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16 papers found.
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Synergistic actions of FGF2 and bone marrow transplantation mitigate radiation-induced intestinal injury

Unwanted radiological or nuclear exposure remains a public health risk for which effective therapeutic countermeasures are lacking. Here, we evaluated the efficacy of fibroblast growth factor-2 (FGF2) in treating radiation-induced gastrointestinal syndrome (RIGS) incurred by lethal whole-body irradiation (WBI) when administered in conjunction with bone marrow transplantation (BMT...

Usual gait speed is associated with frailty status, institutionalization, and mortality in community-dwelling rural older adults: a longitudinal analysis of the Aging Study of Pyeongchang Rural Area

Hee-Won Jung,1,2,* Il-Young Jang,3,4,* Chang Ki Lee,5 Sang Soo Yu,4 Jae Kyoon Hwang,4 Chawoong Jeon,4 Young Soo Lee,3 Eunju Lee3 1Graduate School of Medical Science and Engineering, Korea Advanced

Comparisons of predictive values of sarcopenia with different muscle mass indices in Korean rural older adults: a longitudinal analysis of the Aging Study of PyeongChang Rural Area

,* Hee-Won Jung,3,4,* Chang Ki Lee,5 Sang Soo Yu,2 Young Soo Lee,1 Eunju Lee1 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 2PyeongChang Health ... Dairies Co., Ltd. from the Asan Institute for Life Sciences and Corporate Relations of the Asan Medical Center, Seoul, Republic of Korea. Dr Hee-Won Jung was supported by a Global PhD Fellowship Program

Urologic symptoms and burden of frailty and geriatric conditions in older men: the Aging Study of PyeongChang Rural Area

Urologic symptoms and burden of frailty and geriatric conditions in older men: the Aging Study of PyeongChang Rural Area Il-Young Jang,1,2 Chang Ki Lee,3 Hee-Won Jung,4,5 Sang Soo Yu,2 Young Soo Lee ... have any role in the study design, data collection, analysis or interpretation of the data, writing of the paper, or decision to submit the paper for publication. Dr Hee-Won Jung is supported by a

A New Equation to Estimate Muscle Mass from Creatinine and Cystatin C

Background With evaluation for physical performance, measuring muscle mass is an important step in detecting sarcopenia. However, there are no methods to estimate muscle mass from blood sampling. Methods To develop a new equation to estimate total-body muscle mass with serum creatinine and cystatin C level, we designed a cross-sectional study with separate derivation and...

Fractionated Stereotactic Gamma Knife Radiosurgery for Large Brain Metastases: A Retrospective, Single Center Study

Purpose Stereotactic radiosurgery (SRS) is widely used for brain metastases but has been relatively contraindicated for large lesions (>3 cm). In the present study, we analyzed the efficacy and toxicity of hypofractionated Gamma Knife radiosurgery to treat metastatic brain tumors for which surgical resection were not considered as the primary treatment option. Methods and...

Multidimensional Geriatric Prognostic Index, Based on a Geriatric Assessment, for Long-Term Survival in Older Adults in Korea

The patient´s survival estimate is important for clinical decision-making, especially in frail patients with multimorbidities. We aimed to develop a multidimensional geriatric prognosis index (GPI) for 3- and 5-year mortality in community-dwelling elderly and to validate the GPI in a separate hospital-based population. The GPI was constructed using data for 988 participants in...

Prevalence and Outcomes of Frailty in Korean Elderly Population: Comparisons of a Multidimensional Frailty Index with Two Phenotype Models

Background Frailty is related to adverse outcomes in the elderly. However, current status and clinical significance of frailty have not been evaluated for the Korean elderly population. We aimed to investigate the usefulness of established frailty criteria for community-dwelling Korean elderly. We also tried to develop and validate a new frailty index based on a multidimensional...

A practical scoring system to determine whether to proceed with surgical resection in recurrent glioblastoma

Background To determine the benefit of surgical management in recurrent glioblastoma, we analyzed a series of patients with recurrent glioblastoma who had undergone surgery, and we devised a new scale to predict their survival.

Therapeutic efficacy and safety of TRAIL-producing human adipose tissue–derived mesenchymal stem cells against experimental brainstem glioma

Mesenchymal stem cells (MSCs) have an extensive migratory capacity for gliomas, which is comparable to that of neural stem cells. Among the various types of MSCs, human adipose tissue-derived MSCs (hAT-MSC) emerge as one of the most attractive vehicles for gene therapy because of their high throughput, lack of ethical concerns, and availability and ease of isolation. We evaluated...

Recursive partitioning analysis of prognostic factors in WHO grade III glioma patients treated with radiotherapy or radiotherapy plus chemotherapy

Background We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the results of RPA specifically for WHO grade III gliomas. Methods A total of 133 patients with anaplastic astrocytoma (AA, n = 56), anaplastic oligodendroglioma (AO, n...

Usefulness of MS-MLPA for detection of MGMT promoter methylation in the evaluation of pseudoprogression in glioblastoma patients

Pseudoprogression is a major diagnostic dilemma in current treatment protocols for malignant gliomas that involve concurrent chemoradiotherapy. We hypothesized that methylation-specific multiplex ligation probe amplification (MS-MLPA), an assay that permits semiquantitative evaluation of promoter methylation, may be used to diagnose pseudoprogression based on the quantification...

NEUROSURGICAL TREATMENTS

Patients with cancer are at high risk of developing venous thromboembolism (VTE). The purpose of this study was to review VTE development in patients undergoing craniotomy for a neoplasm, and to further analyze risk based on multiple pre-, intra-, and post-operative variables. We analyzed all consecutive patients at our institution during the years 1999-2010 who were admitted for...

CELL BIOLOGY AND SIGNALING

Ikaros, a DNA-binding protein also known as Ikaros family zinc finger protein 1 (IKZF1), was initially shown to function critically in hematopoietic differentiation. Deletion or mutation of Ikaros has been associated with lymphoblastic, as well as acute and chronic myelogenous leukemias demonstrating that Ikaros can act as a tumor suppressor. Ikaros is predominantly expressed in...

SURGICAL THERAPIES

INTRODUCTION: The role of aggressive surgical resection for glioblastoma multiforme (GBM) is controversial, with conflicting evidence published on the effect of extent of resection on outcome. We analyzed our patient population to determine if there was a correlation between greater extent of resection and overall survival or progression-free survival (PFS) in our neurosurgical...

Cell Biology and Signaling

Neuroblastoma, a cancer of the sympathetic nervous system, is the most common extracranial solid tumor in children. MYCN amplification and increased BDNF/TrkB signaling are features of high-grade tumors, yet only ∼25% of malignant tumors display those features. Thus, the identification of additional biomarkers and therapeutic targets is essential. Since aminoacylase 1 (ACY1), an...