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18 papers found.
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The Change in HbA1c Associated with Initial Adherence and Subsequent Change in Adherence among Diabetes Patients Newly Initiating Metformin Therapy

; Accepted 3 July 2016 Academic Editor: David Strain Copyright © 2016 Gregory A. Nichols et al. This is an open access article distributed under the Creative Commons Attribution License, which permits ... the work as a whole, and have given final approval to the version to be published. Competing Interests Gregory A. Nichols has received research funding from AstraZeneca, Novartis Pharmaceuticals, Incyte

The Association Between Different A1C-Based Measures of Glycemia and Risk of Cardiovascular Disease Hospitalization

Gregory A. Nichols A. Gabriela Rosales Nancy A. Perrin Stephen P. Fortmann We tested whether average monthly glycemic burden (AMGB), a marker of hyperglycemia that is a function of the extent and

Medical Care Costs Associated With Progression of Diabetic Nephropathy

GREGORY A. NICHOLS PHD SUMA VUPPUTURI PHD HELEN LAU MS E p i d e m i o l o g y / H e a l t h OBJECTIVEdTo estimate the direct medical costs of hypertensive patients with type 2 diabetes by the level

Secondary Failure of Metformin Monotherapy in Clinical Practice

OBJECTIVE We sought to document the secondary failure rate of metformin monotherapy in a clinical practice setting and to explore factors that predict therapeutic failure. RESEARCH DESIGN AND METHODS We studied 1,799 type 2 diabetic patients who, between 2004 and 2006, lowered their A1C to <7% after initiating metformin monotherapy as their first-ever anti-hyperglycemic drug. We...

Glycemic Response and Attainment of A1C Goals Following Newly Initiated Insulin Therapy for Type 2 Diabetes

GREGORY A. NICHOLS PHD TERESA M. KIMES MS JOYCE B. HARP TZUYUNG DOUG KOU PHD KIMBERLY G. BRODOVICZ DRPH OBJECTIVEdTo identify the characteristics associated with glycemic response to newly initiated

Independent Contribution of Diabetes to Increased Prevalence and Incidence of Atrial Fibrillation

OBJECTIVE Diabetes has long been recognized as a risk factor for atrial fibrillation, but its independent contribution to atrial fibrillation has not been fully evaluated. We sought to compare the prevalence and incidence of atrial fibrillation in age- and sex-matched patients with and without type 2 diabetes. RESEARCH DESIGN AND METHODS Using an observational cohort design, we...

Higher Medical Care Costs Accompany Impaired Fasting Glucose

OBJECTIVE—The purpose of this study was to estimate medical costs associated with elevated fasting plasma glucose (FPG) and to determine whether costs differed for patients who met the 2003 (≥100 mg/dl) versus the 1997 (≥110 mg/dl) American Diabetes Association (ADA) cut point for impaired fasting glucose. RESEARCH DESIGN AND METHODS—We identified 28,335 patients with two or more...

Trends in Diabetes Incidence Among 7 Million Insured Adults, 2006–2011: The SUPREME-DM Project

Permanente Northwest, Portland, Oregon (Gregory A. Nichols); Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado (Emily B. Schroeder, Stanley Xu, Marsha A. Raebel, John F. Steiner ... approved by all authors. Dr. Gregory A. Nichols is the guarantor of this work and, as such, had full access to all of the data in the study and takes responsibility for the integrity of the data and the

Progression From Newly Acquired Impaired Fasting Glusose to Type 2 Diabetes

OBJECTIVE—We sought to estimate the rate of progression from newly acquired (incident) impaired fasting glucose (IFG) to diabetes under the old and new IFG criteria and to identify predictors of progression to diabetes. RESEARCH DESIGN AND METHODS—We identified 5,452 members of an HMO with no prior history of diabetes, with at least two elevated fasting glucose tests (100–125 mg...

Unadjusted and Adjusted Prevalence of Diagnosed Depression in Type 2 Diabetes

OBJECTIVE—To estimate the prevalence of diagnosed depression in a large population of individuals with type 2 diabetes, compared to a matched control group, and to estimate the extent of depression that is independently associated with diabetes. RESEARCH DESIGN AND METHODS—We compared the prevalence of diagnosed depression in all 16,180 full-year health maintenance organization...

The Burden of Treatment Failure in Type 2 Diabetes

OBJECTIVE—In type 2 diabetes, therapies to maintain blood glucose control usually fail after several years. We estimated the glycemic burden that accumulates from treatment failure and describe the time course and predictors of failure. RESEARCH DESIGN AND METHODS—A prospective, population-based study using retrospective observational data. We identified all 7,208 complete...

The Impact of Cardiovascular Disease on Medical Care Costs in Subjects With and Without Type 2 Diabetes

OBJECTIVE—We examined whether cardiovascular disease (CVD) affects medical care costs differently in subjects with and without diabetes and explored the impact of CVD on costs across the dimensions of age and diabetes duration. RESEARCH DESIGN AND METHODS—We compared the prevalence of CVD and medical care costs for subjects with and without CVD in all 16,180 full-year health...

Weight Change in Diabetes and Glycemic and Blood Pressure Control

ADRIANNE C. FELDSTEIN MS GREGORY A. NICHOLS PHD DAVID H. SMITH RPH MHA PHD VICTOR J. STEVENS PHD KEITH BACHMAN A. GABRIELA ROSALES MS NANCY PERRIN PHD OBJECTIVE - Weight loss in type 2 diabetes is

Treatment Escalation and Rise in HbA1c Following Successful Initial Metformin Therapy

GREGORY A. NICHOLS PHD CHARLES M. ALEXANDER CYNTHIA J. GIRMAN DRPH SACHIN J. KAMAL-BAHL PHD JONATHAN B. BROWN MPP PHD OBJECTIVE - To describe secondary failure of initial metformin therapy in

The Incidence of Congestive Heart Failure in Type 2 Diabetes: An update

An update GREGORY A. NICHOLS PHD CHRISTINA M. GULLION PHD CAROL E. KORO PHD SARA A. EPHROSS PHD JONATHAN B. BROWN PHD MPP E p i d e m i o l o g y / H e a l t h S e r v i c e s / P s y c h o s o c i ... , Portland, Oregon; and 2GlaxoSmithKline, Collegeville, Pennsylvania. Address correspondence and reprint requests to Gregory A. Nichols, PhD, Center for Health Research, 3800 N. Interstate Ave., Portland, OR

Congestive Heart Failure in Type 2 Diabetes: Prevalence, incidence, and risk factors

GREGORY A. NICHOLS PHD 0 TERESA A. HILLIER MS 0 JOHN R. ERBEY PHD JONATHAN B. BROWN PHD MPP 0 0 Kaiser Permanente Center for Health Research , Portland, Oregon, and Schering-Plough Pharmaceu- ticals