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17 papers found.
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Computational study on a puzzle in the biosynthetic pathway of anthocyanin: Why is an enzymatic oxidation/ reduction process required for a simple tautomerization?

Uchiyama. Funding acquisition: Mami Yamazaki, Kazuki Saito, Masanobu Uchiyama. Formal analysis: Hajime Sato. Supervision: Masanobu Uchiyama. Project administration: Chao Wang, Masanobu Uchiyama. Writing ... ± original draft: Hajime Sato, Chao Wang. 1. Feild TS , Lee DW , Holbrook NM . Why Leaves Turn Red in Autumn. The Role of Anthocyanins in Senescing Leaves of Red-Osier Dogwood . Plant Physiol . 2001 ; 127

Theoretical Study of Sesterfisherol Biosynthesis: Computational Prediction of Key Amino Acid Residue in Terpene Synthase

–8657, JapanTakeo Tomita AuthorsSearch for Hajime Sato in:Nature Research journals • PubMed • Google Scholar Search for Koji Narita in:Nature Research journals • PubMed • Google Scholar Search for ... . Competing Interests The authors declare that they have no competing interests. Corresponding authors Correspondence to Hajime Sato or Masanobu Uchiyama. Electronic supplementary material Supplementary

Emergency and disaster preparedness for chronically ill patients: a review of recommendations

authors (Jun Tomio and Hajime Sato) summarized the findings. The recommendations were summarized specifically for each major illness and for each type of stakeholder. They also included additional findings

Characteristics of clinical trial websites: information distribution between ClinicalTrials.gov and 13 primary registries in the WHO registry network

Background It is well known that information about clinical trials is not easily accessible by the public. In Japan, clinical trial information can be accessed by the general public through online registries; however, many people find these registries difficult to use. To improve current clinical trial registries, we propose that combining them with clinical information phrased...

A role of CB1R in inducing θ-rhythm coordination between the gustatory and gastrointestinal insula

. Author information Author notesYoungnam Kang, Hajime Sato & Mitsuru Saito These authors contributed equally to this work. AffiliationsDepartment of Neuroscience and Oral Physiology, Osaka University ... Graduate School of Dentistry, Suita, Osaka 565-0871, JapanYoungnam Kang, Hajime Sato, Mitsuru Saito, Dong Xu Yin & Hiroki ToyodaDepartment of Oral Physiology, Graduate School of Medical and Dental Sciences

Countermeasures and vaccination against terrorism using smallpox: pre-event and post-event smallpox vaccination and its contraindications

Smallpox, when used as a biological weapon, presents a serious threat to civilian populations. Core components of the public health management of a terrorism attack using smallpox are: vaccination (ring vaccination and mass vaccination), adverse event monitoring, confirmed and suspected smallpox case management, contact management, identifying, tracing, monitoring contacts, and...

Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis

Background Principal component analysis (PCA) has been widely used to visualize high-dimensional metabolomic data in a two- or three-dimensional subspace. In metabolomics, some metabolites (e.g., the top 10 metabolites) have been subjectively selected when using factor loading in PCA, and biological inferences are made for these metabolites. However, this approach may lead to...

Endoscopic nasobiliary drainage for obstructive jaundice using either a 5 Fr or 7 Fr catheter: a prospective, randomized trial

Background The influence of size on the effectiveness of nasobiliary catheters has not yet been studied. We compared biliary drainage effectiveness and procedure-related discomfort and adverse events in 5 French (Fr) and 7 Fr nasobiliary catheters. Methods We prospectively studied 100 patients undergoing endoscopic biliary drainage for obstructive jaundice, who were randomly...

Disparity in disaster preparedness among rheumatoid arthritis patients with various general health, functional, and disability conditions

To describe disaster preparedness among chronically ill patients and to examine how differences in health, functional, and disability conditions are associated with disaster preparedness, focusing on rheumatoid arthritis (RA) patients with various functional and disability levels. In 2007, 1,477 members of a nationwide RA patient group in Japan who lived in municipalities...

Simple preoperative computed tomography image analysis shows good predictive performance for pathological vessel invasion in clinical stage IA non-small cell lung cancer†

OBJECTIVES Pathological vessel invasion is a well-known prognostic factor in early-stage, non-small cell lung cancer and preoperative predicting vessel invasion may enable us to improve prognosis by additional interventions. We evaluated the importance of vessel invasion as a prognostic factor in clinical stage IA non-small cell lung cancer and predictive performance of simple...

Hypertriglyceridemia as a possible cause of coma: a case report

Introduction Many studies suggest that elevated triglyceride levels are associated with increased long-term risk of stroke, including transient ischemic attacks. In addition, elevated triglyceride levels independently contribute to plasma viscosity and decreased blood flow. However, no consensus has been reached regarding the significance of hypertriglyceridemia as an independent...

Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry

Metabolic microenvironment of tumor cells is influenced by oncogenic signaling and tissue-specific metabolic demands, blood supply, and enzyme expression. To elucidate tumor-specific metabolism, we compared the metabolomics of normal and tumor tissues surgically resected pairwise from nine lung and seven prostate cancer patients, using capillary electrophoresis time-of-flight...

Miniaturized cardiopulmonary bypass system in neonates and small infants

Cardiopulmonary bypass (CPB) in children is associated with a capillary leak due to inflammatory response, which results in an increase in total body water. This study was designed to reveal that our miniaturized CPB system reduced the peri-operative systemic inflammatory response in small infants. In our institution, the priming volume has been reduced from 500 ml to 140 ml...

Multiplex PCR amplification of TH01, D9S304, and D3S1744 loci

A multiplex typing method of the tetrameric short tandem repeat (STR) loci TH01, D9S304, and D3S1744 was developed. The allelic ladder included alleles 6–11 (80–100 bp) and 9.3 (95 bp) for TH01, alleles 6–15 (125–161 bp) for D9S304, and alleles 13–22 (174–210 bp) for D3S1744. The observed heterozygosity of D9S304 was 0.851. The combined discrimination power of the three loci was...

Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration

Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be protective for risk of a number of conditions, including cardiovascular disease and chronic kidney disease, as well as numerous autoimmune disorders such as...

Formation of sheared G:A base pairs in an RNA duplex modelled after ribozymes, as revealed by NMR

The thermal stability and structure of an RNA duplex, r(GGACGAGUCC)2, the base sequence of which was modelled after both a hammerhead ribozyme and a lead ribozyme, were studied by CD and NMR. We previously demonstrated that the corresponding DNA duplex, d(GGACGAGTCC)2, formed unique ‘sheared’ G:A base pairs, where an amino proton, instead of an imino proton, of G is involved in...