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Reverse Shock Emission in Gamma-Ray Bursts Revisited

Copyright © 2015 He Gao and Peter Mészáros. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any

Identification and characterization of PhoP regulon members in Yersinia pestis biovar Microtus

Background The transcription regulator PhoP has been shown to be important for Y. pestis survival in macrophages and under various in vitro stresses. However, the mechanism by which PhoP promotes bacterial intracellular survival is not fully understood. Our previous microarray analysis suggested that PhoP governed a wide set of cellular pathways in Y. pestis. A series of...

Treatment variation in patients diagnosed with early stage breast cancer in Alberta from 2002 to 2010: a population-based study

Background Breast-conserving surgery (BCS) followed by radiotherapy is generally the preferred treatment for women diagnosed with early stage breast cancer. This study aimed to investigate the proportion of patients who receive BCS versus mastectomy and post-BCS radiotherapy, and explore factors associated with receipt of these treatments in Alberta, Canada. Methods A...

Phenotypic and transcriptional analysis of the osmotic regulator OmpR in Yersinia pestis

Background The osmotic regulator OmpR in Escherichia coli regulates differentially the expression of major porin proteins OmpF and OmpC. In Yersinia enterocolitica and Y. pseudotuberculosis, OmpR is required for both virulence and survival within macrophages. However, the phenotypic and regulatory roles of OmpR in Y. pestis are not yet fully understood. Results Y. pestis OmpR is...

Regulatory effects of cAMP receptor protein (CRP) on porin genes and its own gene in Yersinia pestis

Background The cAMP receptor protein (CRP) is a global bacterial regulator that controls many target genes. The CRP-cAMP complex regulates the ompR-envZ operon in E. coli directly, involving both positive and negative regulations of multiple target promoters; further, it controls the production of porins indirectly through its direct action on ompR-envZ. Auto-regulation of CRP...

Characterization of Zur-dependent genes and direct Zur targets in Yersinia pestis

Background The zinc uptake regulator Zur is a Zn2+-sensing metalloregulatory protein involved in the maintenance of bacterial zinc homeostasis. Up to now, regulation of zinc homeostasis by Zur is poorly understood in Y. pestis. Results We constructed a zur null mutant of Y. pestis biovar microtus strain 201. Microarray expression analysis disclosed a set of 154 Zur-dependent...

Direct and negative regulation of the sycO-ypkA-ypoJ operon by cyclic AMP receptor protein (CRP) in Yersinia pestis

Background Pathogenic yersiniae, including Y. pestis, share a type III secretion system (T3SS) that is composed of a secretion machinery, a set of translocation proteins, a control system, and six Yop effector proteins including YpkA and YopJ. The cyclic AMP receptor protein (CRP), a global regulator, was recently found to regulate the laterally acquired genes (pla and pst) in Y...

Design and Dynamic Model of a Frog-inspired Swimming Robot Powered by Pneumatic Muscles

interests include mechanical design and bionic robotics. E-mail: Peng-Cheng Kong, born in 1992, received his master degree from Harbin Institute of Technology, China , in 2016 . E-mail: He-Gao Cai, is

Inhalation of Nitric Oxide in the Treatment of Severe Acute Respiratory Syndrome: A Rescue Trial in Beijing

Inhalation of nitric oxide (NO) improved arterial oxygenation and enabled the reduction of inspired oxygen therapy and airway pressure support in patients with severe acute respiratory syndrome (SARS). In addition, chest radiography showed decreased spread or density of lung infiltrates, and the physiological effects remained after termination of inhaled NO therapy. These...

Genetic Variation in CDH13 Is Associated With Lower Plasma Adiponectin Levels but Greater Adiponectin Sensitivity in East Asian Populations

He Gao Yu-Mi Kim Peng Chen Michiya Igase Ryuichi Kawamoto Mi Kyung Kim Katsuhiko Kohara Jeannette Lee Tetsuro Miki Rick Twee-Hee Ong Hiroshi Onuma Haruhiko Osawa Xueling Sim Yik Ying Teo Yasuharu

Evidence of a Causal Relationship Between Adiponectin Levels and Insulin Sensitivity: A Mendelian Randomization Study

He Gao Tove Fall Rob M. van Dam Allan Flyvbjerg Bjrn Zethelius Erik Ingelsson Sara Hgg The adipocyte-secreted protein adiponectin is associated with insulin sensitivity in observational studies. We

A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2

Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we...

Uptake and Tolerance of Chemotherapy in Elderly Patients with Small Cell Lung Cancer and Impact on Survival

The treatment of elderly cancer patients is complicated by many factors. We sought to assess the uptake and tolerance of chemotherapy among patients 75 years and older diagnosed with small cell lung cancer (SCLC) in years 2004–2008 in Alberta, Canada, and assess their survival. All patients who met the above criteria and had an oncologist-consult were included. Data were obtained...

Uptake and Tolerance of Chemotherapy in Elderly Patients with Small Cell Lung Cancer and Impact on Survival

The treatment of elderly cancer patients is complicated by many factors. We sought to assess the uptake and tolerance of chemotherapy among patients 75 years and older diagnosed with small cell lung cancer (SCLC) in years 2004–2008 in Alberta, Canada, and assess their survival. All patients who met the above criteria and had an oncologist-consult were included. Data were obtained...

Modified Maag’s Spherical Diffusion Model of Vacuum Penetration Grouting

The penetration grouting is very widely used in geotechnical engineering nowadays, but the slurry diffusion radius is not long enough because of low grouting pressure. The vacuum grouting method is proposed to solve this problem. However, there is no diffusion theory model of vacuum grouting, which makes the practical application lack scientific basis. In this paper, the...

Compton scattering of self-absorbed synchrotron emission

Synchrotron self-Compton (SSC) scattering is an important emission mechanism in many astronomical sources, such as gamma-ray bursts (GRBs) and active galactic nuclei. We give a complete presentation of the analytical approximations for the Compton scattering of synchrotron emission with both weak and strong synchrotron self-absorption. All possible orders of the characteristic...

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel...

Ehd4 Encodes a Novel and Oryza-Genus-Specific Regulator of Photoperiodic Flowering in Rice

Land plants have evolved increasingly complex regulatory modes of their flowering time (or heading date in crops). Rice (Oryza sativa L.) is a short-day plant that flowers more rapidly in short-day but delays under long-day conditions. Previous studies have shown that the CO-FT module initially identified in long-day plants (Arabidopsis) is evolutionary conserved in short-day...

Characterisation of a Plancitoxin-1-Like DNase II Gene in Trichinella spiralis

Background Deoxyribonuclease II (DNase II) is a well-known acidic endonuclease that catalyses the degradation of DNA into oligonucleotides. Only one or a few genes encoding DNase II have been observed in the genomes of many species. 125 DNase II-like protein family genes were predicted in the Trichinella spiralis (T. spiralis) genome; however, none have been confirmed. DNase II...

Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension

). Author Contributions Conceptualization: Hideaki Suzuki, Paul M. Matthews. Data curation: Hideaki Suzuki, He Gao, Wenjia Bai, Paul M. Matthews. Formal analysis: Hideaki Suzuki, He Gao, Evangelos ... Evangelou. Funding acquisition: Hideaki Suzuki, Declan P. O'Regan, Paul Elliott, Paul M. Matthews. Investigation: Hideaki Suzuki, Wenjia Bai. Methodology: Hideaki Suzuki, He Gao, Wenjia Bai, Evangelos