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7 papers found.
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The potential role of the osteopontin–osteocalcin–osteoprotegerin triad in the pathogenesis of prediabetes in humans

Aims To examine the relationship between hormones involved in bone remodeling and glucose metabolism alterations in prediabetes. Methods Individuals (n = 43) with NGT (BMI = 31.1 ± 1.1 kg/m2) and individuals (n = 79) with impaired glucose regulation (IGR) (BMI = 31.9 ± 1.2 kg/m2) including subjects with IFG, IGT, and IFG-IGT underwent OGTT and DXA. Osteopontin (OPN), osteocalcin...

Metabolic regulation of GLP-1 and PC1/3 in pancreatic α-cell line

glucose control; $p<0.05 compare to 16.7mM glucose control. (TIFF) Author Contributions Conceptualization: Veronica Sancho, Stefano Del Prato. Formal analysis: Veronica Sancho, Giuseppe Daniele. 10 / 12 ... Sancho. Writing ± review & editing: Giuseppe Daniele, Annamaria Ciccarone, Giuseppe Penno, Cristina Bianchi, Angela Dardano, Roberto Miccoli, Stefano Del Prato. 11 / 12 1. Baggio LL and Drucker DJ

Evidence for two distinct phenotypes of chronic kidney disease in individuals with type 1 diabetes mellitus

Aims/hypothesisIn a retrospective, observational, cross-sectional, single-centre study, we assessed the prevalence and correlates of different CKD phenotypes (with and without albuminuria) in a large cohort of patients of white ethnicity with type 1 diabetes.MethodsFrom 2001 to 2009, 408 men and 369 women with type 1 diabetes (age 40.2 ± 11.7 years, diabetes duration 19.4 ± 12.2...

Acid-Base Chemistry of White Wine: Analytical Characterisation and Chemical Modelling

A chemical model of the acid-base properties is optimized for each white wine under study, together with the calculation of their ionic strength, taking into account the contributions of all significant ionic species (strong electrolytes and weak one sensitive to the chemical equilibria). Coupling the HPLC-IEC and HPLC-RP methods, we are able to quantify up to 12 carboxylic acids...

Is There Evidence That Oral Hypoglycemic Agents Reduce Cardiovascular Morbidity/Mortality? Yes

CRISTINA BIANCHI 0 ROBERTO MICCOLI 0 GIUSEPPE DANIELE 0 0 From the Department of Endocrinology and Metabolism, Section of Diabetes and Metabolic Diseases, University of Pisa , Pisa , Italy - A

Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3–TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study

Aims/hypothesisPioglitazone (PIO) is a peroxisome proliferator-activated receptor (PPAR)γ agonist insulin-sensitiser with anti-inflammatory and anti-atherosclerotic effects. Our objective was to evaluate the effect of low-dose PIO (15 mg/day) on glucose metabolism and inflammatory state in obese individuals with type 2 diabetes.MethodsA randomised, double-blind, placebo...