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Evaluating architecture impact on system energy efficiency

Science Foundation of China (Grant No. 61502019). Author Contributions Data curation: Shijie Yu. Formal analysis: Shijie Yu. Funding acquisition: Hailong Yang. Investigation: Shijie Yu. Resources ... : Hailong Yang, Depei Qian. Software: Shijie Yu. Supervision: Hailong Yang. Validation: Shijie Yu. Visualization: Shijie Yu. Conceptualization: Hailong Yang, Rui Wang, Zhongzhi Luan, Depei Qian

Speeding up profiling program’s runtime characteristics for workload consolidation

Workload consolidation is a common method to increase resource utilization of the clusters or data centers while still trying to ensure the performance of the workloads. In order to get the maximum benefit from workload consolidation, the task scheduler has to understand the runtime characteristics of the individual program and schedule the programs with less resource conflict...

The first identified cathelicidin from tree frogs possesses anti-inflammatory and partial LPS neutralization activities

As of February 2017, approximately 7639 amphibian species have been described in the AmphibiaWeb database. However, only 20 cathelicidin-like antimicrobial peptides have been identified to date from 10 amphibian species. Half of these peptides were identified from genome sequences and have not yet been functionally characterized. In this study, a novel cathelicidin-like peptide...

Performance Optimization of Marine Science and Numerical Modeling on HPC Cluster

Marine science and numerical modeling (MASNUM) is widely used in forecasting ocean wave movement, through simulating the variation tendency of the ocean wave. Although efforts have been devoted to improve the performance of MASNUM from various aspects by existing work, there is still large space unexplored for further performance improvement. In this paper, we aim at improving...

Balancing the Lifetime and Storage Overhead on Error Correction for Phase Change Memory

As DRAM is facing the scaling difficulty in terms of energy cost and reliability, some nonvolatile storage materials were proposed to be the substitute or supplement of main memory. Phase Change Memory (PCM) is one of the most promising nonvolatile memory that could be put into use in the near future. However, before becoming a qualified main memory technology, PCM should be...

A cecropin-like antimicrobial peptide with anti-inflammatory activity from the black fly salivary glands

Background Several antimicrobial peptides (AMPs) belonging to the cecropin family have been identified from the salivary glands of different black fly species, however, the immunological functions for these molecules were poorly understood. Methods A novel cecropin-like antimicrobial peptide (SibaCec) was purified using reverse phase high-performance liquid chromatography (RP...

A potent anti-inflammatory peptide from the salivary glands of horsefly

Background A diverse group of physiologically active peptides/proteins are present in the salivary glands of horsefly Tabanus yao (Diptera, Tabanidae) that facilitate acquisition of blood meal. However, their roles in the regulation of local inflammation remains poorly understood. Methods Induction expression profiles of immune-related molecules in the salivary glands of T. yao...

Purification and characterization of a novel defensin from the salivary glands of the black fly, Simulium bannaense

Background Black flies (Diptera: Simuliidae) are haematophagous insects that can cause allergic reactions and act as vectors of pathogens. Although their saliva has been thought to contain a diverse array of physiologically active molecules, little information is available on antimicrobial factors in black fly salivary glands, especially no defensins have been reported so far...

Effect of hypobaric storage on quality, antioxidant enzyme and antioxidant capability of the Chinese bayberry fruits

BackgroundThe Chinese bayberry (Myrica rubra Sieb. and Zucc.) is a subtropical fruit native to China, with unique flavor, sweet and sour taste, and high nutrition and health values. The fruit is highly perishable and susceptible to mechanical injury, physiological deterioration and fungal decay once harvested. This study was to investigate the effect of hypobaric storage on the...

Mn-ion-enhanced red spectral emission from yttrium aluminum garnet doped cerium phosphor

Mn ions were co-doped in yttrium aluminum garnet doped cerium (YAG:Ce) phosphors as a co-activator and host lattice element using the co-precipitation method. These ions broadened the emission spectra of the pure YAG:Ce phosphor, which is caused by the 2E-4A2, 5E-5T2 or 1T2-5T2 transition. From our X-ray diffraction results, we observed that Ce3+ (1.032 Å) was substituted at the...

Cathelicidin-BF, a Snake Cathelicidin-Derived Antimicrobial Peptide, Could Be an Excellent Therapeutic Agent for Acne Vulgaris

Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and it is the first identified cathelicidin antimicrobial peptide in reptiles. In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium...

A Bi-Functional Anti-Thrombosis Protein Containing Both Direct-Acting Fibrin(ogen)olytic and Plasminogen-Activating Activities

Direct-acting fibrin(ogen)olytic agents such as plasmin have been proved to contain effective and safety thrombolytic potential. Unfortunately, plasmin is ineffective when administered by the intravenous route because it was neutralized by plasma antiplasmin. Direct-acting fibrin(ogen)olytic agents with resistance against antiplasmin will brighten the prospect of anti-thrombosis...

Snake Cathelicidin from Bungarus fasciatus Is a Potent Peptide Antibiotics

Background Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules of innate immunity, which are firstly found in mammalians. Recently, several cathelicidins have also been found from chickens and fishes. No cathelicidins from other non-mammalian vertebrates have been reported. Principal Findings In this work, a cathelicidin-like...

Odorranalectin Is a Small Peptide Lectin with Potential for Drug Delivery and Targeting

BackgroundLectins are sugar-binding proteins that specifically recognize sugar complexes. Based on the specificity of protein–sugar interactions, different lectins could be used as carrier molecules to target drugs specifically to different cells which express different glycan arrays. In spite of lectin's interesting biological potential for drug targeting and delivery, a...