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12 papers found.
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Spatial and temporal profile of cisplatin delivery by ultrasound-assisted intravesical chemotherapy in a bladder cancer model

: Noboru Sasaki. Funding acquisition: Noboru Sasaki, Mitsuyoshi Takiguchi. Methodology: Noboru Sasaki, Nobuki Kudo. Resources: Nobuki Kudo. Supervision: Hiroshi Ohta, Mitsuyoshi Takiguchi. Validation ... Morishita, Hiroshi Ohta. 9 / 11 10 / 11 1. Antoni S , Ferlay J , Soerjomataram I , Znaor A , Jemal A , Bray F. Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends . Eur Urol . 2017

Urinary exosome-derived microRNAs reflecting the changes of renal function and histopathology in dogs

MicroRNAs act as post-transcriptional regulators, and urinary exosome (UExo)-derived microRNAs may be used as biomarkers. Herein, we screened for UExo-derived microRNAs reflecting kidney disease (KD) status in dogs. Examined dogs were divided into healthy kidney control (HC) and KD groups according to renal dysfunction. We confirmed the appearance of UExo having irregular globe...

Association between asymptomatic hyperuricemia and new-onset chronic kidney disease in Japanese male workers: a long-term retrospective cohort study

Hiroshi Ohta 0 Hiroyuki Terawaki Yoshiharu Aizawa 0 0 Department of Preventive Medicine and Public Health, Kitasato University School of Medicine , Sagamihara , Japan Background: Hyperuricemia is prevalent

Functional full-term placentas formed from parthenogenetic embryos using serial nuclear transfer

Takafusa Hikichi 1 Hiroshi Ohta 0 Sayaka Wakayama Teruhiko Wakayama 0 Present address: Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University , Yoshida-Konoe-cho, Sakyo

Age- and substrain-dependent sperm abnormalities in BALB/c mice and functional assessment of abnormal sperm by ICSI

Hiroshi Ohta 0 Yuko Sakaide 0 Teruhiko 0 0 Laboratory for Genomic Reprogramming, Center for Developmental Biology, RIKEN , 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047 , Japan background

Assessment of Border Control Measures and Community Containment Measures Used in Japan during the Early Stages of Pandemic (H1N1) 2009

Background In the early stages of Pandemic (H1N1) 2009, border control measures were taken by quarantine stations to block the entry of infected individuals into Japan and community containment measures were implemented to prevent the spreading. The objectives of this study were to describe these measures and the characteristics of infected individuals, and to assess the measures...

Abnormality of risk factors for atherosclerotic disease among young Japanese aged 19–39 years old: an evaluation of health checkup data

Objectives Japanese public health policies on the prevention of atherosclerotic diseases have focused on controlling obesity. The aim of this study was to assess the prevalence of abnormality in risk factors for atherosclerotic disease among young Japanese classified according to body mass index (BMI). Methods Data were obtained from 359 men (mean age 32 ± 5 years) and 1,108...

Generation of progeny via ICSI following enrichment of elongated spermatids from mouse testis by flow-cytometric cell sorting

Hiroshi Ohta 0 Yuko Sakaide 0 Teruhiko Wakayama 0 0 Laboratory for Genomic Reprogramming, Center for Developmental Biology, RIKEN , Chuo-ku, Kobe 650-0047 , Japan BACKGROUND: Although ICSI is a

Maternal and paternal family history of type 2 diabetes differently influence lipid parameters in young nondiabetic Japanese women

ObjectivesWe assessed the association of family history of type 2 diabetes (T2D) with parameters used for health checkups in young Japanese women.MethodsThe subjects were 497 nondiabetic women aged 19–39 years. Among them, the mothers of 34 subjects and fathers of 50 had T2D (MD group and PD group, respectively). The subjects were assessed for levels of total cholesterol (TC...

Maintenance of influenza virus infectivity on the surfaces of personal protective equipment and clothing used in healthcare settings

ObjectivesThe maintenance of infectivity of influenza viruses on the surfaces of personal protective equipment and clothing is an important factor in terms of controlling viral cross-infection in the environment and preventing contact infection. The aim of this study was to determine if laboratory-grown influenza A (H1N1) virus maintained infectivity on the surfaces of personal...

Methylation of CpG dinucleotides in the open reading frame of a testicular germ cell‐specific intronless gene, Tact1/Actl7b, represses its expression in somatic cells

Methylation of CpG islands spanning promoter regions is associated with control of gene expression. However, it is considered that methylation of exonic CpG islands without promoter is not related to gene expression, because such exonic CpG islands are usually distant from the promoter. Whether methylation of exonic CpG islands near the promoter, as in the case of a CpG‐rich...

cAMP-responsive element in TATA-less core promoter is essential for haploid-specific gene expression in mouse testis

Promoters, including neither TATA box nor initiator, have been frequently found in testicular germ cell-specific genes in mice. These investigations imply that unique forms of the polymerase II transcription initiation machinery play a role in selective activation of germ cell-specific gene expression programs during spermatogenesis. However, there is little information about...