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Genome-wide analysis of DNA polymorphisms, the methylome and transcriptome revealed that multiple factors are associated with low pollen fertility in autotetraploid rice

) for the technical assistance and data Conceptualization: Xiang Li, Xiangdong Liu. Data curation: Xiang Li, Hang Yu, Muhammad Qasim Shahid, Jinwen Wu. Formal analysis: Xiang Li, Hang Yu, Muhammad Qasim ... Shahid, Jinwen Wu. Methodology: Hang Yu, Xiangdong Liu. Resources: Xiangdong Liu. Supervision: Xiangdong Liu. Validation: Xiang Li, Yamin Jiao. Writing ? original draft: Xiang Li, Xiangdong Liu

Genome-Wide Analysis of Genetic Variations and the Detection of Rich Variants of NBS-LRR Encoding Genes in Common Wild Rice Lines

against rice blast and brown planthopper in two lines. The results will provide allele-specific markers for rice molecular breeding. Hang Yu and Muhammad Qasim Shahid contributed equally to this work

Two-Type Information Fusion Based IP-to-AS Mapping Table Refining

the refined mapping table, and comparing it with the AS topology driven by the original mapping table, which will show the advantage and necessity of refining the IP-to-AS mapping table. Hang-Yu Hu is

Genome wide re-sequencing of newly developed Rice Lines from common wild rice (Oryza rufipogon Griff.) for the identification of NBS-LRR genes

Common wild rice (Oryza rufipogon Griff.) is an important germplasm for rice breeding, which contains many resistance genes. Re-sequencing provides an unprecedented opportunity to explore the abundant useful genes at whole genome level. Here, we identified the nucleotide-binding site leucine-rich repeat (NBS-LRR) encoding genes by re-sequencing of two wild rice lines (i.e. Huaye...

Perfect Spin-filtering in graphene monolayer-bilayer superlattice with zigzag boundaries

We show that the spontaneous magnetization is formed at the zigzag boundary between monolayer and bilayer graphene by the self-consistent calculation based on Hubbard model. In a monolayer- bilayer graphene superlattice with zigzag boundaries, it is surprising that nearly 100% spin polarization is achieved in the energy window around the Dirac point, no matter the magnetization...

Aberrant SSEA-4 upregulation mediates myofibroblast activity to promote pre-cancerous oral submucous fibrosis

Oral submucous fibrosis (OSF), regarded as a precancerous condition, is characterized by juxta-epithelial inflammatory reaction followed by fibro-elastic change in the lamina properia and epithelial atrophy. The pathologic mechanisms of OSF still need to be further clarified. In the study, we investigated the functional expression of SSEA-4, which is a well-known stemness marker...

Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17/Treg balance in AMPK-dependent mechanisms

Pioglitazone (PIO), a thiazolidinediones drug, is a well-known anti-diabetic medicine, but its anti-atherosclerotic effects remain controversial. Thus it is important to investigate the effects of PIO on atherogenesis and the relevant mechanisms. For in vitro studies, primary cultured or AMP-activated protein kinase (AMPK) inhibited splenocytes were treated with oxidized low...

Millimeter-Wave Microstrip Antenna Array Design and an Adaptive Algorithm for Future 5G Wireless Communication Systems

This paper presents a high gain millimeter-wave (mmW) low-temperature cofired ceramic (LTCC) microstrip antenna array with a compact, simple, and low-profile structure. Incorporating minimum mean square error (MMSE) adaptive algorithms with the proposed 64-element microstrip antenna array, the numerical investigation reveals substantial improvements in interference reduction. A...

