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MTMO: an efficient network-centric algorithm for subtree counting and enumeration

BackgroundThe frequency of small subtrees in biological, social, and other types of networks could shed light into the structure, function, and evolution of such networks. However, counting all possible subtrees of a prescribed size can be computationally expensive because of their potentially large number even in small, sparse networks. Moreover, most of the existing algorithms...

Combined small RNA and gene expression analysis revealed roles of miRNAs in maize response to rice black-streaked dwarf virus infection

Author notes Aiqin Li and Guanghui Li contributed equally. AffiliationsBiotechnology Research Center, Shandong Academy of Agricultural Sciences; Shandong Provincial Key Laboratory of Crop Genetic ... Improvement, Ecology and Physiology, Jinan, 250100, PR ChinaAiqin Li, Guanghui Li, Changsheng Li, Ye Zhang, Pengcheng Li, Han Xia, Shuzhen Zhao, Lei Hou, Chuanzhi Zhao & Xingjun WangCollege of Life Sciences

Study on the Multi-level Resistance-Switching Memory and Memory-State-Dependent Photovoltage in Pt/Nd:SrTiO3 Junctions

Pt/Nd:SrTiO3 (STO)/In devices were fabricated by depositing Schottky-contact Pt and Ohmic-contact In electrodes on a single crystal STO with Nd doping. The Pt/Nd:STO/In devices show multi-level resistance-switching (RS) memory and memory-state-dependent photovoltage (PV) effects, which can be controlled by the applied pulse width or magnitude. Both the RS and PV are related to...

Adverse obstetric outcomes in pregnant women with uterine fibroids in China: A multicenter survey involving 112,403 deliveries

Zhao, Xin Wang, Yi Chen. Methodology: Rong Zhao, Weiyuan Zhang. Data curation: Rong Zhao, Xin Wang, Liying Zou, Guanghui Li, Yi Chen, Changdong Li. Project administration: Rong Zhao, Weiyuan Zhang

Construction of a synthetic phage-displayed Nanobody library with CDR3 regions randomized by trinucleotide cassettes for diagnostic applications

Background Nanobodies (Nbs) have proved their great value as therapeutic molecules and clinical diagnostic tools. Although the routine procedure to obtain Nbs is to immunize camels with antigens, it is unavailable to immunize a camel when the antigens are highly toxic, pathogenic or nonimmunogenic. A synthetic phage display library is an alternative to generate Nbs against such...

A transcriptome profile in hepatocellular carcinomas based on integrated analysis of microarray studies

Background Despite new treatment options for hepatocellular carcinomas (HCC) recently, 5-year survival remains poor, ranging from 50 to 70%, which may attribute to the lack of early diagnostic biomarkers. Thus, developing new biomarkers for early diagnosis of HCC, is extremely urgent, aiming to decrease HCC-related deaths. Methods In the study, we conducted a comprehensive...

Rational selection and engineering of exogenous principal sigma factor (σHrdB) to increase teicoplanin production in an industrial strain of Actinoplanes teichomyceticus

Background Transcriptional engineering has presented a strong ability of phenotypic improvement in microorganisms. However, it could not be directly applied to Actinoplanes teichomyceticus L-27 because of the paucity of endogenous transcription factors in the strain. In this study, exogenous transcription factors were rationally selected and transcriptional engineering was...

Cross sectional study in China: fetal gender has adverse perinatal outcomes in mainland China

Background The association between fetal gender and pregnancy outcomes has been thoroughly demonstrated in western populations. However, this association has not been thoroughly documented in China. The primary objective of the present study is to determine whether the association of adverse pregnancy and labour outcomes with male fetuses applies to the Chinese population...

A descriptive analysis of the indications for caesarean section in mainland China

Background In recent decades we have observed a remarkable increase in the rate of caesarean section (CS) in both developed and developing countries, especially in China. However, the real reasons for this phenomenon are uncertain. Notably, the number of women requesting elective CS without accepted valid medical indication has also increased, generating a nationwide debate...

Influence of Oil Viscosity on Alkaline Flooding for Enhanced Heavy Oil Recovery

Oil viscosity was studied as an important factor for alkaline flooding based on the mechanism of “water drops” flow. Alkaline flooding for two oil samples with different viscosities but similar acid numbers was compared. Besides, series flooding tests for the same oil sample were conducted at different temperatures and permeabilities. The results of flooding tests indicated that...

An epidemiological survey on low birth weight infants in China and analysis of outcomes of full-term low birth weight infants

Background Low birth weight (LBW) is one of the leading causes of adverse perinatal outcomes and is closely related to neonatal disease and death. The incidence of LBW has been increasing. The aim of this study was to investigate the current incidence rate and factors affecting low birth weight infants and perinatal outcomes of full-term low birth weight infants in mainland China...

The Fosfomycin Resistance Gene fosB3 Is Located on a Transferable, Extrachromosomal Circular Intermediate in Clinical Enterococcus faecium Isolates

Some VanM-type vancomycin-resistant Enterococcus faecium isolates from China are also resistant to fosfomycin. To investigate the mechanism of fosfomycin resistance in these clinical isolates, antimicrobial susceptibility testing, filter-mating, Illumina/Solexa sequencing, inverse PCR and fosfomycin resistance gene cloning were performed. Three E. faecium clinical isolates were...

Effect of Calcitonin Gene-Related Peptide on the Neurogenesis of Rat Adipose-Derived Stem Cells In Vitro

Calcitonin gene-related peptide (CGRP) promotes neuron recruitment and neurogenic activity. However, no evidence suggests that CGRP affects the ability of stem cells to differentiate toward neurogenesis. In this study, we genetically modified rat adipose-derived stem cells (ADSCs) with the CGRP gene (CGRP-ADSCs) and subsequently cultured in complete neural-induced medium. The...

The 2011 Survey on Hypertensive Disorders of Pregnancy (HDP) in China: Prevalence, Risk Factors, Complications, Pregnancy and Perinatal Outcomes

Hypertensive disorders of pregnancy (HDP) are a group of medical complications in pregnancy and also a risk factor for severe pregnancy outcomes, but it lacks a large-scale epidemiological investigation in recent years. This survey represents a multicenter cross-sectional retrospective study to estimate the prevalence and analyze the risk factors for HDP among the pregnant women...

Gene silencing of heparanase results in suppression of invasion and migration of hepatoma cells

Background This study investigated the effect of transcriptional gene silencing (TGS) of the heparanase gene on hepatoma SMCC-7721 cells. Methods SiRNAs targeting the promoter region and coding region of the heparanase gene were designed and synthesized. Then the siRNAs were transfected into hepatoma SMCC-7721 cells by nuclear transfection or cytoplasmic transfection. The...

Effects of the epigenetic drug MS-275 on the release and function of exosome-related immune molecules in hepatocellular carcinoma cells

Background Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce anti-tumor immune responses. In the current study, we aim to investigate the regulatory effect of the epigenetic drug MS-275 on hepatoma G2 (HepG2) cell-derived exosomes, especially for their immunostimulatory properties and alteration of some non-specific immune protein...

Th1-Mediated Immunity against Helicobacter pylori Can Compensate for Lack of Th17 Cells and Can Protect Mice in the Absence of Immunization

Helicobacter pylori (H. pylori) infection can be significantly reduced by immunization in mice. Th17 cells play an essential role in the protective immune response. Th1 immunity has also been demonstrated to play a role in the protective immune response and can compensate in the absence of IL-17. To further address the potential of Th1 immunity, we investigated the efficacy of...

Synthesis and characterization of fluorinated crosslinkable poly(phthalazinone ether)s bearing tetrafluorostyrene groups for optical waveguides

A series of novel fluorinated crosslinkable poly(phthalazinone ether)s bearing tetrafluorostyrene groups (FSt-FPPEs) was prepared by polycondensation from 4-(4′-hydroxyphenyl)-phthalazin-1(2 H)-one (DHPZ), decafluorobiphenyl, 4,4-(hexafluoroisopropylidene)diphenol (6F-BPA) and pentafluorostyrene (FSt) for optical waveguide applications. The obtained polymers exhibited good...

Synthesis and Thermotropic Liquid Crystalline Behavior of Novel Main-Chain Poly(aryl ether ketones) Copolymer Containing Phthalazinone Moiety and Biphenyl Mesogen

Jinyan WANG Kejia JIN Guixian SU Guanghui LI Xigao JIAN A novel thermotropic liquid crystalline poly(aryl ether ketones) copolymer containing phthalazinone moiety and biphenyl mesogen named P-5050 was