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Bone marrow-derived CXCR4-overexpressing MSCs display increased homing to intestine and ameliorate colitis-associated tumorigenesis in mice

Increasing interest has developed in the therapeutic potential of bone marrow-derived mesenchymal stem cells (MSCs) for the treatment of inflammatory bowel disease (IBD) and IBD-induced cancer. However, whether MSCs have the ability to suppress or promote tumor development remains controversial. The stromal cell-derived factor 1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4...

Discovery and validation of DNA methylation markers for overall survival prognosis in patients with thymic epithelial tumors

BackgroundThe current prognosis of thymic epithelial tumors (TETs) is according to the World Health Organization (WHO) histologic classification and the Masaoka staging system. These methods of prognosis have certain limitations in clinical application and there is a need to seek new method for determining the prognosis of patients with TETs. To date, there have been no studies...

TVT versus TOT in the treatment of female stress urinary incontinence: a systematic review and meta-analysis

TVT versus TOT in the treatment of female stress urinary incontinence: a systematic review and meta-analysis Zhong-Ming Huang, He Xiao, Zhi-Gang Ji, Wei-Gang Yan, Yan-Sheng Zhang Department of

Male gender is associated with an increased risk of anastomotic leak in rectal cancer patients after total mesorectal excision

The impact of a patient’s gender on the development of anastomotic leak (AL) in rectal cancer patients following total mesorectal excision (TME) remains controversial. The aim of this study was to evaluate the association between patients’ gender and the risk of AL.

Enteral nutrition is associated with a decreased risk of surgical intervention in Crohn's disease patients with spontaneous intra-abdominal abscess

Background: The impact of enteral nutrition (EN) on surgical risk in Crohn's disease (CD) patients suffering from spontaneous intra-abdominal abscess (IAA) was evaluated. Methods: CD patients diagnosed with spontaneous IAA from 2008 to 2015 were included in the study. The impact of EN on surgical risk was evaluated using both univariate and multivariate analyses. Results: A total...

A systems pharmacology-oriented discovery of a new therapeutic use of the TCM formula Liuweiwuling for liver failure

Zhao-fang Bai Gen-hua Xu Peng-yan Li Wen-yan Jiang Jing-jing Han Xiao Ma Guang-ming Cai Rui-sheng Li Li-ping Zhang Xiao-he Xiao OPEN Multiple components of traditional Chinese medicine (TCM) formulae

G9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner

Foundation for PhD, Affiliated Hospital of Jining Medical University (No. 2016-BS-006). Author information Author notes These authors contributed equally: Lei Hu, Ming-de Zang, He-xiao Wang. Edited by Y ... , Shanghai, People’s Republic of ChinaLei Hu, Ming-de Zang, He-xiao Wang, Zhen-qiang Wang, Zhi-yuan Fan, Huo Wu, Jian-fang Li, Li-ping Su, Min Yan, Qiu-meng Yang, Bing-ya Liu & Zheng-gang ZhuDepartment of

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database Jing Wang,1,* Chunxia Qiao,1,* He Xiao,1 Zhou Lin,1 Yan Li,1 Jiyan Zhang

An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer

Ding Renxi Wang He Xiao Chunmei Hou Beifen Shen Jiannan Feng Renfeng Guo Yan Li Hui Peng Gencheng Guojiang Chen OPEN Growing evidence shows that granulocyte macrophage colony-stimulating factor (GM-CSF

Flame Retardation Modification of Paper-Based PVC Wallcoverings

The flame-retarded paper-based polyvinyl chloride (PVC) wallcoverings were successfully prepared, using plant fiber paper as base material and adding inorganic flame retardants and flame-retarded plasticizer as additives. Flame retardancy, thermostability, smoke suppression and mechanical properties were tested regarding to the prepared wallcoverings. The results showed that 2ZnO...

Identification of a Novel Allele of TaCKX6a02 Associated with Grain Size, Filling Rate and Weight of Common Wheat

Cytokinin oxidase (CKX) plays a crucial role in plant growth and development by reversibly inactivating cytokinin (CTK). Twenty-four primer pairs, designed from ESTs of the TaCKX genes family of common wheat, were used to identify their allelic variations associated with grain size, weight, and filling rate in 169 recombinant inbred lines (RIL) derived from Jing 411...

Quality Assessment of Panax notoginseng from Different Regions through the Analysis of Marker Chemicals, Biological Potency and Ecological Factors

Panax notoginseng (Burk.) F.H. Chen, called Sanqi in China, is a perennial herb that has been used as a medicinal herb in traditional Chinese medicine for more than 400 years. Because notoginseng is included in many proprietary Chinese medicines, the quality of notoginseng directly affects its efficacy and safety. However, considering the complex and special growth environment...

Efficacy of Compound Kushen Injection in Relieving Cancer-Related Pain: A Systematic Review and Meta-Analysis

Despite widespread popular use of complementary and alternative medicine (CAM) therapies, a rigorous evidence based on the efficacy of compound kushen injection (CKI) for cancer-related pain is lacking. In this study, we evaluated the efficacy and safety of compound kushen injection and provided information for current or future research and clinical application. Sixteen trials...

Efficacy of Compound Kushen Injection in Relieving Cancer-Related Pain: A Systematic Review and Meta-Analysis

Despite widespread popular use of complementary and alternative medicine (CAM) therapies, a rigorous evidence based on the efficacy of compound kushen injection (CKI) for cancer-related pain is lacking. In this study, we evaluated the efficacy and safety of compound kushen injection and provided information for current or future research and clinical application. Sixteen trials...

Green tea polyphenol, epigallocatechin-3-gallate, possesses the antiviral activity necessary to fight against the hepatitis B virus replication in vitro

low toxicity and providing different anti-HBV activity as compared with 3TC. Compliance with ethics guidelines Jing-yao PANG, Kui-jun ZHAO, Jia-bo WANG, Zhi-jie MA, and Xiao-he XIAO declare that they

Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. Currently, there are no recognized medical therapies effective for NAFLD. Previous studies have demonstrated the effects of total turmeric extract on rats with NAFLD induced by high-fat diet. In this study, serum metabolomics was employed using UHPLC-Q-TOF-MS to elucidate the...

Association between the XRCC1 Arg399Gln Polymorphism and Risk of Cancer: Evidence from 297 Case–Control Studies

Background The Arg399Gln polymorphism in the X-ray cross-complementing group 1 (XRCC1) had been implicated in cancer susceptibility. The previous published data on the association between XRCC1 Arg399Gln polymorphism and cancer risk remained controversial. Methodology/Principal Findings To derive a more precise estimation of the association between the XRCC1 Arg399Gln...