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Therapie der akuten diabetischen Stoffwechselentgleisungen bei Erwachsenen (Update 2019)

ZusammenfassungAkute Stoffwechselentgleisungen können für Erwachsene in Abhängigkeit von ihrem Ausmaß lebensbedrohlich sein. Dementsprechend sind eine rasche umfassende Diagnostik und Therapie sowie eine enge Überwachung der Vitalparameter und Laborbefunde erforderlich. Bei der Therapie, die sich bei der ketoazidotischen (DKA) und hyperglykämisch-hyperosmolaren (HHS) Form nicht...

Diabetesmanagement im Krankenhaus (Update 2019)

ZusammenfassungDieses Positionspapier beinhaltet die Empfehlungen der Österreichischen Diabetes Gesellschaft zum Management von erwachsenen Patienten mit Diabetes mellitus während stationärer Aufenthalte und basiert auf aktueller Evidenz zu Blutglukosezielbereichen, Insulintherapie und Therapie mit oralen Antidiabetika während stationärer Aufenthalte. Zusätzlich werden...

Andere spezifische Diabetesformen und exokrine Pankreasinsuffizienz (Update 2019)

ZusammenfassungDie unter der Kategorie „andere spezifische Diabetesformen“ zusammengefassten Störungen des Glukosestoffwechsels stellen pathophysiologisch und therapeutisch eine sehr heterogene Krankheitsgruppe dar. Umfasst werden Diabetesformen, die im Rahmen von anderen endokrinologischen Erkrankungen auftreten (z. B. Akromegalie, Cushing-Syndrom), pankreoprive Formen (z. B...

Diabetische Nierenerkrankung (Update 2019)

ZusammenfassungRezente epidemiologische Untersuchungen zeigen, dass etwa 2–3 % aller Österreicher Diabetes mit Nierenbeteiligung aufweisen. Diese betrifft somit in Österreich etwa 250.000 Menschen. Das Risiko des Auftretens und Fortschreitens der Erkrankung kann durch Lebensstilinterventionen und Optimierung der Einstellung des Blutdrucks, Blutzuckers und spezielle...

Antihyperglykämische Therapie bei Diabetes mellitus Typ 2 (Update 2019)

ZusammenfassungDie Hyperglykämie ist wesentlich an der Entstehung der Spätkomplikationen bei an Diabetes mellitus Typ 2 erkrankten Patienten/Patientinnen beteiligt. Während Lebensstilmaßnahmen die Eckpfeiler jeder Diabetestherapie bleiben, benötigen im Verlauf die meisten Patienten/Patientinnen mit Typ 2 Diabetes eine medikamentöse Therapie. Bei der Definition individueller...

Intermittent Fasting (Alternate Day Fasting) in Healthy, Non-obese Adults: Protocol for a Cohort Trial with an Embedded Randomized Controlled Pilot Trial

the work as a whole and have given their approval for this version to be published. Authorship Contributions. Harald Sourij, Norbert J. Tripolt, Slaven Stekovic, Sabrina Schro¨der, Frank Madeo ... Harald Sourij wrote the clinical protocol and obtained authorization from the Ethics Committee and wrote the manuscript. Albrecht Schmidt, Ewald Kolesnik, Nicolas Verheyen performed and evaluated the

The effects of linagliptin on endothelial function and global arginine bioavailability ratio in coronary artery disease patients with early diabetes: study protocol for a randomized controlled trial

Background Patients with type 2 diabetes (T2DM) are at increased risk for macrovascular events as well as for microvascular complications. There is evidence that in patients with coronary artery disease (CAD), about 35 % suffer from manifest T2DM. Early glucose-lowering intervention in subjects with T2DM has been demonstrated to be beneficial in terms of cardiovascular risk...

