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38 papers found.
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Corneal lymphangiogenesis ameliorates corneal inflammation and edema in late stage of bacterial keratitis

Lymphatic vessels play a crucial role in systemic immune response and regulation of tissue fluid homeostasis. Corneal lymphangiogenesis in bacterial keratitis has not been studied. In this study, we investigated the mechanism and the role of corneal lymphangiogenesis in a murine bacterial keratitis model using Pseudomonas aeruginosa. We first demonstrated that corneal...

Dynamics of soluble vascular endothelial growth factor receptors and their ligands in aqueous humour during ranibizumab for age-related macular degeneration

Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF receptor intraocular dynamics after IRI are unclear. Therefore, we evaluated changes in the aqueous humor levels of soluble vascular endothelial growth factor receptor...

Corneal deposits associated with topical tosufloxacin following penetrating keratoplasty: a case report

Corneal deposits associated with topical tosufloxacin following penetrating keratoplasty: a case report Haruki Katahira, Shigeto Kumakura, Takaaki Hattori, Hiroshi Goto Department of Ophthalmology

Possible Relation between Lack of Posterior Vitreous Detachment and Severe Endogenous Endophthalmitis

Purpose. Endogenous endophthalmitis (EE) is a rare ocular disease caused by bacterial or fungal infection of intraocular spaces by hematogenous spread of pathogens from distant infectious loci in the body. We investigated the clinical characteristics and management of eyes with EE in ten consecutive patients. Methods. Ten patients (10 eyes) with EE treated at Tokyo Medical...

Acute aortic occlusion in a patient with chronic paralysis due to spinal cord injury: a case report

Takehiro Chiyoda 0 Hiroshi Goto 0 Yukiyoshi Masaki 0 0 Department of Surgery, Ome Municipal General Hospital , 4-16-5, Higashi Ome, Ome-shi, Tokyo 198-0042 , Japan Patients with spinal cord injury

Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging

in:Nature Research journals • PubMed • Google Scholar Search for Hiroshi Goto in:Nature Research journals • PubMed • Google Scholar Contributions Writing the manuscript: M.M. Development of PS-OCT: S.M

Aqueous immune mediators in malignant uveal melanomas in comparison to benign pigmented intraocular tumors

BackgroundTo examine the usefulness of measuring immune mediators in aqueous humor samples for differentiating malignant uveal melanoma from benign pigmented intraocular tumors.MethodsThirteen eyes of 13 patients with uveal melanoma were studied, and 13 eyes of 13 patients with benign pigmented intraocular tumors served as controls. Undiluted samples of aqueous humor were...

Use of the sit-to-stand task to evaluate motor function of older adults using telemetry

Background Physical exercises are widely used in community programs, but not all older adults are willing to participate. Information and communication technology may solve this problem by allowing older people to participate in fitness programs at home. Use of remote instruction will facilitate physical exercise classes without requiring that participants gather at one place...

Macular hole formation following intravitreal injection of ranibizumab for branch retinal vein occlusion: a case report

BackgroundMacular hole formation after anti-vascular endothelial growth factor therapy is a rare complication. We report macular hole formation after intravitreal ranibizumab injection for branch retinal vein occlusion.Case presentationA 63-year-old Asian male was treated with intravitreal ranibizumab injection for chronic macular edema with branch retinal vein occlusion in his...

Comprehensive polymerase chain reaction assay for detection of pathogenic DNA in lymphoproliferative disorders of the ocular adnexa

• Google ScholarSearch for Hiroshi Goto in:Nature Research journals • PubMed • Google ScholarSearch for Sunao Sugita in:Nature Research journals • PubMed • Google Scholar Contributions Study design: Y.U

A case of herpes zoster uveitis with severe hyphema

Background Uveitis sometimes causes hyphema, but severe hyphema as a complication following herpes zoster uveitis has rarely been reported. We report a rare case of zoster sine herpete with unusually severe hyphema. Case presentation A 41-year-old Japanese female developed hyphema filling almost one-half of the depth of the anterior chamber after a two-week history of unilateral...

A case of presumed choroidal metastasis from carcinoid tumor treated by photodynamic therapy with verteporfin

A case of presumed choroidal metastasis from carcinoid tumor treated by photodynamic therapy with verteporfin Setsuko Kawakami, Yoshihiro Wakabayashi, Hiroshi Goto Department of Ophthalmology, Tokyo

Retrospective study of threshold time for the conventional treatment of branch retinal artery occlusion

1 Daisuke Muramatsu 2 Yoshihiro Wakabayashi hiroshi goto Purpose: To investigate the medical backgrounds of patients and the treatment periods from the onset of branch retinal artery occlusion to

Noninvasive vascular imaging of ruptured retinal arterial macroaneurysms by Doppler optical coherence tomography

Background To describe Doppler optical coherence tomography (OCT) imaging of ruptured retinal arterial macroaneurysms (RAMs). Methods Four eyes of four patients with ruptured RAMs were prospectively studied. Vascular imaging was obtained using swept-source Doppler OCT, and compared with indocyanine green angiography images. Results En face projection of Doppler OCT images clearly...

Angiolymphoid hyperplasia with eosinophilia occurring in bilateral eyelids

Background Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign lesion, primarily occurring in the head and neck. ALHE arising from the ocular adnexa is rare, and the bilateral presentation is especially rare in the eyelids. Case presentation A 64-year-old Japanese man presented with tearing. Multiple nodules, approximately 5 mm in size, were observed in...

Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients

Incidence of deepening of upper eyelid sulcus after topical use of tafluprost ophthalmic solution in Japanese patients Katsuhiko Maruyama,1 Asako Tsuchisaka,1 Jumpei Sakamoto,1 Shiroaki Shirato,2 Hiroshi Goto11Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan; 2Yotsuya Shirato Eye Clinic, Tokyo, JapanPurpose: To investigate the incidence of deepening of upper...

Two-year follow-up of ranibizumab combined with photodynamic therapy for polypoidal choroidal vasculopathy

Two-year follow-up of ranibizumab combined with photodynamic therapy for polypoidal choroidal vasculopathy Rei Nemoto,1,2 Masahiro Miura,1,2 Takuya Iwasaki,1,2 Hiroshi Goto21Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Ami, Ibaraki, Japan; 2Department of Ophthalmology, Tokyo Medical University, Nishi-Shinjuku, Tokyo, JapanPurpose: We evaluated...

A case of sebaceous adenoma of the eyelid showing excessively rapid growth

A case of sebaceous adenoma of the eyelid showing excessively rapid growth Kei Takayama,1 Yoshihiko Usui,2 Masataka Ito,3 Hiroshi Goto,2 Masaru Takeuchi1 1Department of Ophthalmology, National

A case of orbital sebaceous gland carcinoma developing in an anophthalmic socket 65 years after enucleation

A case of orbital sebaceous gland carcinoma developing in an anophthalmic socket 65 years after enucleation Motoko Shibata,1,* Yoshihiko Usui,1,* Shunichiro Ueda,1 Hajime Matsumura,2 Toshitaka Nagao,3 Hiroshi Goto1 1Department of Ophthalmology, 2Department of Plastic and Reconstructive Surgery, 3Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan *These...