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Post-operative AICS status in completely resected lung cancer patients with pre-operative AICS abnormalities: predictive significance of disease recurrence

Research journals • PubMed • Google Scholar Search for Masahiko Higashiyama in:Nature Research journals • PubMed • Google Scholar Search for Hiroshi Yamamoto in:Nature Research journals • PubMed • Google

Perioperative dynamics and significance of plasma-free amino acid profiles in colorectal cancer

For early detection of cancer, we have previously developed the AminoIndex Cancer Screening (AICS) system, which quantifies 6 plasma-free amino acids (PFAAs) in blood samples. Herein, we examined the usefulness of the AICS in patients with colorectal cancer (CRC) by comparing the preoperative and postoperative PFAA profiles. Our study cohort consisted of 62 patients who had...

Effects of Using Alternative Extreme Pressure (EP) and Anti-Wear (AW) Additives with Oxy-Nitrided Samples

Oxy-nitriding is a widely used industrial process aiming to improve the tribological properties and performance of components. Previous studies have shown the effectiveness of the treatment with friction and wear performance, but very few have focussed on optimising this behaviour. The lubrication properties of several EP and AW additives were examined to investigate their...

HSP60 possesses a GTPase activity and mediates protein folding with HSP10

The mammalian molecular chaperone, HSP60, plays an essential role in protein homeostasis through mediating protein folding and assembly. The structure and ATP-dependent function of HSP60 has been well established in recent studies. After ATP, GTP is the major cellular nucleotide. In this paper, we have investigated the role of GTP in the activity of HSP60. It was found that HSP60...

Association between plasma concentrations of branched-chain amino acids and adipokines in Japanese adults without diabetes

journals • PubMed • Google Scholar Search for Taiki Yamaji in:Nature Research journals • PubMed • Google Scholar Search for Hiroshi Yamamoto in:Nature Research journals • PubMed • Google Scholar Search

Acceleration of small bowel motility after oral administration of dai-kenchu-to (TJ-100) assessed by cine magnetic resonance imaging

, Hiroshi Yamamoto. 9 / 11 Data curation: Akitoshi Inoue, Shinichi Ohta, Sachiko Kaida, Tsuyoshi Yamaguchi, Satoshi Murata, Toru Obata. Formal analysis: Akitoshi Inoue, Akira Furukawa, Shinichi Ohta, Nguyen ... Dai Hung Linh, Tulyeubai Syerikjan. Methodology: Akitoshi Inoue, Akira Furukawa, Hiroshi Yamamoto, Shinichi Ohta. Project administration: Akira Furukawa, Hiroshi Yamamoto. Supervision: Akira Furukawa

Plasma amino acid profile associated with fatty liver disease and co-occurrence of metabolic risk factors

Fatty liver disease (FLD) increases the risk of diabetes, cardiovascular disease, and steatohepatitis, which leads to fibrosis, cirrhosis, and hepatocellular carcinoma. Thus, the early detection of FLD is necessary. We aimed to find a quantitative and feasible model for discriminating the FLD, based on plasma free amino acid (PFAA) profiles. We constructed models of the...

Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution

, GermanyTarek Hilal, Hiroshi Yamamoto, Justus Loerke, Jörg Bürger & Christian M.T. SpahnMax-Planck Institut für Molekulare Genetik, Ihnestrasse 63-73, 14195 Berlin, GermanyJörg Bürger & Thorsten Mielke ... AuthorsSearch for Tarek Hilal in:Nature Research journals • PubMed • Google ScholarSearch for Hiroshi Yamamoto in:Nature Research journals • PubMed • Google ScholarSearch for Justus Loerke in:Nature Research

Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome

Scholar Search for Hideyuki Kanda in:Nature Research journals • PubMed • Google Scholar Search for Yasuyuki Fujita in:Nature Research journals • PubMed • Google Scholar Search for Hiroshi Yamamoto

Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy

Objective. Diabetic nephropathy is a life-threatening complication in patients with long-standing diabetes. Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to pyridoxamine, could prevent diabetic nephropathy in mice...

Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy

Objective. Diabetic nephropathy is a life-threatening complication in patients with long-standing diabetes. Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to pyridoxamine, could prevent diabetic nephropathy in mice...

Prognostic impact of CD44-positive cancer stem-like cells at the invasive front of gastric cancer

Background:The invasive tumour front may provide prognostic information. We examined the relationship between the presence of cancer stem cells (CSCs) at the invasive tumour front and prognosis in gastric cancer (GC).Methods:CD44 is a CSC marker; accordingly, CD44 standard (CD44s), CD44 variant-6 (CD44v6), and CD44 variant-9 (CD44v9) expression were examined in 123 resected...

Pulmonary rehabilitation for COPD improves exercise time rather than exercise tolerance: effects and mechanisms

Pulmonary rehabilitation for COPD improves exercise time rather than exercise tolerance: effects and mechanisms Keisuke Miki,1 Ryoji Maekura,1 Seigo Kitada,1 Mari Miki,1 Kenji Yoshimura,1 Hiroshi

Breakdown of lung framework and an increase in pores of Kohn as initial events of emphysema and a cause of reduction in diffusing capacity

Hashisako,1,4 Yukio Kashima,5,6 Tomoshi Tsuchiya,7 Naoya Yamasaki,7 Takeshi Nagayasu,7 Hiroshi Yamamoto,2 Junya Fukuoka1,6 1Nagasaki Educational and Diagnostic Center of Pathology (NEDCP), Department of

Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice

-8640, JapanAi Harashima, Seiichi Munesue, Hironori Kuroda, Hiroshi Yamamoto & Yasuhiko YamamotoDepartment of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical ... Research journals • PubMed • Google Scholar Search for Satoshi Suto in:Nature Research journals • PubMed • Google Scholar Search for Hiroshi Yamamoto in:Nature Research journals • PubMed • Google Scholar

Alteration in plasma free amino acid levels and its association with gout

Hiroki Amano Mikiko Kobayashi-Miura Hideyuki Kanda Yasuyuki Fujita Hiroshi Yamamoto Mai Yamamoto Shinya Kikuchi Atsuko Ikeda Naoko Kageyama Mina Nakamura Yasutaka Ishimaru 0 Hiroshi Sunagawa 0 Tsuyoshi

Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population

Background Recently, the association of plasma free amino acid (PFAA) profile and lifestyle-related diseases has been reported. However, few studies have been reported in large Asian populations, about the usefulness of PFAAs for evaluating disease risks. We examined the ability of PFAA profiles to evaluate lifestyle-related diseases in so far the largest Asian population...

Clinical Course and Changes in High-Resolution Computed Tomography Findings in Patients with Idiopathic Pulmonary Fibrosis without Honeycombing

Some patients with idiopathic pulmonary fibrosis (IPF) do not have honeycombing on high-resolution computed tomography (HRCT) at their initial evaluation. The clinical course and sequential changes in HRCT findings in these patients are not fully understood. We reviewed the cases of 43 patients with IPF without honeycombing on initial HRCT from institutions throughout Japan. All...

HMGB1-RAGE Axis Makes No Contribution to Cardiac Remodeling Induced by Pressure-Overload

High-mobility group box1 (HMGB1) exerts effects on inflammation by binding to receptor for advanced glycation end products (RAGE) or Toll-like receptor 4. Considering that inflammation is involved in pressure overload-induced cardiac hypertrophy, we herein attempted to investigate whether HMGB1 plays a role in myocardial hypertrophy in RAGE knockout mice as well as in the growth...

Personalized pulmonary rehabilitation and occupational therapy based on cardiopulmonary exercise testing for patients with advanced chronic obstructive pulmonary disease

, Keisuke Miki, Seigo Kitada, Mari Miki, Kenji Yoshimura, Hiroshi Yamamoto, Toshiko Kawabe, Masahide Mori Department of Respiratory Medicine and Rehabilitation, National Hospital Organization Toneyama