Advanced search    

Search: authors:"Hiroshi Shibuya"

11 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Analysis of the Cost-effectiveness of Photodynamic Therapy in Early Stage Lung Cancer

Methods A cost-effectiveness analysis was carried out for photodynamic therapy (PDT) performed in early stage lung cancer cases, which by definition have no lymph node metastasis. The alternative treatment method was lobectomy, which conventionally would have been the first choice of treatment. Costs (C) and effectiveness (E) both of the PDT group and operation group were...

Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway

, Culture, Sports , Science and Technology of Japan , 26460386, to Dr. Atsushi Sato; and Nanken-Kyoten, TMDU, 17M03, to Prof. Hiroshi Shibuya 2 Editor: Renping Zhou, Rutgers University , UNITED STATES The ... : Hiroshi Shibuya. Data curation: Atsushi Sato, Hiroshi Shibuya. Formal analysis: Atsushi Sato. Supervision: Hiroshi Shibuya. Validation: Atsushi Sato. Visualization: Atsushi Sato. Writing ± original

WNK Signaling Is Involved in Neural Development via Lhx8/Awh Expression

WNK kinase family is conserved among many species and regulates SPAK/OSR1 and ion co-transporters. Some mutations in human WNK1 or WNK4 are associated with Pseudohypoaldosteronism type II, a form of hypertension. WNK is also involved in developmental and cellular processes, but the molecular mechanisms underlying its regulation in these processes remain unknown. Here, we identify...

Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response Assay

The chemosensitivity of anaplastic thyroid cancer (ATC) to some cytotoxic agents was investigated by the histoculture drug response assay (HDRA). Thirty specimens from 22 patients with ATC were obtained from surgically resected subjects. The drugs tested were paclitaxel (PTX), docetaxel (DOC), adriamycin (ADM), nedaplatin (254-S), cisplatin (CDDP), carboplatin (CBDCA), etoposide...

Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response Assay

The chemosensitivity of anaplastic thyroid cancer (ATC) to some cytotoxic agents was investigated by the histoculture drug response assay (HDRA). Thirty specimens from 22 patients with ATC were obtained from surgically resected subjects. The drugs tested were paclitaxel (PTX), docetaxel (DOC), adriamycin (ADM), nedaplatin (254-S), cisplatin (CDDP), carboplatin (CBDCA), etoposide...

IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling

Dishevelled (DVL) is a central factor in the Wnt signaling pathway, which is highly conserved among various organisms. DVL plays important roles in transcriptional activation in the nucleus, but the molecular mechanisms underlying their nuclear localization remain unclear. In the present study, we identified IQGAP1 as a regulator of DVL function. In Xenopus embryos, depletion of...

Study of hadron interactions in a lead–emulsion target

The topological and kinematical characteristics of hadron interactions have been studied using a lead–emulsion target exposed to 2, 4, and 10 GeV/$c$ hadron beams. A total length of 60 m $\pi ^-$ tracks was followed using a high-speed automated emulsion scanning system. A total of 318 hadron interaction vertices and their secondary charged particle tracks were reconstructed. The...

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor

ScholarSearch for Tohru Natsume in:Nature Research journals • PubMed • Google ScholarSearch for Masayuki Komada in:Nature Research journals • PubMed • Google ScholarSearch for Hiroshi Shibuya in:Nature Research

Retraction: DNA demethylation in hormone-induced transcriptional derepression

Matsumoto Sally Fujiyama Yuko Shirode Ikuko Yamaoka Hirochika Kitagawa Ken-Ichi Takeyama Hiroshi Shibuya Fumiaki Ohtake Shigeaki Kato - In this Letter, we claimed that hormone-regulated transcriptional

A histone lysine methyltransferase activated by non-canonical Wnt signalling supresses PPAR-γ transactivation

Igarashi Min-Young Youn Ken-ichi Takeyama Takashi Nakamura Yoshihiro Mezaki Shinichiro Takezawa Yoshiko Yogiashi Hirochika Kitagawa Gen Yamada Shinji Takada Yasuhiro Minami Hiroshi Shibuya Kunihiro Matsumoto

Pediatric differentiated thyroid carcinoma in stage I: risk factor analysis for disease free survival

Background To examine the outcomes and risk factors in pediatric differentiated thyroid carcinoma (DTC) patients who were defined as TNM stage I because some patients develop disease recurrence but treatment strategy for such stage I pediatric patients is still controversial. Methods We reviewed 57 consecutive TNM stage I patients (15 years or less) with DTC (46 papillary and 11...