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31 papers found.
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Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis

Song, Guang-Hui Liu and Jing Qu declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were followed. Supplementary material

CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells

, Jingyi Li, Liang Sun, Zhenyu Ju, Jian Li, Piu Chan, Guang-Hui Liu, Weiqi Zhang, Moshi l l i t Song and Jing Qu declare that they have no conflict of interest. All institutional and national guidelines for

Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome

GUIDELINES Zeming Wu, Weiqi Zhang, Moshi Song, Wei Wang, Gang Wei, Wei Li, Jinghui Lei, Yu Huang, Yanmei Sang, Piu Chan, Chang Chen, Jing Qu, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte and Guang-Hui Liu

Microstructure and Corrosion Resistance Property of a Zn-AI-Mg Alloy with Different Solidification Processes

-hui Liu 2 0 National Engineering Lab of Advanced Coating Technology for Metal Materials, China Iron and Steel Research Institute Group (CISRI) , Beijing, 100081 , USA 1 Laboratory of Green Recyclable

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described. Mutations in a number of genes including SOD1 and FUS are associated with familial ALS. Here we report the generation of induced pluripotent stem cells (iPSCs) from fibroblasts of familial ALS patients bearing SOD1 +/A272C and FUS +/G1566A...

ROR1, an embryonic protein with an emerging role in cancer biology

. COMPLIANCE WITH ETHICS GUIDELINES Nicholas Borcherding, David Kusner, Guang-Hui Liu and Weizhou Zhang declare that they have no conflict of interest. This article does not contain any studies with human or

CRISPR/Cas9 and TALE: beyond cut and paste

, Ruotong Ren, Jun Wu, Keiichiro Suzuki, Juan Carlos Izpisua Belmonte, and Guang-Hui Liu declare no conflict of interest. This article is distributed under the terms of the Creative Commons Attribution

Vitamin C alleviates aging defects in a stem cell model for Werner syndrome

Ye, Yu Wang, Jian Li, Jie Qiao, Jing Qu, Weiqi Zhang, and Guang-Hui Liu declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory

Inflammasomes in cancer: a double-edged sword

factor-α. COMPLIANCE WITH ETHICS GUIDELINES Ryan Kolb, Guang-Hui Liu, Ann M. Janowski, Fayyaz S. Sutterwala, and Weizhou Zhang declare that they have no conflict of interest. This article does not

Evolution of iPSC disease models

Weiqi Zhang 0 Zhichao Ding 0 Guang-Hui Liu 0 0 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101, China - Human induced pluripotent

Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy

Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human...

Find and replace: editing human genome in pluripotent stem cells

Genetic manipulation of human pluripotent stem cells (hPSCs) provides a powerful tool for modeling diseases and developing future medicine. Recently a number of independent genome-editing techniques were developed, including plasmid, bacterial artificial chromosome, adeno-associated virus vector, zinc finger nuclease, transcription activator-like effecter nuclease, and helper...

Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors

revised in 2000 (5). Informed consent was obtained from all patients for being included in the study. Kejing Zhang, Guang-Hui Liu, Fei Yi, Nuria Montserrat, Tomoaki Hishida, Concepcion Rodriguez Esteban

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

Qiao, Juan Carlos Izpisua Belmonte, Jing Qu, and Guang-Hui Liu declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were