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Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy

Jinhua Li Xinli Qu Jun Yao Georgina Caruana Sharon D. Ricardo Yasuhiko Yamamoto Hiroshi Yamamoto John F. Bertram OBJECTIVE-A multicenter, controlled trial showed that early blockade of the renin

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

Hironori Kitade Kazuki Sawamoto Mayumi Nagashimada Hiroshi Inoue Yasuhiko Yamamoto Yoshimichi Sai Toshinari Takamura Hiroshi Yamamoto Ken-ichi Miyamoto Henry N. Ginsberg Naofumi Mukaida Shuichi

Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice: Involvement of Toll-Like Receptor 2

Receptor for advanced glycation end products (RAGE) has been shown to be involved in adiposity as well as atherosclerosis even in nondiabetic conditions. In this study, we examined mechanisms underlying how RAGE regulates adiposity and insulin sensitivity. RAGE overexpression in 3T3-L1 preadipocytes using adenoviral gene transfer accelerated adipocyte hypertrophy, whereas...

A Severe Diabetic Nephropathy Model With Early Development of Nodule-Like Lesions Induced by Megsin Overexpression in RAGE/iNOS Transgenic Mice

Many factors are involved in the pathogenesis of diabetic nephropathy. A single gene abnormality may be prerequisite but insufficient to the disease to manifest. It is therefore only when a second or sometimes a third damage is associated that the consequences of pathogenic phenotypes become evident. We generated the triple transgenic mice overexpressing megsin (a novel...

Receptor for Advanced Glycation End Products Is Involved in Impaired Angiogenic Response in Diabetes

Angiogenic response is impaired in diabetes. Here, we examined the involvement of receptor for advanced glycation end products (RAGE) in diabetes-related impairment of angiogenesis in vivo. Angiogenesis was determined in reconstituted basement membrane protein (matrigel) plugs containing vascular endothelial growth factor (VEGF) implanted into nondiabetic or insulin-deficient...

RAGE Control of Diabetic Nephropathy in a Mouse Model: Effects of RAGE Gene Disruption and Administration of Low–Molecular Weight Heparin

Takasawa Hiroshi Okamoto Hiroshi Yamamoto Diabetic nephropathy is a major microvascular complication in long-standing diabetic patients who eventually undergo renal dialysis or transplantation. To prevent

Amelioration of Diabetes Mellitus in Partially Depancreatized Rats by Poly(ADP-ribose) Synthetase Inhibitors: Evidence of Islet B-Cell Regeneration

publication 15 December 1983 1 YUTAKA YONEMURA , TORU TAKASHIMA, KOICHI MIWA, ITSUO MIYAZAKI, HIROSHI YAMAMOTO, AND HIROSHI OKAMOTO SUMMARY Ninety percent depancreatized rats received daily intraperitoneal