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Altered Crossover Distribution and Frequency in Spermatocytes of Infertile Men with Azoospermia

During meiosis, homologous chromosomes pair to facilitate the exchange of DNA at crossover sites along the chromosomes. The frequency and distribution of crossover formation are tightly regulated to ensure the proper progression of meiosis. Using immunofluorescence techniques, our group and others have studied the meiotic proteins in spermatocytes of infertile men, showing that...

Exploring the Molecular Mechanism and Biomakers of Liver Cancer Based on Gene Expression Microarray

Liver cancer is one of the most common cancers worldwide with high morbidity and mortality. Its molecular mechanism hasn’t been fully understood though many studies have been conducted and thus further researches are still needed to improve the prognosis of liver cancer. Firstly, differentially expressed genes (DEGs) between six Mdr2-knockout (Mdr2-KO) mutant mice samples (3...

Corrigendum: Vesicle Size Regulates Nanotube Formation in the Cell

Scientiifc Reports Corrigendum: Vesicle size Regulates Nanotube Formation in the Cell Qian p eter su Wanqing Du Qinghua Ji Boxin Xue Dong Jiang Yueyao Zhu He Ren Chuanmao Zhang Jizhong Lou Yujie sun ... RepoRts He Ren and Chuanmao Zhang were omitted from the author list in the original version of this Article. This has been corrected in the PDF and HTML versions of the Article, as well as the

Automatic Multiple-Needle Surgical Planning of Robotic-Assisted Microwave Coagulation in Large Liver Tumor Therapy

The “robotic-assisted liver tumor coagulation therapy” (RALTCT) system is a promising candidate for large liver tumor treatment in terms of accuracy and speed. A prerequisite for effective therapy is accurate surgical planning. However, it is difficult for the surgeon to perform surgical planning manually due to the difficulties associated with robot-assisted large liver tumor...

Retraction Note to: The hypoxia-inducible factor-1 regulates the microRNA185 expression through binding to hypoxia response elements sequence 2

Zhenguo Song He Ren Song Gao Tiansuo Zhao Xiuchao Wang Shengjie Zhang Xiao Zhao Lingling Jia Junwei Sun Jihui Hao the knowledge of all authors and so the authors would like apology to the co-authors

Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression

Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaChongbiao Huang, Na Li, Zengxun Li, Tiansuo Zhao, Yang Li, Xiuchao Wang, He Ren & Jihui HaoSenior Ward ... for Shengyu Yang in:Nature Research journals • PubMed • Google ScholarSearch for He Ren in:Nature Research journals • PubMed • Google ScholarSearch for Jihui Hao in:Nature Research journals • PubMed

Nanospheres of doxorubicin as cross-linkers for a supramolecular hydrogelation

critical review of the manuscript. Author information Author notesQiang Xue & He Ren These authors contributed equally to this work. AffiliationsNational Clinical Research Center for Cancer, Key ... Laboratory of Cancer Prevention and Therapy, Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P. R. ChinaQiang Xue, He Ren, Chao Xu & Jihui HaoState Key

Vesicle Size Regulates Nanotube Formation in the Cell

• Google ScholarSearch for Dong Jiang in:Nature Research journals • PubMed • Google ScholarSearch for Yueyao Zhu in:Nature Research journals • PubMed • Google ScholarSearch for He Ren in:Nature Research

Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to Fyn

University of Toronto. He is currently investigating signaling downstream of oAβ. Carl He Ren is a Graduate student at the University of Toronto. He is studying the physiological role of the prion protein. Dr

SCF, Regulated by HIF-1α, Promotes Pancreatic Ductal Adenocarcinoma Cell Progression

Stem cell factor (SCF) and hypoxia-inducible factor-1α (HIF-1α) both have important functions in pancreatic ductal adenocarcinoma (PDAC). This study aims to analyze the expression and clinicopathological significance of SCF and HIF-1α in PDAC specimens and explore the molecular mechanism at PDAC cells in vitro and in vivo. We showed that the expression of SCF was significantly...

CypA, a Gene Downstream of HIF-1α, Promotes the Development of PDAC

Hypoxia-inducible factor-1α (HIF-1α) is a highly important transcription factor involved in cell metabolism. HIF-1α promotes glycolysis and inhibits of mitochondrial respiration in pancreatic ductal adenocarcinoma (PDAC). In response to tumor hypoxia, cyclophilin A (CypA) is over-expressed in various cancer types, and is associated with cell apoptosis, tumor invasion, metastasis...

Stem cell factor is a novel independent prognostic biomarker for hepatocellular carcinoma after curative resection

Stem cell factor (SCF), a ligand of c-kit, is a hematopoietic growth factor. Uncontrolled activity of SCF/c-kit signaling pathway contributes to the formation of a variety of human malignancies. In this study, we determined whether SCF expression could risk-stratify patients with hepatocellular carcinoma (HCC) after curative resection. HCC tissues from 160 patients were collected...

Regional Intra-Arterial vs. Systemic Chemotherapy for Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Objective To investigate the efficacy and safety of regional intra-arterial chemotherapy (RIAC) versus systemic chemotherapy for stage III/IV pancreatic cancer. Methods Randomized controlled trials of patients with advanced pancreatic cancer treated by regional intra-arterial or systemic chemotherapy were identified using PubMed, ISI, EMBASE, Cochrane Library, Google, Chinese...

Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β

University, Beijing 100871, ChinaQuanlong Lu, Zhigang Lu, Qinying Liu, Li Guo, He Ren, Jingyan Fu, Qing Jiang & Chuanmao ZhangDivision of Cancer Research, Jacqui Wood Cancer Centre, Ninewells Hospital and ... • PubMed • Google ScholarSearch for Qinying Liu in:Nature Research journals • PubMed • Google ScholarSearch for Li Guo in:Nature Research journals • PubMed • Google ScholarSearch for He Ren in:Nature

Hypoxia-Inducible Factor-1α Regulates Chemotactic Migration of Pancreatic Ductal Adenocarcinoma Cells through Directly Transactivating the CX3CR1 Gene

CX3CR1 is an important chemokine receptor and regulates the chemotactic migration of pancreatic ductal adenocarcinoma (PDAC) cells. Up to now, its regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulates the expression of CX3CR1 in pancreatic cancer cells. When hypoxia-inducible factor (HIF)-1α expression was knocked down in vitro and in vivo, the...

Hydrogen peroxide primes heart regeneration with a derepression mechanism

While the adult human heart has very limited regenerative potential, the adult zebrafish heart can fully regenerate after 20% ventricular resection. Although previous reports suggest that developmental signaling pathways such as FGF and PDGF are reused in adult heart regeneration, the underlying intracellular mechanisms remain largely unknown. Here we show that H2O2 acts as a...

Hypoxia-inducible factor (HIF)-1α directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)

Stem cell factor (SCF) plays important roles in tumor growth and angiogenesis. However, its regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulated the expression of SCF in MCF-7 breast cancer cells in both messenger RNA and protein levels. When hypoxia-inducible factor (HIF)-1α expression was knocked down by RNA interference, the MCF-7 cell...