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Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension

). Author Contributions Conceptualization: Hideaki Suzuki, Paul M. Matthews. Data curation: Hideaki Suzuki, He Gao, Wenjia Bai, Paul M. Matthews. Formal analysis: Hideaki Suzuki, He Gao, Evangelos ... Evangelou. Funding acquisition: Hideaki Suzuki, Declan P. O'Regan, Paul Elliott, Paul M. Matthews. Investigation: Hideaki Suzuki, Wenjia Bai. Methodology: Hideaki Suzuki, He Gao, Wenjia Bai, Evangelos

Antimicrobial Properties and Membrane-Active Mechanism of a Potential α-Helical Antimicrobial Derived from Cathelicidin PMAP-36

Antimicrobial peptides (AMPs), which present in the non-specific immune system of organism, are amongst the most promising candidates for the development of novel antimicrobials. The modification of naturally occurring AMPs based on their residue composition and distribution is a simple and effective strategy for optimization of known AMPs. In this study, a series of truncated...

Phosphatidylserine Synthase Controls Cell Elongation Especially in the Uppermost Internode in Rice by Regulation of Exocytosis

The uppermost internode is one of the fastest elongating organs in rice, and is expected to require an adequate supply of cell-wall materials and enzymes to the cell surface to enhance mechanical strength. Although it has been reported that the phenotype of shortened uppermost internode 1 (sui1) is caused by mutations in PHOSPHATIDYLSERINE SYNTHASE (OsPSS), the underlying...

Fur Is a Repressor of Biofilm Formation in Yersinia pestis

Background Yersinia pestis synthesizes the attached biofilms in the flea proventriculus, which is important for the transmission of this pathogen by fleas. The hmsHFRS operons is responsible for the synthesis of exopolysaccharide (the major component of biofilm matrix), which is activated by the signaling molecule 3′, 5′-cyclic diguanylic acid (c-di-GMP) synthesized by the only...

Systematic Review of Anastomotic Leakage Rate According to an International Grading System Following Anterior Resection for Rectal Cancer

BackgroundA generally acceptable definition and a severity grading system for anastomotic leakages (ALs) following rectal resection were not available until 2010, when the International Study Group of Rectal Cancer (ISGRC) proposed a definition and a grading system for AL. MethodsA search for published data was performed using the MEDLINE database (2000 to December 5, 2012) to...

Molecular Characterization of Transcriptional Regulation of rovA by PhoP and RovA in Yersinia pestis

Background Yersinia pestis is the causative agent of plague. The two transcriptional regulators, PhoP and RovA, are required for the virulence of Y. pestis through the regulation of various virulence-associated loci. They are the global regulators controlling two distinct large complexes of cellular pathways. Methodology/Principal Findings Based on the LacZ fusion, primer...