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Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension

). Author Contributions Conceptualization: Hideaki Suzuki, Paul M. Matthews. Data curation: Hideaki Suzuki, He Gao, Wenjia Bai, Paul M. Matthews. Formal analysis: Hideaki Suzuki, He Gao, Evangelos ... Evangelou. Funding acquisition: Hideaki Suzuki, Declan P. O'Regan, Paul Elliott, Paul M. Matthews. Investigation: Hideaki Suzuki, Wenjia Bai. Methodology: Hideaki Suzuki, He Gao, Wenjia Bai, Evangelos

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel...