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30 papers found.
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Multiplex ligation-dependent probe amplification versus karyotyping in prenatal diagnosis: the M.A.K.E. study

Background In the past 30 years karyotyping was the gold standard for prenatal diagnosis of chromosomal aberrations in the fetus. Traditional karyotyping (TKT) has a high accuracy and reliability. However, it is labor intensive, the results take 14–21 days, the costs are high and unwanted findings such as abnormalities with unknown clinical relevance are not uncommon. These...

362 Assessing performance of paediatric intensive care

Performance of a 10 bed paediatric intensive care unit (PICU) in a university children's hospital was assessed in a prospective cohort study of unselected, consequtive admissions. Collected data included primary clinical specialty, PRISM score derived mortality risk, administration of PICU-dependent therapy and vital status at discharge. Effectiveness of care was determined by...

Additive or Sequential Nucleoside Analogue Therapy Compared with Continued Zidovudine Monotherapy in Human Immunodeficiency Virus-Infected Patients with Advanced Disease Does Not Prolong Survival: An Observational Study

To study the effect of sequential or additive use of zalcitabine or didanosine on survival in 308 human immunodeficiency virus-infected patients with advanced disease treated with zidovudine, an observational study using time-dependent Cox proportional hazards models was done. Changing to sequential or additive therapy was based on deterioration of a patient's health status, a...

Long term costs and effects of reducing the number of twin pregnancies in IVF by single embryo transfer: the TwinSing study

Mirjam MJ van Heesch 0 Gouke J Bonsel John CM Dumoulin Johannes LH Evers Mark AHBM van der Hoeven Johan L Severens Ramon HM Dykgraaf Fulco van der Veen Nino Tonch Willianne LDM Nelen Piet van

Expectant management versus surgical evacuation in first trimester miscarriage: health-related quality of life in randomized and non-randomized patients

BACKGROUND: Expectant management, although less effective, is an alternative treatment option for surgical evacuation in women with a miscarriage. We assessed health-related quality of life (HRQL) differences over time between expectant and surgical management in women with a miscarriage. METHODS: Women with a miscarriage were randomized to either expectant (n = 64) or surgical...

Maternal health-related quality of life after induction of labor or expectant monitoring in pregnancy complicated by intrauterine growth retardation beyond 36 weeks

Objective Pregnancies complicated by intrauterine growth retardation (IUGR) beyond 36 weeks of gestation are at increased risk of neonatal morbidity and mortality. Optimal treatment in IUGR at term is highly debated. Results from the multicenter DIGITAT (Disproportionate Intrauterine Growth Intervention Trial At Term) trial show that induction of labor and expectant monitoring...

Management of miscarriage: a randomized controlled trial of expectant management versus surgical evacuation

BACKGROUND: In many countries, surgical uterine evacuation is the standard treatment for women with a miscarriage, but expectant management has been advocated as an alternative. The choice between the two options cannot be based on published evidence alone, because randomized clinical trials are scarce while generalizability of findings to patients with a strong preference for...

Individual accumulation of heterogeneous risks explains perinatal inequalities within deprived neighbourhoods

Dutch’ figures on perinatal mortality and morbidity are poor compared to EU-standards. Considerable within-country differences have been reported too, with decreased perinatal health in deprived urban areas. We investigated associations between perinatal risk factors and adverse perinatal outcomes in 7,359 pregnant women participating in population-based prospective cohort study...

Regional perinatal mortality differences in the Netherlands; care is the question

Greta C Rijninks-van Driel 4 Gouke J Bonsel 3 Anita CJ Ravelli 2 0 Department of Obstetrics and Gynaecology, University Medical Center Groningen , Groningen , the Netherlands 1 Department of Clinical

Individual differences in the use of the response scale determine valuations of hypothetical health states: an empirical study

Background The effects of socio-demographic characteristics of the respondent, including age, on valuation scores of hypothetical health states remain inconclusive. Therefore, we analyzed data from a study designed to discriminate between the effects of respondents' age and time preference on valuations of health states to gain insight in the contribution of individual response...

