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Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53

Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, Jiangsu, 215123, ChinaLiang Zhou & Guoqiang Xu AuthorsSearch for Liang Zhou in:Nature Research journals ... • PubMed • Google Scholar Search for Guoqiang Xu in:Nature Research journals • PubMed • Google Scholar Conflict of interest The authors declare that they have no conflict of interest. Corresponding

Correction: Exploration of Serum Proteomic Profiling and Diagnostic Model That Differentiate Crohn’s Disease and Intestinal Tuberculosis

Guodong Shan Hongtan Chen Ming Yang Wenguo Chen Jiekai Yu Guoqiang Xu In the Funding section, the name of the funder is listed incorrectly. The correct funder is: Medical Science Research Foundation of

Isolation and characterization of Bacillus sp. GFP-2, a novel Bacillus strain with antimicrobial activities, from Whitespotted bamboo shark intestine

The abuse of antibiotics and following rapidly increasing of antibiotic-resistant pathogens is the serious threat to our society. Natural products from microorganism are regarded as the important substitution antimicrobial agents of antibiotics. We isolated a new strain, Bacillus sp. GFP-2, from the Chiloscyllium plagiosum (Whitespotted bamboo shark) intestine, which showed great...

Exploration of Serum Proteomic Profiling and Diagnostic Model That Differentiate Crohn's Disease and Intestinal Tuberculosis

Aim To explore the diagnostic models of Crohn’s disease (CD), Intestinal tuberculosis (ITB) and the differential diagnostic model between CD and ITB by analyzing serum proteome profiles. Methods Serum proteome profiles from 30 CD patients, 21 ITB patients and 30 healthy controls (HCs) were analyzed by using weak cationic magnetic beads combined with MALDI-TOF-MS technique to...

Coupled local translation and degradation regulate growth cone collapse

Medical College, Cornell University, 1300 York Avenue, New York, New York 10065, USAAlessia Deglincerti, Dilek Colak, Ulrich Hengst, Guoqiang Xu & Samie R. JaffreyJiangsu Key Laboratory of Translational ... 215123, ChinaYaobin Liu & Guoqiang Xu AuthorsSearch for Alessia Deglincerti in:Nature Research journals • PubMed • Google ScholarSearch for Yaobin Liu in:Nature Research journals • PubMed • Google

Reconstruction of cytosolic fumaric acid biosynthetic pathways in Saccharomyces cerevisiae

Background Fumaric acid is a commercially important component of foodstuffs, pharmaceuticals and industrial materials, yet the current methods of production are unsustainable and ecologically destructive. Results In this study, the fumarate biosynthetic pathway involving reductive reactions of the tricarboxylic acid cycle was exogenously introduced in S. cerevisiae by a series of...

Computational Prediction and Validation of BAHD1 as a Novel Molecule for Ulcerative Colitis

Guoqiang Xu in:Nature Research journals • PubMed • Google Scholar Contributions The co-first authors H.T.Z, X.Y.W. and J.L. were responsible for performing the main experiment, the analysis and the writing ... . Corresponding author Correspondence to Guoqiang Xu. Supplementary information Word documents1.Supplementary Information Rights and permissions This work is licensed under a Creative Commons Attribution

Fumaric Acid Production in Saccharomyces cerevisiae by In Silico Aided Metabolic Engineering

Fumaric acid (FA) is a promising biomass-derived building-block chemical. Bio-based FA production from renewable feedstock is a promising and sustainable alternative to petroleum-based chemical synthesis. Here we report on FA production by direct fermentation using metabolically engineered Saccharomyces cerevisiae with the aid of in silico analysis of a genome-scale metabolic...

Dissimilarity in the oxidative folding of onconase and ribonuclease A, two structural homologues

The oxidative folding of frog onconase (ONC), a member of the ribonuclease A family, was examined and shows markedly different behavior compared to its structural homologue bovine pancreatic ribonuclease A (RNase A) under similar conditions. Application of a reduction pulse (using a small amount of reduced dithiothreitol) during the oxidative regeneration of ONC indicated the...