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Development of a novel immunoproteasome digestion assay for synthetic long peptide vaccine design

development of therapeutic strategies for tumors and infectious disease. Supporting information S1 Checklist. NC3Rs ARRIVE guidelines checklist. (PDF) Author Contributions Conceptualization: Hiroshi Wada ... . Project administration: Eiji Sasaki. Formal analysis: Hiroshi Wada, Atsushi Shimizu, Toshihiro Osada, Yuki Tanaka, Satoshi Fukaya. 12 / 15 (26):2443±54. Epub 2012/06/05. https://doi.org/10.1056

Estimating optimal sparseness of developmental gene networks using a semi-quantitative model

To estimate gene regulatory networks, it is important that we know the number of connections, or sparseness of the networks. It can be expected that the robustness to perturbations is one of the factors determining the sparseness. We reconstruct a semi-quantitative model of gene networks from gene expression data in embryonic development and detect the optimal sparseness against...

Magnetic compression anastomosis for the complete dehiscence of hepaticojejunostomy in a patient after living-donor liver transplantation

BackgroundMagnetic compression anastomosis (MCA) is a minimally invasive method of anastomosis that does not involve a surgical procedure in patients with stricture, obstruction, or dehiscence of anastomosis after surgery. We experienced a case of complete dehiscence of bilioenteric anastomosis that was successfully treated by MCA.Case presentationA 55-year-old woman received ABO...

Turgor-responsive starch phosphorylation in Oryza sativa stems: A primary event of starch degradation associated with grain-filling ability

24228004. RE-B is a research member of National Council of Scientific and Technological Research (CONICET), Argentina. Conceptualization: Hiroshi Wada, Chisato Masumoto-Kubo, Satoshi Morita. Formal analysis ... : Hiroshi Wada, Chisato Masumoto-Kubo. Funding acquisition: Hiroshi Wada, Hiroshi Nonami, Satoshi Morita. Investigation: Hiroshi Wada, Chisato Masumoto-Kubo, Koichi Tsutsumi, Fukuyo Tanaka, Methodology

Feasibility and Efficacy of Autologous Bone Marrow Aspirate Transplantation Combined with Human Parathyroid Hormone 1-34 Administration to Treat Osteonecrosis in a Rabbit Model

 Tomokazu Yoshioka,2 Hisashi Sugaya,2 Katsuya Aoto,1 Hiroshi Wada,1 Kenta Uemura,1 Kenta Tanaka,1 Hiroshi Akaogi,1 Masashi Yamazaki,1 and Hajime Mishima1 1Department of Orthopedics Surgery, Faculty of

A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express α-gal epitopes

, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Koichi Kawamoto, Kunihito Goto, Kiyomi Taniyama. Methodology: Masahiro Tanemura. Project administration: Masahiro Tanemura. Supervision

Agenesis of the left hepatic lobe undergoing laparoscopic hepatectomy for hepatocellular carcinoma: a case report

Hidetoshi Eguchi Yoshihumi Iwagami Daisaku Yamada Tadafumi Asaoka Takehiro Noda Hiroshi Wada Koichi Kawamoto Yuichiro Doki Masaki Mori Background: Agenesis of the left hepatic lobe is a rare anomaly. It is

Three-Dimensional Analysis of the Contact Pattern between the Cortical Bone and Femoral Prosthesis after Cementless Total Hip Arthroplasty

 Korovessis Copyright © 2016 Hiroshi Wada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in

Three-Dimensional Analysis of the Contact Pattern between the Cortical Bone and Femoral Prosthesis after Cementless Total Hip Arthroplasty

 Korovessis Copyright © 2016 Hiroshi Wada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in

Three-Dimensional Analysis of the Contact Pattern between the Cortical Bone and Femoral Prosthesis after Cementless Total Hip Arthroplasty

 Korovessis Copyright © 2016 Hiroshi Wada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in

Rapid Switch from Intra-Aortic Balloon Pumping to Percutaneous Cardiopulmonary Support Using Perclose ProGlide

We present a case of a patient who needed rapid switch from intra-aortic balloon pumping (IABP) to percutaneous cardiopulmonary support (PCPS)/venoarterial extracorporeal membrane oxygenation. It is difficult to switch from IABP to PCPS, because 0.035-inch guidewires cannot pass the IABP guidewire lumen (0.025-inch compatible), and the IABP sheath needs to be removed together...

Rapid Switch from Intra-Aortic Balloon Pumping to Percutaneous Cardiopulmonary Support Using Perclose ProGlide

We present a case of a patient who needed rapid switch from intra-aortic balloon pumping (IABP) to percutaneous cardiopulmonary support (PCPS)/venoarterial extracorporeal membrane oxygenation. It is difficult to switch from IABP to PCPS, because 0.035-inch guidewires cannot pass the IABP guidewire lumen (0.025-inch compatible), and the IABP sheath needs to be removed together...

Hemichordate neurulation and the origin of the neural tube

, Japan AffiliationsGraduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, JapanNorio Miyamoto & Hiroshi Wada AuthorsSearch for Norio Miyamoto in:Nature Research ... journals • PubMed • Google ScholarSearch for Hiroshi Wada in:Nature Research journals • PubMed • Google Scholar Contributions N.M. and H.W. contributed to the design of experiments. N.M. performed sample

Two cases of resectable pancreatic cancer diagnosed by open surgical biopsy after endoscopic ultrasound fine-needle aspiration failed to yield diagnosis: case reports

BackgroundTumor biopsy for histological diagnosis is required preoperatively and before initiating chemotherapy or radiation therapy for patients with pancreatic cancer (Cancer of the Pancreas: Clinical Practice Guidelines, European Society for Medical Oncology). Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is widely applied to obtain tissue samples for histological...

MicroRNA-155 Controls Exosome Synthesis and Promotes Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Noda, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Yutaka Takeda, Masahiro Tanemura, Masaki Mori & Yuichiro DokiDepartment of Surgery, Kansai Rosai Hospital, Inabasou 3-1-69, Amagasaki, Hyogo, 660-8511 ... ScholarSearch for Tadafumi Asaoka in:Nature Research journals • PubMed • Google ScholarSearch for Takehiro Noda in:Nature Research journals • PubMed • Google ScholarSearch for Hiroshi Wada in:Nature Research

Atypical glomus tumor arising in the liver: a case report

Wada 2 Eiichi Morii 0 0 Department of Pathology, Osaka University Graduate School of Medicine , 2-2 Yamada-oka, Suita, Osaka 565-0871 , Japan 1 Department of Digestive Surgery and Surgical Oncology

Characterization of major ripening events during softening in grape: turgor, sugar accumulation, abscisic acid metabolism, colour development, and their relationship with growth

Along with sugar accumulation and colour development, softening is an important physiological change during the onset of ripening in fruits. In this work, we investigated the relationships among major events during softening in grape (Vitis vinifera L.) by quantifying elasticity in individual berries. In addition, we delayed softening and inhibited sugar accumulation using a...

Increased Epicardial Adipose Tissue Is Associated with the Airway Dominant Phenotype of Chronic Obstructive Pulmonary Disease

Background Epicardial adipose tissue (EAT) has been shown to be a non-invasive marker that predicts the progression of cardiovascular disease (CVD). It has been reported that the EAT volume is increased in patients with chronic obstructive pulmonary disease (COPD). However, little is known about which phenotypes of COPD are associated with increased EAT. Methods One hundred and...