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Successful five-item triage for the broad spectrum of mental disorders in pregnancy – a validation study

Background Mental disorders are prevalent during pregnancy, affecting 10% of women worldwide. To improve triage of a broad spectrum of mental disorders, we investigated the decision impact validity of: 1) a short set of currently used psychiatric triage items, 2) this set with the inclusion of some more specific psychiatric items (intermediate set), 3) this new set with the...

Validity of a questionnaire measuring the world health organization concept of health system responsiveness with respect to perinatal services in the dutch obstetric care system

Background The concept of responsiveness, introduced by the World Health Organization (WHO), addresses non-clinical aspects of health service quality that are relevant regardless of provider, country, health system or health condition. Responsiveness refers to “aspects related to the way individuals are treated and the environment in which they are treated” during health system...

Effectiveness of score card-based antenatal risk selection, care pathways, and multidisciplinary consultation in the Healthy Pregnancy 4 All study (HP4ALL): study protocol for a cluster randomized controlled trial

Background Promotion of healthy pregnancies has gained high priority in the Netherlands because of relatively unfavorable perinatal outcomes. In response, a nationwide study, ‘Healthy Pregnancy 4 All’ (HP4ALL), has been initiated. Part of this study involves systematic and broadened antenatal risk assessment (the Risk Assessment substudy). Risk selection in current clinical...

Regional differences in severe postpartum hemorrhage: a nationwide comparative study of 1.6 million deliveries

Altenstadt Chantal WPM Hukkelhoven Gouke J Bonsel 0 Eric AP Steegers 0 Ben W Mol Joke M Schutte Kitty WM Bloemenkamp Johannes J Duvekot 0 0 Department of Obstetrics and Gynecology, Division of Obstetrics

Obstetrical outcome valuations by patients, professionals, and laypersons: differences within and between groups using three valuation methods

Background Decision-making can be based on treatment preferences of the patient, the doctor, or by guidelines based on lay people's preferences. We compared valuations assigned by three groups: patients, obstetrical care professionals, and laypersons, for health states involving both mother and (unborn) child. Our aim was to compare the valuations of different groups using...

Design and outline of the Healthy Pregnancy 4 All study

Background Promotion of healthy pregnancies has gained high priority in the Netherlands because of the relatively unfavourable perinatal health outcomes. In response a nationwide study Healthy Pregnancy 4 All was initiated. This study combines public health and epidemiologic research to evaluate the effectiveness of two obstetric interventions before and during pregnancy: (1...

Posttraumatic stress symptoms and health-related quality of life: a two year follow up study of injury treated at the emergency department

Background Among injury victims relatively high prevalence rates of posttraumatic stress disorder (PTSD) have been found. PTSD is associated with functional impairments and decreased health-related quality of life (HRQoL). Previous studies that addressed the latter were restricted to injuries at the higher end of the severity spectrum. This study examined the association between...

When outcome is a balance: methods to measure combined utility for the choice between induction of labour and expectant management in mild risk pregnancy at term

Background When the primary and secondary outcomes of clinical studies yield ambiguous or conflicting recommendations, preference or valuation studies may help to overcome the decision problem. The present preference study is attached to two clinical studies (DIGTAT, ISRCT10363217; HYPITAT, ISRCT08132825) that evaluate induction of labour versus expectant management in term...

Individual differences in the use of the response scale determine valuations of hypothetical health states: an empirical study

Background The effects of socio-demographic characteristics of the respondent, including age, on valuation scores of hypothetical health states remain inconclusive. Therefore, we analyzed data from a study designed to discriminate between the effects of respondents' age and time preference on valuations of health states to gain insight in the contribution of individual response...

Regional perinatal mortality differences in the Netherlands; care is the question

Greta C Rijninks-van Driel 4 Gouke J Bonsel 3 Anita CJ Ravelli 2 0 Department of Obstetrics and Gynaecology, University Medical Center Groningen , Groningen , the Netherlands 1 Department of Clinical

Long term costs and effects of reducing the number of twin pregnancies in IVF by single embryo transfer: the TwinSing study

Mirjam MJ van Heesch 0 Gouke J Bonsel John CM Dumoulin Johannes LH Evers Mark AHBM van der Hoeven Johan L Severens Ramon HM Dykgraaf Fulco van der Veen Nino Tonch Willianne LDM Nelen Piet van

Multiplex ligation-dependent probe amplification versus karyotyping in prenatal diagnosis: the M.A.K.E. study

Background In the past 30 years karyotyping was the gold standard for prenatal diagnosis of chromosomal aberrations in the fetus. Traditional karyotyping (TKT) has a high accuracy and reliability. However, it is labor intensive, the results take 14–21 days, the costs are high and unwanted findings such as abnormalities with unknown clinical relevance are not uncommon. These...