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Austrian Experience with Lixisenatide Under Real-Life Conditions: A Prospective Observational Study

. Disclosures Helmut Brath has acted as speaker or advisory board member for Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Medtronic, MSD, Mylan, Novartis, Novo Nordisk, Pfizer, Sanofi, and Servier

Andere spezifische Diabetesformen und exokrine Pankreasinsuffizienz (Update 2019)

ZusammenfassungDie unter der Kategorie „andere spezifische Diabetesformen“ zusammengefassten Störungen des Glukosestoffwechsels stellen pathophysiologisch und therapeutisch eine sehr heterogene Krankheitsgruppe dar. Umfasst werden Diabetesformen, die im Rahmen von anderen endokrinologischen Erkrankungen auftreten (z. B. Akromegalie, Cushing-Syndrom), pankreoprive Formen (z. B...

Antihyperglykämische Therapie bei Diabetes mellitus Typ 2 (Update 2019)

Heidemarie hat Vortragshonorare und Honorare für Beratungstätigkeit von folgenden Firmen erhalten: Eli Lilly, Astra Zeneca, Boehringer Ingelheim, Amgen, Sanofi, Novo Nordisk, Servier, MSD. Helmut Brath erhielt

Relationship Between Duration of Type 2 Diabetes and Effectiveness of DPP-4 Inhibitor Versus Sulfonylurea as Add-on Therapy: A Post Hoc Analysis

authors contributed to the conception, design, and interpretation of the analysis. Giovanni Bader contributed towards statistical analyses. Helmut Brath drafted the first draft of the manuscript; Pa¨ivi M ... the data and approved the final manuscript for submission. Disclosures. Helmut Brath has received honoraria for lectures and advisory board/ speaker’s bureau fees from all major diabetes companies

Association of Genomic Instability with HbA1c levels and Medication in Diabetic Patients

Diabetes Mellitus type 2 (DM2) is associated with increased cancer risk. Instability of the genetic material plays a key role in the aetiology of human cancer. This study aimed to analyse genomic instability with the micronucleus cytome assay in exfoliated buccal cells depending on glycated haemoglobin (HbA1c) levels and medication in 146 female DM2 patients. The occurrence of...

Prevalence and Correlates of Smoking and Readiness to Quit Smoking in People Living with HIV in Austria and Germany

We aimed to investigate the prevalence and correlates of smoking in people living with HIV (PLWHIV) in Germany and Austria and their readiness to quit. A total of 447 consecutive patients with confirmed positive HIV status who were treated in different outpatient HIV centres in Austria and Germany were included. Nicotine dependence and stages of change were assessed by...

Oxidative Stress, DNA Damage and DNA Repair in Female Patients with Diabetes Mellitus Type 2

Background Diabetes mellitus type 2 (T2DM) is associated with oxidative stress which in turn can lead to DNA damage. The aim of the present study was to analyze oxidative stress, DNA damage and DNA repair in regard to hyperglycemic state and diabetes duration. Methods Female T2DM patients (n = 146) were enrolled in the MIKRODIAB study and allocated in two groups regarding their...

Nuclear anomalies in exfoliated buccal cells in healthy and diabetic individuals and the impact of a dietary intervention

This study aimed to compare the frequencies of nuclear anomalies in buccal cells between diabetic and non-diabetic individuals and to assess the impact of a ‘healthy diet’—a cornerstone in the treatment of diabetes. Seventy-six diabetic and 21 non-diabetic individuals participated in this parallel, randomised, intervention trial. All participants received information about the...

Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects

Background Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain the genomic integrity and MMR-deficient cells show an increased mutation rate. One important gene in the MMR complex is the MutL homolog 1 (MLH1) gene. Since a...

Genome damage in peripheral blood lymphocytes of diabetic and non-diabetic individuals after intervention with vegetables and plant oil

Recent studies suggest increased cancer risk in patients with type 2 diabetes mellitus (T2DM) compared with healthy individuals. The present study aims to assess whether T2DM is associated with increased genome instability and whether a healthy diet with natural foods can improve genome stability in peripheral blood lymphocytes (PBLs). Seventy-six diabetic and 21 non-diabetic...