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RNA editing is abundant and correlates with task performance in a social bumblebee

Colonies of the bumblebee Bombus terrestris are characterized by wide phenotypic variability among genetically similar full-sister workers, suggesting a major role for epigenetic processes. Here, we report a high level of ADAR-mediated RNA editing in the bumblebee, despite the lack of an ADAR1-homolog. We identify 1.15 million unique genomic sites, and 164 recoding sites residing...

Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance

Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional modification catalyzed by the ADAR (adenosine deaminase that acts on RNA) enzymes, which are ubiquitously expressed among metazoans. Technical requirements have limited systematic mapping of editing sites to a small number of organisms. Thus, the extent of editing across the metazoan lineage is largely unknown...

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

Hagit T. Porath, Erez Y. Levanon, Ninette Amariglio & Ron UngerDepartment of Molecular Genetics, Weizmann Institute of Science, 76100, Rehovot, IsraelOrel Mizrahi & Noam Stern-GinossarSackler School of ... Research journals • PubMed • Google Scholar Search for Karen Cesarkas in:Nature Research journals • PubMed • Google Scholar Search for Hagit T. Porath in:Nature Research journals • PubMed • Google Scholar