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13 papers found.
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Functional diversity of topological modules in human protein-protein interaction networks

biological similarity between the two phenotype vectors that corresponded to the two modules. cos(VA, V ) = B VA ? VB |VA| |VB| (5) (6) Author Contributions Guangming Liu, Xuezhong Zhou and Jian Yu ... conceived the experiment(s), Guangming Liu and Huixin Wang conducted the experiment(s), Guangming Liu and Hongwei Chu analysed the results. All authors reviewed the manuscript. Additional Information

Analysis of Startup Process and Its Optimization for a Two-Stand Reversible Cold Rolling Mill

should be addressed to Guangming Liu; moc.621@8002uilthgirb Received 20 May 2017; Accepted 28 August 2017; Published 10 October 2017 Academic Editor: Marco Rossi Copyright © 2017 Guangming Liu et al

Analysis of Startup Process and Its Optimization for a Two-Stand Reversible Cold Rolling Mill

should be addressed to Guangming Liu; moc.621@8002uilthgirb Received 20 May 2017; Accepted 28 August 2017; Published 10 October 2017 Academic Editor: Marco Rossi Copyright © 2017 Guangming Liu et al

A New Resources Provisioning Method Based on QoS Differentiation and VM Resizing in IaaS

In order to improve the host energy efficiency in IaaS, we proposed an adaptive host resource provisioning method, CoST, which is based on QoS differentiation and VM resizing. The control model can adaptively adjust control parameters according to real time application performance, in order to cope with changes in load. CoST takes advantage of the fact that different types of...

G2LC: Resources Autoscaling for Real Time Bioinformatics Applications in IaaS

Cloud computing has started to change the way how bioinformatics research is being carried out. Researchers who have taken advantage of this technology can process larger amounts of data and speed up scientific discovery. The variability in data volume results in variable computing requirements. Therefore, bioinformatics researchers are pursuing more reliable and efficient...

G2LC: Resources Autoscaling for Real Time Bioinformatics Applications in IaaS

Cloud computing has started to change the way how bioinformatics research is being carried out. Researchers who have taken advantage of this technology can process larger amounts of data and speed up scientific discovery. The variability in data volume results in variable computing requirements. Therefore, bioinformatics researchers are pursuing more reliable and efficient...

Integrated network analysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies

Epilepsy is a complex neurological disorder and a significant health problem. The pathogenesis of epilepsy remains obscure in a significant number of patients and the current treatment options are not adequate in about a third of individuals which were known as refractory epilepsies (RE). Network medicine provides an effective approach for studying the molecular mechanisms...

Efficient Resources Provisioning Based on Load Forecasting in Cloud

Cloud providers should ensure QoS while maximizing resources utilization. One optimal strategy is to timely allocate resources in a fine-grained mode according to application’s actual resources demand. The necessary precondition of this strategy is obtaining future load information in advance. We propose a multi-step-ahead load forecasting method, KSwSVR, based on statistical...

Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves’ Orbitopathy

Aim. To study the efficacy and safety of subantimicrobial dose (SD) doxycycline(50 mg/d) in patients with active and moderate-to-severe Graves’ orbitopathy (GO). Methods. Thirteen patients with active and moderate-to-severe GO received once daily oral doxycycline (50 mg/d) for 12 wk. Treatment response at 24 wk was used as the primary outcome, measured by a composite of...

Efficacy of Subantimicrobial Dose Doxycycline for Moderate-to-Severe and Active Graves’ Orbitopathy

Aim. To study the efficacy and safety of subantimicrobial dose (SD) doxycycline(50 mg/d) in patients with active and moderate-to-severe Graves’ orbitopathy (GO). Methods. Thirteen patients with active and moderate-to-severe GO received once daily oral doxycycline (50 mg/d) for 12 wk. Treatment response at 24 wk was used as the primary outcome, measured by a composite of...

Decreased Tumor Progression and Invasion by a Novel Anti-Cell Motility Target for Human Colorectal Carcinoma Cells

We have previously described a novel modulator of the actin cytoskeleton that also regulates Ras and mitogen-activated protein kinase activities in TGFβ-sensitive epithelial cells. Here we examined the functional role of this signaling regulatory protein (km23-1) in mediating the migration, invasion, and tumor growth of human colorectal carcinoma (CRC) cells. We show that small...

Investigation of the interfacial water structure on poly[2-(dimethylamino)ethyl methacrylate] at the air/water interface by sum frequency generation vibrational spectroscopy

The effect of pH on the conformation of surface alkyl groups and the structure of interfacial water molecules on poly[2-(dimethylamino)ethyl methacrylate] (PDEM) at the air/water interface were investigated with sum frequency generation vibrational spectroscopy (SFG-VS). At pH 4.1, the hydrogen bonding SFG spectra were similar to that of the air/pure water interface. As the pH...

Two-Step Source Tracing Strategy of Yersinia pestis and Its Historical Epidemiology in a Specific Region

Source tracing of pathogens is critical for the control and prevention of infectious diseases. Genome sequencing by high throughput technologies is currently feasible and popular, leading to the burst of deciphered bacterial genome sequences. Utilizing the flooding genomic data for source tracing of pathogens in outbreaks is promising, and challenging as well. Here, we employed...