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High prevalence and diversity of HIV-1 non-B genetic forms due to immigration in southern Spain: A phylogeographic approach

the HIV-1 pol sequences in each dataset included in this study. Author Contributions Conceptualization: Santiago PeÂrez-Parra, Natalia Chueca, Marta AÂ lvarez, Gonzalo Yebra. Data curation: Santiago ... GarcÂõa. Investigation: Santiago PeÂrez-Parra, Natalia Chueca, Marta AÂ lvarez, Federico GarcÂõa. Methodology: Santiago PeÂrez-Parra, Natalia Chueca, Gonzalo Yebra, Federico GarcÂõa. Project

A high HIV-1 strain variability in London, UK, revealed by full-genome analysis: Results from the ICONIC project

foundation Trust) and Prof A.J. Leigh Brown (University of Edinburgh). Author Contributions Conceptualization: Gonzalo Yebra, Dan Frampton, Zisis Kozlakidis, Andrew Hayward, Paul Kellam, Andrew J. Leigh ... , Jonathan Hubb, R. Bridget Ferns, Laura Waters, C. Y. William Tong, Zisis Kozlakidis, Andrew Hayward, Paul Kellam, Deenan Pillay, Duncan Clark, Eleni Writing ± original draft: Gonzalo Yebra, Andrew J. Leigh

Phylodynamic and Phylogeographic Profiles of Subtype B HIV-1 Epidemics in South Spain

Background Since 1982, HIV-1 epidemics have evolved to different scenarios in terms of transmission routes, subtype distribution and characteristics of transmission clusters. We investigated the evolutionary history of HIV-1 subtype B in south Spain. Patients & Methods We studied all newly diagnosed HIV-1 subtype B patients in East Andalusia during the 2005–2012 period. For the...

Description of HIV-1 Group M Molecular Epidemiology and Drug Resistance Prevalence in Equatorial Guinea from Migrants in Spain

Background The HIV epidemic is increasing in Equatorial Guinea (GQ), West Central Africa, but few studies have reported its HIV molecular epidemiology. We aimed to describe the HIV-1 group M (HIV-1M) variants and drug-resistance mutations in GQ using sequences sampled in this country and in Spain, a frequent destination of Equatoguinean migrants. Methods We collected 195 HIV-1M...

Increase of Transmitted Drug Resistance among HIV-Infected Sub-Saharan Africans Residing in Spain in Contrast to the Native Population

Background The prevalence of transmitted HIV drug resistance (TDR) is stabilizing or decreasing in developed countries. However, this trend is not specifically evaluated among immigrants from regions without well-implemented antiretroviral strategies. Methods TDR trends during 1996–2010 were analyzed among naïve HIV-infected patients in Spain, considering their origin and other...

High Drug Resistance Prevalence among Vertically HIV-Infected Patients Transferred from Pediatric Care to Adult Units in Spain

Background Antiretroviral treatment (ART) has contributed to increased life expectancy of HIV-1 infected children. In developed countries, an increasing number of children reaching adulthood are transferred to adult units. The objectives were to describe the demographic and clinical features, ART history, antiviral drug resistance and drug susceptibility in HIV-1 perinatally...

Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis

Background Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance testing is not affordable. We sought to understand the molecular epidemiology of TDR and to identify the HIV-1...