Obtaining insurance after DNA diagnostics: a survey among hypertrophic cardiomyopathy mutation carriers

Birnie Gouke J Bonsel Arthur AM Wilde Ellen MA Smets Hypertrophic cardiomyopathy (HCM) is a common hereditary heart disease associated with increased mortality. Disclosure of DNA test results may have

Uptake of genetic counselling and predictive DNA testing in hypertrophic cardiomyopathy

• Google ScholarSearch for Gouke J Bonsel in:Nature Research journals • PubMed • Google ScholarSearch for Arthur A M Wilde in:Nature Research journals • PubMed • Google ScholarSearch for Irene M van Langen

When outcome is a balance: methods to measure combined utility for the choice between induction of labour and expectant management in mild risk pregnancy at term

Background When the primary and secondary outcomes of clinical studies yield ambiguous or conflicting recommendations, preference or valuation studies may help to overcome the decision problem. The present preference study is attached to two clinical studies (DIGTAT, ISRCT10363217; HYPITAT, ISRCT08132825) that evaluate induction of labour versus expectant management in term...

Evaluating the discriminatory power of EQ-5D, HUI2 and HUI3 in a US general population survey using Shannon’s indices

Mathieu F. (Bas) Janssen 0 Erwin Birnie 0 Gouke J. Bonsel 0 0 M. F. (Bas) Janssen (&) E. Birnie G. J. Bonsel Public Health Epidemiology, Department of Social Medicine, Academic Medical Center

Posttraumatic stress symptoms and health-related quality of life: a two year follow up study of injury treated at the emergency department

Background Among injury victims relatively high prevalence rates of posttraumatic stress disorder (PTSD) have been found. PTSD is associated with functional impairments and decreased health-related quality of life (HRQoL). Previous studies that addressed the latter were restricted to injuries at the higher end of the severity spectrum. This study examined the association between...

Design and outline of the Healthy Pregnancy 4 All study

Background Promotion of healthy pregnancies has gained high priority in the Netherlands because of the relatively unfavourable perinatal health outcomes. In response a nationwide study Healthy Pregnancy 4 All was initiated. This study combines public health and epidemiologic research to evaluate the effectiveness of two obstetric interventions before and during pregnancy: (1...

Contribution of Primary Pelvic Organ Prolapse to Micturition and Defecation Symptoms

Objective. To investigate the contribution of Pelvic Organ Prolapse (POP) to micturition and defecation symptoms. Method. Cross-sectional study including 64 women presenting with POP symptoms and 50 controls without POP complaints. Subjects were evaluated using POP-Quantification system, Urinary Distress Inventory, and Defecation Distress Inventory. The MOS SF-36 health survey...

Obstetrical outcome valuations by patients, professionals, and laypersons: differences within and between groups using three valuation methods

Background Decision-making can be based on treatment preferences of the patient, the doctor, or by guidelines based on lay people's preferences. We compared valuations assigned by three groups: patients, obstetrical care professionals, and laypersons, for health states involving both mother and (unborn) child. Our aim was to compare the valuations of different groups using...

Regional differences in severe postpartum hemorrhage: a nationwide comparative study of 1.6 million deliveries

Altenstadt Chantal WPM Hukkelhoven Gouke J Bonsel 0 Eric AP Steegers 0 Ben W Mol Joke M Schutte Kitty WM Bloemenkamp Johannes J Duvekot 0 0 Department of Obstetrics and Gynecology, Division of Obstetrics

Effectiveness of score card-based antenatal risk selection, care pathways, and multidisciplinary consultation in the Healthy Pregnancy 4 All study (HP4ALL): study protocol for a cluster randomized controlled trial

Background Promotion of healthy pregnancies has gained high priority in the Netherlands because of relatively unfavorable perinatal outcomes. In response, a nationwide study, ‘Healthy Pregnancy 4 All’ (HP4ALL), has been initiated. Part of this study involves systematic and broadened antenatal risk assessment (the Risk Assessment substudy). Risk selection in current clinical...