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Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

Aims/hypothesisThe aim of this study was to elucidate the impact of 3′-phosphoinositide-dependent protein kinase-1 (PDPK1) in vascular endothelial cells on the maintenance of pancreatic beta cell mass and function.MethodsMale vascular endothelial cell-specific Pdpk1-knockout mice (Tie2+/−/Pdpk1flox/flox mice) and their wild-type littermates (Tie2−/−/Pdpk1flox/flox mice; control...

Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism

Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion from pancreatic beta cells and suppresses glucagon secretion from alpha cells. It remains controversial, however, whether GLP-1 receptor (GLP-1R) is expressed in mature alpha cells. In this study, unlike previous studies using non-diabetic animals, we demonstrated using diabetic model rats and confocal laser scanning...

There is a Close Association Between the Recovery of Liver Injury and Glycemic Control after SGLT2 Inhibitor Treatment in Japanese Subjects with Type 2 Diabetes: A Retrospective Clinical Study

contributions. Tomoe Kinoshita, Masashi Shimoda, Hideaki Kaneto researched data and wrote the manuscript. Junpei Sanada, Yoshiro Fushimi, Yurie Hirata, Shintaro Irie, Atsushi Obata, Tomohiko Kimura, Hidenori ... Hirukawa, Kenji Kohara, Fuminori Tatsumi, Shinji Kamei, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku participated in discussion. Disclosures. Hideaki Kaneto has received honoraria for lectures and received

Effect of Tofogliflozin on Body Composition and Glycemic Control in Japanese Subjects with Type 2 Diabetes Mellitus

and Metabolism, Kawasaki Medical School, Kurashiki, Japan 2Iwamoto Internal Medicine Clinic, Kagawa, Japan Correspondence should be addressed to Hideaki Kaneto; Received 7 ... Boehringer Ingelheim, Chugai Pharmaceutical, Daiichi Sankyo, and Sanofi. Hideaki Kaneto and Kohei Kaku received honoraria for lectures from Chugai Pharmaceutical, Kowa, and Sanofi who manufacture tofogliflozin

Inadequate Triglyceride Management Worsens the Durability of Dipeptidyl Peptidase-4 Inhibitor in Subjects with Type 2 Diabetes Mellitus

. Acknowledgments Hideaki Kaneto has received honoraria for lectures and received scholarship grants from Sanofi, Novo Nordisk, Lilly, Nippon Boehringer Ingelheim Co., MSD, Mochida Pharmaceutical Co., Kyowa Hakko

Relationship between frequency of hypoglycemic episodes and changes in carotid atherosclerosis in insulin-treated patients with type 2 diabetes mellitus

Toshihiko Shiraiwa HidenoriYoshii Nobuichi Kuribayashi Takeshi Osonoi Hideaki Kaneto Keisuke Kosugi Yutaka Umayahara Masahiko Gosho Iichiro Shimomura Hirotaka Watada OPEN The effect of hypoglycemia on the

A case of hypothalamic hypopituitarism accompanied by recurrent severe hypoglycemia

Introduction Hypothalamic hypopituitarism is relatively rare cause of secondary adrenal deficiency which is often accompanied by severe hypoglycemia. Hydrocortisone replacement therapy is essential for this condition, but gastrointestinal symptom such as nausea and vomiting is not well-recognized adverse effect of hydrocortisone. Case description A 64-year-old-woman was referred...

Ice Cube Tray–Shaped Insulin Lipoatrophy Throughout the Abdomen in a Subject With Type 2 Diabetes

School , Kurashiki , Japan 1 Kenji Kohara , Hideaki Kaneto, Shinji Kamei, Masashi Shimoda, Sumiko Hamamoto, Kazuhito Tawaramoto, Michihiro Matsuki, Tomoatsu Mune, and Kohei Kaku - S N O I T A V R E S B O

Dramatic mitigation of bone pain after phosphorus replacement therapy in a subject with FGF23-related hypophosphatemic osteomalacia

Introduction Fibroblast growth factor 23 (FGF23) is secreted from bone and suppresses the absorption of phosphorus in renal proximal tubule and in intestinal tract. Therefore, the increase of serum FGF23 levels leads to hypophosphatemic situations. Tumor-induced osteomalacia is often induced by various tumors, but it is often difficult to identify the localization of tumor...

Strawberry milk-like blood in a subject with diabetic lipemia: dramatic change to transparent color after insulin therapy

Introduction It is known that chylomicronemia is caused by several pathologies and is classified as primary and secondary chylomicronemia. Since hypertriglycemia is associated with an increased risk of cardiovascular disease and severe pancreatitis, it is very important to make a proper diagnosis of the cause of hypertriglycemia. Case description We herein present the case of a...

Risk categorization for calculating net reclassification improvement

Mitsuyoshi Takahara Naoto Katakami Hideaki Kaneto Iichiro Shimomura - We read with great interest a recent report by Muhlenbruch and colleagues [1], clearly demonstrating the dependency of the net

Azelnidipine, but not amlodipine, reduces urinary albumin excretion and carotid atherosclerosis in subjects with type 2 diabetes: blood pressure control with olmesartan and azelnidipine in Type 2 diabetes (BOAT2 study)

To evaluate the efficacy of azelnidipine and amlodipine on diabetic nephropathy and atherosclerosis, we designed a prospective and randomized controlled clinical study in type 2 diabetic patients with stable glycemic control with fixed dose of anti-diabetic medication. Although there was no difference in blood pressure between both groups, urinary albumin excretion and maximum...

Rationale, Design, and Baseline Characteristics of the Utopia Trial for Preventing Diabetic Atherosclerosis Using an SGLT2 Inhibitor: A Prospective, Randomized, Open-Label, Parallel-Group Comparative Study

Nordisk Pharma Ltd., Eli Lilly Japan K.K., and Kissei Pharmaceutical Co., Ltd. as well as research funding from Kowa Pharmaceutical Co. Ltd. and Mitsubishi Tanabe Pharma Corporation. Hideaki Kaneto has

Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice

Aims/hypothesis Lineage conversion of non-beta cells into insulin-producing cells has been proposed as a therapy for the cure of diabetes. Glucagon-like peptide-1 (GLP-1) and its derivatives can induce beta cell neogenesis in vitro and beta cell mass expansion in vivo, but GLP-1 signalling has not been shown to regulate cell fate decisions in vivo. We therefore tested the impact...