An Untargeted Metabolomics Approach to Characterize Short-Term and Long-Term Metabolic Changes after Bariatric Surgery

Bariatric surgery is currently one of the most effective treatments for obesity and leads to significant weight reduction, improved cardiovascular risk factors and overall survival in treated patients. To date, most studies focused on short-term effects of bariatric surgery on the metabolic profile and found high variation in the individual responses to surgery. The aim of this...

Diabetische Nierenerkrankung – Update 2016

2 Harald Sourij · Roland Edlinger · Friedrich Prischl · Martin Auinger · Alexandra Kautzky-Willer · Marcus D. Säemann · Rudolf Prager · Martin Clodi · Guntram Schernthaner · Gert Mayer · Rainer

Increased DNA Dicarbonyl Glycation and Oxidation Markers in Patients with Type 2 Diabetes and Link to Diabetic Nephropathy

Fuchs,2 Harald Sourij,4 Naila Rabbani,1,5 and Paul J. Thornalley1,5 1Warwick Medical School, Clinical Sciences Research Laboratories, University of Warwick, University Hospital, Coventry CV2 2DX, UK ... M. Winklhofer-Roob, Johannes M. Roob, Sebastian Fuchs, and Harald Sourij performed subject recruitment and sample collection, Brigitte M. Winklhofer-Roob also edited the paper, and Naila Rabbani and

Multiple risk factor intervention reduces carotid atherosclerosis in patients with type 2 diabetes

Background Patients with rapid progression of carotid intima media thickness (CIMT) were shown to have a higher future risk for cardiovascular events. The aim of this study was to investigate the impact of multiple risk factor intervention on CIMT progression and to establish whether new cardiovascular surrogate measurements would allow prediction of CIMT changes. Materials and...

Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study

Metabolic syndrome is associated with disturbances in gut microbiota composition. We aimed to investigate the effect of Lactobacillus casei Shirota (LcS) on gut microbiota composition, gut barrier integrity, intestinal inflammation and serum bile acid profile in metabolic syndrome. In a single-centre, prospective, randomised controlled pilot study, 28 subjects with metabolic...

Evaluation of a Self-Administered Oral Glucose Tolerance Test

OBJECTIVE To assess the feasibility of using a disposable, self-administered, capillary blood sampling oral glucose tolerance test (OGTT) device in a community setting.

Effects of Pioglitazone on Endothelial Function, Insulin Sensitivity, and Glucose Control in Subjects With Coronary Artery Disease and New-Onset Type 2 Diabetes

OBJECTIVE—About one of five patients with coronary artery disease (CAD) suffers from previously unknown, predominantly postprandial type 2 diabetes. In the process of atherogenesis and the subsequent increased cardiovascular mortality of diabetic patients, endothelial dysfunction is suspected to play an important role, and it is observed in diabetic as well as insulin-resistant...

Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study

Introduction Vitamin D deficiency is encountered frequently in critically ill patients and might be harmful. Current nutrition guidelines recommend very low vitamin D doses. The objective of this trial was to evaluate the safety and efficacy of a single oral high-dose vitamin D3 supplementation in an intensive care setting over a one-week observation period. Methods This was a...

Efficacy of a Continuous GLP-1 Infusion Compared With a Structured Insulin Infusion Protocol to Reach Normoglycemia in Nonfasted Type 2 Diabetic Patients: A Clinical Pilot Trial

HARALD SOURIJ ISABELLA SCHM OLZER EVA KETTLER-SCHMUT MICHAELA EDER HELGA PRESSL ANTONELLA DECAMPO THOMAS C. WASCHER OBJECTIVE - Continuously administered insulin is limited by the need for frequent

Multicentric Validation of Proteomic Biomarkers in Urine Specific for Diabetic Nephropathy

Johannes M. Roob Kasper Rossing Peter Rossing Ivan Rychlk Harald Sourij Beate Tiran Brigitte M. Winklhofer-Roob Gerjan J. Navis for the PREDICTIONS Group" Massimo Federici, University of Tor Vergata, Italy