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Identification of a T1D Susceptibility Gene

It is not known what causes type 1 diabetes (T1D), which affects over 1 million people in the U.S. alone. Each year, 30,000 young people in the U.S. develop this disease and depend on insulin injections thereafter. Because of the huge cost to the individual, the family, and to society in increased health care costs, it is important to find what makes these people susceptible. The...

Analysis of early mesothelial cell responses to Staphylococcus epidermidis isolated from patients with peritoneal dialysis-associated peritonitis

The major complication of peritoneal dialysis (PD) is the development of peritonitis, an infection within the abdominal cavity, primarily caused by bacteria. PD peritonitis is associated with significant morbidity, mortality and health care costs. Staphylococcus epidermidis is the most frequently isolated cause of PD-associated peritonitis. Mesothelial cells are integral to the...

Transcriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1–5-HT axis

Morahan 2 Leonard C. Harrison 3 0 Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan , Ann Arbor, MI 48109 , USA 1 Present address: Southern Cross Plant Science

Comparison of sequence variants in transcriptomic control regions across 17 mouse genomes

The laboratory mouse is the most widely used mammalian model organism in biomedical research, so a thorough annotation of functional variation in the mouse genome would be of significant value. In this study, we compared sequence variation in a comprehensive list of functional elements (e.g. promoters, enhancers and CTCF binding sites) across 17 inbred mouse strains. Sequences...

Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Krishnamurthy, Christian M Nefzger, Laurence Macia, Alison Thorburn, Alan G Baxter, Grant Morahan, Lee H Wong, Jose M Polo, Robert J Moore, Trevor J Lockett, Julie M Clarke, David L Topping , Leonard C Harrison

Definition of High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Types Using Only Three Single Nucleotide Polymorphisms

Cao Nguyen Michael D. Varney Leonard C. Harrison Grant Morahan Evaluating risk of developing type 1 diabetes (T1D) depends on determining an individual's HLA type, especially of the HLA DRB1 and

The Affymetrix DMET Plus Platform Reveals Unique Distribution of ADME-Related Variants in Ethnic Arabs

 Batoul Baz,1 Asma I. Tahir,1 Brian F. Meyer,1 Grant Morahan,2 and Nduna Dzimiri1 1King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia 2The University of Western Australia

A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8

BackgroundNephronophthisis (NPHP) as a cause of cystic kidney disease is the most common genetic cause of progressive renal failure in children and young adults. NPHP is characterized by abnormal and/or loss of function of proteins associated with primary cilia. Previously, we characterized an autosomal recessive phenotype of cystic kidney disease in the Lewis Polycystic Kidney...

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

Balasubramanian Krishnamurthy Jonathan Chee Gaurang Jhala Stacey Fynch Kate L. Graham Pere Santamaria Grant Morahan Janette Allison David Izon Helen E. Thomas Thomas W.H. Kay Prevention of

Status and access to the Collaborative Cross population

The Collaborative Cross (CC) is a panel of recombinant inbred lines derived from eight genetically diverse laboratory inbred strains. Recently, the genetic architecture of the CC population was reported based on the genotype of a single male per line, and other publications reported incompletely inbred CC mice that have been used to map a variety of traits. The three breeding...

Genetics of Type 1 Diabetes: What's Next?

Flemming Pociot Beena Akolkar Patrick Concannon Henry A. Erlich Ce cile Julier Grant Morahan Concepcion R. Nierras John A. Todd Stephen S. Rich Jrn Nerup Tthe major histocompatibility complex (MHC

A Susceptibility Allele From a Non-Diabetes-Prone Mouse Strain Accelerates Diabetes in NOD Congenic Mice

Thomas C. Brodnicki Fiona Quirk Grant Morahan The nonobese diabetic (NOD) mouse is genetically predisposed for the spontaneous development of type 1 diabetes. Linkage analyses have identified at

The clinical course of steroid-sensitive childhood nephrotic syndrome is associated with a functional IL12B promoter polymorphism

Background. Steroid-sensitive nephrotic syndrome (NS) of childhood is the most common glomerular disease in children. The type and duration of response to corticosteroid therapy are used for clinical classification, and especially patients with steroid dependence often have a complicated course, requiring intensified immunosuppressive treatment. Its cause is still unknown...

The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower-Risk Human Leukocyte Antigen Genotypes

SPIROS FOURLANOS FRACP PHD MICHAEL D. VARNEY PHD BRIAN D. TAIT PHD GRANT MORAHAN PHD MARGO C. HONEYMAN PHD PETER G. COLMAN FRACP LEONARD C. HARRISON FRACP FRCPA DSC OBJECTIVE - The rising incidence

Tests for Genetic Interactions in Type 1 Diabetes: Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs

Grant Morahan Munish Mehta Ian James Wei-Min Chen Beena Akolkar Henry A. Erlich Joan E. Hilner Ccile Julier Jrn Nerup Concepcion Nierras Flemming Pociot John A. Todd Stephen S. Rich for the Type

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

Julier Grant Morahan Jrn Nerup Concepcion Nierras Flemming Pociot Stephen S. Rich the Type Diabetes Genetics Consortium The common genetic loci that independently influence the risk of type 1 diabetes

Type 1 Diabetes: Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex Families

Patrick Concannon Henry A. Erlich Cecile Julier Grant Morahan Jrn Nerup Flemming Pociot John A. Todd Stephen S. Rich the Type Diabetes Genetics Consortium - Type 1 diabetes is a common