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11 papers found.
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Evidence that a primary anti-viral stimulation of the immune response by OM-85 reduces susceptibility to a secondary respiratory bacterial infection in mice

Viral respiratory infections may promote bacterial super-infection decreasing the host immune response efficiency. However, using a mice model we recently demonstrated that preventive treatment with the bacterial extract OM-85 reduces the susceptibility to a secondary Streptococcus (S.) pneumoniae infection after influenza virus (I.V.) challenge. To better characterize the...

Melatonin: its possible role in the management of viral infections-a brief review

Melatonin, a versatile molecule, is synthesized by the pineal gland but also by other organs, including gastrointestinal tract, retina, thymus, bone marrow, and by leukocytes. Besides playing an important role in various functions of the body, including sleep and circadian rhythm regulation, melatonin also shows immunoregulatory, free radical scavenger and antioxidant functions...

Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression

Sonia Carta 0 Michela Silvestri 0 Giovanni A Rossi 0 0 Pediatric Allergy and Pulmonary Disease Unit, Istituto Giannina Gaslini , Via G Gaslini 5, 16147, Genoa , Italy Background: Recurrent

Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression

Recurrent respiratory infections are one of the most important causes of morbidity in childhood. When immune functions are still largely immature, the airway epithelium plays a primary defensive role since, besides providing a physical barrier, it is also involved in the innate and the adaptive immune responses. A study was therefore designed to evaluate in vitro whether...

Type III pleuropulmonary blastoma in a 7-month-old female baby with impending respiratory failure: a case report

Introduction Pleuropulmonary blastoma is a very rare, aggressive, embryonal pulmonary neoplasm which mostly affects children under the age of 5. According to the histopathological features, three subtypes of pleuropulmonary blastoma have been recognized: type I (purely cystic), type II (grossly visible cystic and solid elements) and type III (purely solid). Characteristics of...

Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway

A Rossi 0 0 Pulmonary Disease Unit, G. Gaslini Institute , Genoa , Italy 1 Institute of Biophysics, National Research Council , Genoa , Italy 2 Laboratorio di Genetica Molecolare G. Gaslini Institute

Short term efficacy of nebulized beclomethasone in mild-to-moderate wheezing episodes in pre-school children

Background Few data are available on the usefulness of short term treatment with low-medium dose of inhaled corticosteroids (ICS) in pre-school children with wheezing exacerbations. Methods To compare the efficacy of one week treatment with 400 μg b.i.d. nebulized beclomethasone dipropionate (BDP), plus nebulized 2500 μg prn salbutamol (BDP group), versus nebulized b.i.d. placebo...

Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants

Giovanni A Rossi 1 15 Silvia Vandini 12 Alessandro Rimini 20 Costantino Romagnoli 12 Pierluigi Colonna 20 Andrea Biondi 19 Paolo Biban 18 Giampietro Chiamenti 17 Roberto Bernardini 22 Marina Picca 21 Marco

Risk factors for severe RSV-induced lower respiratory tract infection over four consecutive epidemics

Variability in severity among different respiratory syncytial virus (RSV) seasons may influence hospital admission rates for RSV-induced lower respiratory tract infection (LRTI) in young children. The aim of the present study was to identify through logistic regression analysis, risk factors associated with higher likelihood to acquire RSV-induced LRTI, in children with symptoms...