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Search: authors:"Hee-Won Jung"

7 papers found.
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A practical scoring system to determine whether to proceed with surgical resection in recurrent glioblastoma

Background To determine the benefit of surgical management in recurrent glioblastoma, we analyzed a series of patients with recurrent glioblastoma who had undergone surgery, and we devised a new scale to predict their survival.

Therapeutic efficacy and safety of TRAIL-producing human adipose tissue–derived mesenchymal stem cells against experimental brainstem glioma

Mesenchymal stem cells (MSCs) have an extensive migratory capacity for gliomas, which is comparable to that of neural stem cells. Among the various types of MSCs, human adipose tissue-derived MSCs (hAT-MSC) emerge as one of the most attractive vehicles for gene therapy because of their high throughput, lack of ethical concerns, and availability and ease of isolation. We evaluated...

Usefulness of MS-MLPA for detection of MGMT promoter methylation in the evaluation of pseudoprogression in glioblastoma patients

Pseudoprogression is a major diagnostic dilemma in current treatment protocols for malignant gliomas that involve concurrent chemoradiotherapy. We hypothesized that methylation-specific multiplex ligation probe amplification (MS-MLPA), an assay that permits semiquantitative evaluation of promoter methylation, may be used to diagnose pseudoprogression based on the quantification...

NEUROSURGICAL TREATMENTS

Patients with cancer are at high risk of developing venous thromboembolism (VTE). The purpose of this study was to review VTE development in patients undergoing craniotomy for a neoplasm, and to further analyze risk based on multiple pre-, intra-, and post-operative variables. We analyzed all consecutive patients at our institution during the years 1999-2010 who were admitted for...

CELL BIOLOGY AND SIGNALING

Ikaros, a DNA-binding protein also known as Ikaros family zinc finger protein 1 (IKZF1), was initially shown to function critically in hematopoietic differentiation. Deletion or mutation of Ikaros has been associated with lymphoblastic, as well as acute and chronic myelogenous leukemias demonstrating that Ikaros can act as a tumor suppressor. Ikaros is predominantly expressed in...

SURGICAL THERAPIES

INTRODUCTION: The role of aggressive surgical resection for glioblastoma multiforme (GBM) is controversial, with conflicting evidence published on the effect of extent of resection on outcome. We analyzed our patient population to determine if there was a correlation between greater extent of resection and overall survival or progression-free survival (PFS) in our neurosurgical...

Cell Biology and Signaling

Neuroblastoma, a cancer of the sympathetic nervous system, is the most common extracranial solid tumor in children. MYCN amplification and increased BDNF/TrkB signaling are features of high-grade tumors, yet only ∼25% of malignant tumors display those features. Thus, the identification of additional biomarkers and therapeutic targets is essential. Since aminoacylase 1 (ACY1), an...