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Using whole genome scores to compare three clinical phenotyping methods in complex diseases

, 02145, USADavid W. Bates & Adam Wright AuthorsSearch for Wenyu Song in:Nature Research journals • PubMed • Google Scholar Search for Hailiang Huang in:Nature Research journals • PubMed • Google Scholar

Genetic variants in cellular transport do not affect mesalamine response in ulcerative colitis

Conceptualization: Christopher J. Moran, Hailiang Huang, Manuel Rivas, Jess L. Kaplan, Mark J. Daly, Harland S. Winter. Data curation: Christopher J. Moran. Formal analysis: Christopher J. Moran, Hailiang Huang ... . Funding acquisition: Christopher J. Moran, Harland S. Winter. Methodology: Christopher J. Moran, Hailiang Huang, Harland S. Winter. 7 / 9 Supervision: Mark J. Daly, Harland S. Winter. Writing ± original

Fabrication of Ordered Nanopattern by using ABC Triblock Copolymer with Salt in Toluene

Ordered nanopatterns of triblock copolymer polystyrene-block-poly(2-vinylpyridine)-block- poly (ethylene oxide)(PS-b-P2VP-b-PEO) have been achieved by the addition of lithium chloride (LiCl). The morphological and structural evolution of PS-b-P2VP-b-PEO/LiCl thin films were systematically investigated by varying different experimental parameters, including the treatment for...

Synthetic immunity to break down the bottleneck of cancer immunotherapy

As a result of recent breakthroughs in cancer immunotherapies, unprecedented and durable remission, and even cure, has been reported in some patients. Importantly, this progress has been achieved, not by the induction of immunity, but by the delivery of immunity in the form of engineered antibodies (eAbs) or effector T cells. However, these single-target technologies have failed...

BlueSNP: R package for highly scalable genome-wide association studies using Hadoop clusters

Summary: Computational workloads for genome-wide association studies (GWAS) are growing in scale and complexity outpacing the capabilities of single-threaded software designed for personal computers. The BlueSNP R package implements GWAS statistical tests in the R programming language and executes the calculations across computer clusters configured with Apache Hadoop, a de facto...

Fast Association Tests for Genes with FAST

Gene-based tests of association can increase the power of a genome-wide association study by aggregating multiple independent effects across a gene or locus into a single stronger signal. Recent gene-based tests have distinct approaches to selecting which variants to aggregate within a locus, modeling the effects of linkage disequilibrium, representing fractional allele counts...

Targeting Human Telomeric G-Quadruplex DNA and Inhibition of Telomerase Activity With [(dmb)2Ru(obip)Ru(dmb)2]4+

Inhibition of telomerase by inducing/stabilizing G-quadruplex formation is a promising strategy to design new anticancer drugs. We synthesized and characterized a new dinuclear complex [(dmb)2Ru(obip)Ru(dmb)2]4+ (dmb = 4,4’-dimethyl-2,2’-bipyridine, obip = (2-(2-pyridyl)imidazo[4,5-f][1,10]phenanthroline) with high affinity for both antiparallel and mixed parallel / antiparallel...

Precision and recall estimates for two-hybrid screens

Hailiang Huang 0 Joel S. Bader 0 Associate Editor: Alfonso Valencia 0 Department of Biomedical Engineering and High-Throughput Biology Center, Johns Hopkins University , Baltimore, MD, USA

Gene-Based Tests of Association

Genome-wide association studies (GWAS) are now used routinely to identify SNPs associated with complex human phenotypes. In several cases, multiple variants within a gene contribute independently to disease risk. Here we introduce a novel Gene-Wide Significance (GWiS) test that uses greedy Bayesian model selection to identify the independent effects within a gene, which are...

Where Have All the Interactions Gone? Estimating the Coverage of Two-Hybrid Protein Interaction Maps

Yeast two-hybrid screens are an important method for mapping pairwise physical interactions between proteins. The fraction of interactions detected in independent screens can be very small, and an outstanding challenge is to determine the reason for the low overlap. Low overlap can arise from either a high false-discovery rate (interaction sets have low overlap because each set...

Complex host genetics influence the microbiome in inflammatory bowel disease

Huang 5 Andrea D Tyler 7 Suzanne van Sommeren 6 10 Floris Imhann 6 10 Joanne M Stempak 7 Hu Huang 9 Pajau Vangay 9 Gabriel A Al-Ghalith 9 Caitlin Russell 3 4 Jenny Sauk 4 Jo Knight 13 Mark J Daly 1 11 14