 1-h Post-Load Plasma Glucose Levels

preparation of the manuscript. Competing Interests: Co-authors Giorgio Sesti and Marta Letizia Hribal serve as Editorial Board Members in PLOS ONE; they declare that this does not alter their adherence to all

Effects of Weight Loss in Metabolically Healthy Obese Subjects after Laparoscopic Adjustable Gastric Banding and Hypocaloric Diet

Weight loss in metabolically healthy obese (MHO) subjects may result in deterioration of cardio-metabolic risk profile. We analyzed the effects of weight loss induced by laparoscopic adjustable gastric banding (LAGB) on cardio-metabolic risk factors in MHO and insulin resistant obese (IRO) individuals. This study included 190 morbidly obese non-diabetic subjects. Obese...

Serum Uric Acid and 1-h Postload Glucose in Essential Hypertension

FRANCESCO PERTICONE ANGELA SCIACQUA MARIA PERTICONE FRANCO ARTURI PAOLA ELISA SCARPINO MICHELE QUERO GIORGIO SESTI C a r d i o v a s c u l a r a n d OBJECTIVEdSubjects who are normal glucose

Association between One-Hour Post-Load Plasma Glucose Levels and Vascular Stiffness in Essential Hypertension

Franco Arturi 0 Giorgio Sesti 0 Francesco Perticone 0 Melania Manco, Scientific Directorate, Bambino Hospital, Italy 0 Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro ... stiffness. Conclusion: Hypertensive NGT$155 subjects, compared with NGT,155, have higher PWV and its hemodynamic correlates that increase their cardiovascular risk profile. - Competing Interests: Giorgio

One-Hour Postload Plasma Glucose Levels and Left Ventricular Mass in Hypertensive Patients

ANGELA SCIACQUA SOFIA MICELI GIUSEPPE CARULLO LAURA GRECO ELENA SUCCURRO FRANCO ARTURI GIORGIO SESTI FRANCESCO PERTICONE C a r d i o v a s c u l a r OBJECTIVE-Left ventricular hypertrophy (LVH), an