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Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma

We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese and other East Asian populations. We identified 65 SNPs with P...

Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens–Johnson syndrome with severe ocular complications

A genome-wide association study (GWAS) for cold medicine-related Stevens–Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional...

New Susceptibility and Resistance HLA-DP Alleles to HBV-Related Diseases Identified by a Trans-Ethnic Association Study in Asia

-ippan-011 and H24-kanenippan-004 to Masashi Mizokami, H23-kanen-005 to Katsushi Tokunaga, H25-kanen-wakate-013 to Nao Nishida, and H25-kanen-wakate-012 to Hiromi Sawai. This work was also supported by The ... Young Scientists (B) to Hiromi Sawai, is also acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Hepatitis B virus

Soluble MICA and a MICA Variation as Possible Prognostic Biomarkers for HBV-Induced Hepatocellular Carcinoma

MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of...

HLA-A*0206 with TLR3 Polymorphisms Exerts More than Additive Effects in Stevens-Johnson Syndrome with Severe Ocular Surface Complications

Sawai Gen Tamiya Tsutomu Inatomi Shigeru Kinoshita Yoshihiko Hoshino, National Institute of Infectious Diseases, Japan Background: Stevens-Johnson syndrome (SJS) is an acute inflammatory vesiculobullous

Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean

Hepatitis B virus (HBV) infection can lead to serious liver diseases, including liver cirrhosis (LC) and hepatocellular carcinoma (HCC); however, about 85–90% of infected individuals become inactive carriers with sustained biochemical remission and very low risk of LC or HCC. To identify host genetic factors contributing to HBV clearance, we conducted genome-wide association...

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

Hiromi Sawai 0 Nao Nishida 0 Hamdi Mbarek Koichi Matsuda Yoriko Mawatari Megumi Yamaoka 0 Shuhei Hige Jong-Hon Kang Koichi Abe Satoshi Mochida Masaaki Watanabe Masayuki Kurosaki Yasuhiro Asahina

Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites

Hiromi Sawai 0 Hiroto Otani 0 Nobuko Arisue Nirianne Palacpac Leonardo de Oliveira Martins Sisira Pathirana Shiroma Handunnetti Satoru Kawai Hirohisa Kishino Toshihiro Horii Kazuyuki Tanabe 0 0