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FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations

AffiliationsDepartment of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, GermanyJanine Diehl-Schmid, Abigail Licata, Oliver Goldhardt, Hans Förstl, Lina Riedl, Carola Roßmeier & Timo ... Scholar Search for Oliver Goldhardt in:Nature Research journals • PubMed • Google Scholar Search for Hans Förstl in:Nature Research journals • PubMed • Google Scholar Search for Igor Yakushew in:Nature

Predicting dementia in primary care patients with a cardiovascular health metric: a prospective population-based study

Background Improving cardiovascular health possibly decreases the risk of dementia. Primary care practices offer a suitable setting for monitoring and controlling cardiovascular risk factors in the older population. The purpose of the study is to examine the association of a cardiovascular health metric including six behaviors and blood parameters with the risk of dementia in...

Age-Correction of Test Scores Reduces the Validity of Mild Cognitive Impairment in Predicting Progression to Dementia

Objectives A phase of mild cognitive impairment (MCI) precedes most forms of neurodegenerative dementia. Many definitions of MCI recommend the use of test norms to diagnose cognitive impairment. It is, however, unclear whether the use of norms actually improves the detection of individuals at risk of dementia. Therefore, the effects of age- and education-norms on the validity of...

Cerebrospinal fluid biomarkers for Alzheimer’s disease: the role of apolipoprotein E genotype, age, and sex

Grimmer,2 Alexander Kurz,2 Hans Förstl,2 Horst Bickel,2 Janine Diehl-Schmid2 1Department of Neurology, University Hospital “Alexandrovska”, Sofia, Bulgaria; 2Department of Psychiatry, Technische Universität

Gaps Between Aims and Achievements in Therapeutic Modification of Neuronal Damage (“Neuroprotection”)

The term “neuroprotection” is often misused, overused, or misunderstood. A reasonable definition of neuroprotection refers to the preservation of “neuronal structure and/or function.” Although our knowledge about the cellular and molecular mechanisms of neurodegeneration has expanded, experimental systems and animal models that mimic the process or allow translation into clinical...

Frontotemporal lobar degeneration: current perspectives

Frontotemporal lobar degeneration: current perspectives Lina Riedl,1 Ian R Mackenzie,2 Hans Förstl,1 Alexander Kurz,1 Janine Diehl-Schmid1 1Center for Cognitive Disorders, Department of Psychiatry

Additive scales in degenerative disease - calculation of effect sizes and clinical judgment

Background The therapeutic efficacy of an intervention is often assessed in clinical trials by scales measuring multiple diverse activities that are added to produce a cumulative global score. Medical communities and health care systems subsequently use these data to calculate pooled effect sizes to compare treatments. This is done because major doubt has been cast over the...

Depressive Symptoms and the Risk of Ischemic Stroke in the Elderly—Influence of Age and Sex

Although a relationship between depression and cardiovascular events has been suggested, past study results regarding the risk of stroke in relation to depression by subgroups are ambiguous. The aim of this study was to investigate the influence of depressive symptoms on risk of incident ischemic stroke in elderly according to age and sex. This prospective cohort study followed...

Chronic kidney disease is associated with incident cognitive impairment in the elderly: the INVADE study

Background. Limited data exist regarding the relationship between decreased renal function and cognitive impairment. Methods. A total of 3679 participants of the Intervention Project on Cerebrovascular Diseases and Dementia in the Community of Ebersberg (INVADE) composed the community-based cohort study. Measures of renal function were estimated using the Cockcroft–Gault equation...

Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease

 Hans Förstl,1 Christian Sorg,1 Alexander Kurz,1 Alexander Drzezga,2 and Robert Perneczky1 1Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München

Quality of Life as an outcome in Alzheimer's disease and other dementias- obstacles and goals

Background The number of individuals at risk for dementia will probably increase in ageing societies as will the array of preventive and therapeutic options, both however within limited economic resources. For economic and medical purposes valid instruments are required to assess disease processes and the efficacy of therapeutic interventions for different forms and stages of...

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease

A number of susceptibility loci for Alzheimer's disease (AD) have been identified including a region on Chromosome 10q21–q22. Within this region the plasminogen activator urokinase gene (PLAU) was considered as a reasonable candidate from its functional implication in plasmin generation, a serine protease capable of degrading beta-Amyloid (Aβ) protein. We screened 56 single...