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Search: authors:"Gopal Peddinti"

3 papers found.
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Diacetyl control during brewery fermentation via adaptive laboratory engineering of the lager yeast Saccharomyces pastorianus

Diacetyl contributes to the flavor profile of many fermented products. Its typical buttery flavor is considered as an off flavor in lager-style beers, and its removal has a major impact on time and energy expenditure in breweries. Here, we investigated the possibility of lowering beer diacetyl levels through evolutionary engineering of lager yeast for altered synthesis of...

Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

Background Genome-wide loss-of-function profiling is widely used for systematic identification of genetic dependencies in cancer cells; however, the poor reproducibility of RNA interference (RNAi) screens has been a major concern due to frequent off-target effects. Currently, a detailed understanding of the key factors contributing to the sub-optimal consistency is still a...

Early metabolic markers identify potential targets for the prevention of type 2 diabetes

Partnership for Molecular Medicine, University of Helsinki , Helsinki , Finland 4 Gopal Peddinti 5 Lund University Diabetes Center , Lund , Sweden 6 Department of Genomics of Common Disease, School of Public