A novel signature for stratifying the molecular heterogeneity of the tissue-infiltrating T-cell receptor repertoire reflects gastric cancer prognosis

Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaJieyao Cheng, Xue Xu, Ming Zu, Jianfang Cui, Hang Yu & Aiming Yang AuthorsSearch for ... Search for Hang Yu in:Nature Research journals • PubMed • Google Scholar Search for Kaitai Zhang in:Nature Research journals • PubMed • Google Scholar Search for Aiming Yang in:Nature Research journals

Photodynamic Therapy with 5-Aminolevulinic acid (ALA) Impairs Tumor Initiating and Chemo-Resistance Property in Head and Neck Cancer-Derived Cancer Stem Cells

Background Head and neck cancer (HNC) ranks the fourth leading malignancy and cancer death in male population in Taiwan. Despite recent therapeutic advances, the prognosis for HNC patients is still dismal. New strategies are urgently needed to improve the chemosensitization to conventional chemotherapeutic drugs and clinical responses of HNC patients. Studies have demonstrated...

Membrane Sculpting by F-BAR Domains Studied by Molecular Dynamics Simulations

Interplay between cellular membranes and their peripheral proteins drives many processes in eukaryotic cells. Proteins of the Bin/Amphiphysin/Rvs (BAR) domain family, in particular, play a role in cellular morphogenesis, for example curving planar membranes into tubular membranes. However, it is still unclear how F-BAR domain proteins act on membranes. Electron microscopy...

Targeted exome sequencing reveals novel USH2A mutations in Chinese patients with simplex Usher syndrome

Background Usher syndrome (USH) is an autosomal recessive disorder characterized by hearing impairment and vision dysfunction due to retinitis pigmentosa. Phenotypic and genetic heterogeneities of this disease make it impractical to obtain a genetic diagnosis by conventional Sanger sequencing. Methods In this study, we applied a next-generation sequencing approach to detect...

Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein

ScholarSearch for Carlos B. Rueda in:Nature Research journals • PubMed • Google ScholarSearch for Hang Yu in:Nature Research journals • PubMed • Google ScholarSearch for David N. Thibodeaux in:Nature Research

Facile one-pot synthesis of flower-like AgCl microstructures and enhancing of visible light photocatalysis

Flower-like AgCl microstructures with enhanced visible light-driven photocatalysis are synthesized by a facile one-pot hydrothermal process for the first time. The evolution process of AgCl from dendritic structures to flower-like octagonal microstructures is investigated quantitatively. Furthermore, the flower-like AgCl microstructures exhibit enhanced ability of visible light...

Evidence-based green algal genomics reveals marine diversity and ancestral characteristics of land plants

Background Prasinophytes are widespread marine green algae that are related to plants. Cellular abundance of the prasinophyte Micromonas has reportedly increased in the Arctic due to climate-induced changes. Thus, studies of these unicellular eukaryotes are important for marine ecology and for understanding Viridiplantae evolution and diversification. Results We generated...

Oct4 Mediates Tumor Initiating Properties in Oral Squamous Cell Carcinomas through the Regulation of Epithelial-Mesenchymal Transition

Background Overexpression of Oct4, an important transcription factor of embryonic stem cells (ESC), has been reported in several cancers. The aim of this study was to determine the emerging role of Oct4 in oral squamous cell carcinoma (OSCC) both in vitro and in vivo. Methodology/Principal Finding Tumourigenic activity and molecular mechanisms of Oct4 overexpression or knockdown...

Computational Fluid Dynamics Study of Bifurcation Aneurysms Treated with Pipeline Embolization Device: Side Branch Diameter Study

An intracranial aneurysm, abnormal swelling of the cerebral artery, may lead to undesirable rates of mortality and morbidity upon rupture. Endovascular treatment involves the deployment of a flow-diverting stent that covers the aneurysm orifice, thereby reducing the blood flow into the aneurysm and mitigating the risk of rupture. In this study, computational fluid dynamics...

Simultaneous quantification of major bioactive constituents from Zhuyeqing Liquor by HPLC-PDA

Background Zhuyeqing Liquor (ZYQL) is a famous traditional Chinese functional liquor. For quality control of ZYQL products, quantitative analysis using high-performance liquid chromatography coupled with photodiode array detector (HPLC-PDA) was undertaken. Methods Eighteen compounds from ZYQL were simultaneously detected and used as chemical markers in the quantitative analysis...