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Evaluating architecture impact on system energy efficiency

Science Foundation of China (Grant No. 61502019). Author Contributions Data curation: Shijie Yu. Formal analysis: Shijie Yu. Funding acquisition: Hailong Yang. Investigation: Shijie Yu. Resources ... : Hailong Yang, Depei Qian. Software: Shijie Yu. Supervision: Hailong Yang. Validation: Shijie Yu. Visualization: Shijie Yu. Conceptualization: Hailong Yang, Rui Wang, Zhongzhi Luan, Depei Qian

Speeding up profiling program’s runtime characteristics for workload consolidation

Workload consolidation is a common method to increase resource utilization of the clusters or data centers while still trying to ensure the performance of the workloads. In order to get the maximum benefit from workload consolidation, the task scheduler has to understand the runtime characteristics of the individual program and schedule the programs with less resource conflict...

Performance Optimization of Marine Science and Numerical Modeling on HPC Cluster

Marine science and numerical modeling (MASNUM) is widely used in forecasting ocean wave movement, through simulating the variation tendency of the ocean wave. Although efforts have been devoted to improve the performance of MASNUM from various aspects by existing work, there is still large space unexplored for further performance improvement. In this paper, we aim at improving...

Balancing the Lifetime and Storage Overhead on Error Correction for Phase Change Memory

As DRAM is facing the scaling difficulty in terms of energy cost and reliability, some nonvolatile storage materials were proposed to be the substitute or supplement of main memory. Phase Change Memory (PCM) is one of the most promising nonvolatile memory that could be put into use in the near future. However, before becoming a qualified main memory technology, PCM should be...

Cathelicidin-BF, a Snake Cathelicidin-Derived Antimicrobial Peptide, Could Be an Excellent Therapeutic Agent for Acne Vulgaris

Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and it is the first identified cathelicidin antimicrobial peptide in reptiles. In this study, cathelicidin-BF was found exerting strong antibacterial activities against Propionibacterium...

A Bi-Functional Anti-Thrombosis Protein Containing Both Direct-Acting Fibrin(ogen)olytic and Plasminogen-Activating Activities

Direct-acting fibrin(ogen)olytic agents such as plasmin have been proved to contain effective and safety thrombolytic potential. Unfortunately, plasmin is ineffective when administered by the intravenous route because it was neutralized by plasma antiplasmin. Direct-acting fibrin(ogen)olytic agents with resistance against antiplasmin will brighten the prospect of anti-thrombosis...

Snake Cathelicidin from Bungarus fasciatus Is a Potent Peptide Antibiotics

Background Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules of innate immunity, which are firstly found in mammalians. Recently, several cathelicidins have also been found from chickens and fishes. No cathelicidins from other non-mammalian vertebrates have been reported. Principal Findings In this work, a cathelicidin-like...

Odorranalectin Is a Small Peptide Lectin with Potential for Drug Delivery and Targeting

BackgroundLectins are sugar-binding proteins that specifically recognize sugar complexes. Based on the specificity of protein–sugar interactions, different lectins could be used as carrier molecules to target drugs specifically to different cells which express different glycan arrays. In spite of lectin's interesting biological potential for drug targeting and delivery, a...